1VVC
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2AV6
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4ZER
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![BU of 4zer by Molmil](/molmil-images/mine/4zer) | Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16s ribosomal RNA, 23s ribosomal RNA, ... | Authors: | Seefeldt, A.C, Nguyen, F, Antunes, S, Perebaskine, N, Graf, M, Arenz, S, Inampudi, K.K, Douat, C, Guichard, G, Wilson, D.N, Innis, C.A. | Deposit date: | 2015-04-20 | Release date: | 2015-05-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat.Struct.Mol.Biol., 22, 2015
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2AZD
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4KR4
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4OVL
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![BU of 4ovl by Molmil](/molmil-images/mine/4ovl) | Interrogating HIV integrase for compounds that bind- a SAMPL challenge | Descriptor: | 1,2-ETHANEDIOL, 3-[(E)-(2-oxidanylidene-1H-indol-3-ylidene)methyl]benzoic acid, ACETIC ACID, ... | Authors: | Peat, T.S. | Deposit date: | 2013-11-21 | Release date: | 2014-03-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Interrogating HIV integrase for compounds that bind--a SAMPL challenge. J. Comput. Aided Mol. Des., 28, 2014
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2WD3
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![BU of 2wd3 by Molmil](/molmil-images/mine/2wd3) | Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template | Descriptor: | 3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)BIPHENYL-4-YL SULFAMATE, CARBONIC ANHYDRASE 2, ZINC ION | Authors: | Woo, L.W.L, Jackson, T, Putey, A, Cozier, G, Leonard, P, Acharya, K.R, Chander, S.K, Purohit, A, Reed, M.J, Potter, B.V.L. | Deposit date: | 2009-03-19 | Release date: | 2010-02-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors Based on a Biphenyl Template. J.Med.Chem., 53, 2010
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5UAL
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![BU of 5ual by Molmil](/molmil-images/mine/5ual) | Escherichia coli RNA polymerase and Rifampin complex, RpoB S531L mutant | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | Deposit date: | 2016-12-19 | Release date: | 2017-01-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.887 Å) | Cite: | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
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5UAC
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![BU of 5uac by Molmil](/molmil-images/mine/5uac) | Escherichia coli RNA polymerase and Rifampin complex, wild-type | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | Deposit date: | 2016-12-19 | Release date: | 2017-01-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
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5UAH
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![BU of 5uah by Molmil](/molmil-images/mine/5uah) | Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | Deposit date: | 2016-12-19 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis. Mol. Microbiol., 103, 2017
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5FLG
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![BU of 5flg by Molmil](/molmil-images/mine/5flg) | Crystal structure of the 6-carboxyhexanoate-CoA ligase (BioW)from Bacillus subtilis in complex with AMPPNP | Descriptor: | 6-CARBOXYHEXANOATE--COA LIGASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Moynie, L, Wang, M, Campopiano, D.J, Naismith, J.H. | Deposit date: | 2015-10-26 | Release date: | 2016-11-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters. Nat. Chem. Biol., 13, 2017
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5FN4
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![BU of 5fn4 by Molmil](/molmil-images/mine/5fn4) | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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4IRU
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![BU of 4iru by Molmil](/molmil-images/mine/4iru) | Crystal Structure of lepB GAP core in a transition state mimetic complex with Rab1A and ALF3 | Descriptor: | ACETATE ION, ALUMINUM FLUORIDE, GLYCEROL, ... | Authors: | Mishra, A.K, Delcampo, C.M, Collins, R.E, Roy, C.R, Lambright, D.G. | Deposit date: | 2013-01-15 | Release date: | 2013-07-10 | Last modified: | 2013-09-04 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism. J.Biol.Chem., 288, 2013
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3JWN
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![BU of 3jwn by Molmil](/molmil-images/mine/3jwn) | Complex of FimC, FimF, FimG and FimH | Descriptor: | Chaperone protein fimC, FimH protein, GLYCEROL, ... | Authors: | Le Trong, I, Aprikian, P, Stenkamp, R.E, Sokurenko, E.V. | Deposit date: | 2009-09-18 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like beta sheet twisting. Cell(Cambridge,Mass.), 141, 2010
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5HYG
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![BU of 5hyg by Molmil](/molmil-images/mine/5hyg) | CmlI (peroxo bound state), arylamine oxygenase of chloramphenicol biosynthetic pathway | Descriptor: | FE (III) ION, HYDROGEN PEROXIDE, L(+)-TARTARIC ACID, ... | Authors: | Knoot, C.J, Lipscomb, J.D. | Deposit date: | 2016-02-01 | Release date: | 2016-06-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway. J.Biol.Inorg.Chem., 21, 2016
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5HYH
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5FN3
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![BU of 5fn3 by Molmil](/molmil-images/mine/5fn3) | Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN2
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![BU of 5fn2 by Molmil](/molmil-images/mine/5fn2) | Cryo-EM structure of gamma secretase in complex with a drug DAPT | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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5FN5
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![BU of 5fn5 by Molmil](/molmil-images/mine/5fn5) | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | Descriptor: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | Authors: | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | Deposit date: | 2015-11-10 | Release date: | 2015-12-16 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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3EEV
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![BU of 3eev by Molmil](/molmil-images/mine/3eev) | Crystal Structure of Chloramphenicol Acetyltransferase VCA0300 from Vibrio cholerae O1 biovar eltor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Chloramphenicol acetyltransferase | Authors: | Kim, Y, Maltseva, N, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2008-09-05 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Crystal Structure of Chloramphenicol Acetyltransferase VCA0300 from Vibrio cholerae O1 biovar eltor To be Published
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2G5G
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4MXP
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![BU of 4mxp by Molmil](/molmil-images/mine/4mxp) | Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, Defects in Rab1 recruitment protein A, SODIUM ION | Authors: | Del Campo, C.M, Mishra, A.K, Wang, Y.H, Roy, C.R, Janmey, P.A, Lambright, D.G. | Deposit date: | 2013-09-26 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM. Structure, 22, 2014
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4M6E
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![BU of 4m6e by Molmil](/molmil-images/mine/4m6e) | The high resolution structure of tyrocidine A reveals an amphipathic dimer | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, METHANOL, tyrocidine A | Authors: | Loll, P.J, Economou, N.J, Nahoum, V. | Deposit date: | 2013-08-09 | Release date: | 2014-03-19 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | The high resolution structure of tyrocidine A reveals an amphipathic dimer. Biochim.Biophys.Acta, 1838, 2014
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6EE8
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![BU of 6ee8 by Molmil](/molmil-images/mine/6ee8) | Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter | Descriptor: | DNA (60-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. | Deposit date: | 2018-08-13 | Release date: | 2018-11-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
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8FS5
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![BU of 8fs5 by Molmil](/molmil-images/mine/8fs5) | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 3 (open 9-1-1 and stably bound chamber DNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | Deposit date: | 2023-01-09 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv, 2023
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