2I72

AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid

Summary for 2I72

• Entry DOI: 10.2210/pdb2i72/pdb
• Related: 1CB3 1KE4
• Descriptor: Beta-lactamase, {5-[(DIFORMYLAMINO)METHYL]-1-BENZOTHIEN-2-YL}BORONIC ACID (3 entities in total)
• Functional Keywords: ampc, beta-lactamase, cephalosporinase, serine hydrolase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79702.00

Authors

Venturelli, A.,Cancian, L.,Tondi, D.,Morandi, F.,Cannazza, G.,Segatore, B.,Prati, F.,Amicosante, G.,Shoichet, B.K.,Costi, M.P. (deposition date: 2006-08-30, release date: 2007-09-11, Last modification date: 2023-08-30)

• Primary citation: Venturelli, A.,Tondi, D.,Cancian, L.,Morandi, F.,Cannazza, G.,Segatore, B.,Prati, F.,Amicosante, G.,Shoichet, B.K.,Costi, M.P.; Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy; J.Med.Chem., 50:5644-5654, 2007; PubMed: 17956081; DOI: 10.1021/jm070643q

Experimental method

X-RAY DIFFRACTION (2.2 Å)