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7NGJ	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-(phenylmethyl)piperidine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGO	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, ~{N}-(furan-2-ylmethyl)-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGD	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-(4-phenylbutyl)piperidine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGR	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGS	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-pentyl-piperidine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGX	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-undecyl-pyridine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGK	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-cyclohexyl-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGN	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-cycloheptyl-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGT	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-butyl-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGU	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-(4-methoxyphenyl)-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGG	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, ~{N}-(4-chlorophenyl)-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGM	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-[(1~{R})-1-phenylethyl]piperidine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGI	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-[2-(2-fluorophenyl)ethyl]-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGY	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: 4-methyl-~{N}-[(~{E})-oct-5-enyl]piperidine-1-carboxamide, HTH-type transcriptional regulator EthR Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7NGW	Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-(4-hydroxyphenyl)-4-methyl-piperidine-1-carboxamide Authors: Tomlinson, C.W.E, Tatum, N.J, Pohl, E. Deposit date: 2021-02-09 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Systematic exploration of the hydrophobic capacity of the EthR binding site for lead compound optimization To Be Published
7EGF	TFIID lobe A subcomplex Descriptor: TATA-box-binding protein, Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 11, ... Authors: Chen, X, Wu, Z, Li, J, Zhao, D, Xu, Y. Deposit date: 2021-03-24 Release date: 2021-05-05 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Structural insights into preinitiation complex assembly on core promoters. Science, 2021
6ID1	Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... Authors: Zhang, X, Zhan, X, Yan, C, Shi, Y. Deposit date: 2018-09-07 Release date: 2019-03-13 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
2VP5	Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase Descriptor: 2'-DEOXYCYTIDINE, DEOXYNUCLEOSIDE KINASE, SULFATE ION Authors: Mikkelsen, N.E, Munch-Petersen, B, Eklund, H. Deposit date: 2008-02-26 Release date: 2008-04-18 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase. FEBS J., 275, 2008
5EYR	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 5 at 1.57A resolution Descriptor: 3-[1-[4-(methylaminomethyl)phenyl]piperidin-4-yl]-1-pyrrolidin-1-yl-propan-1-one, EthR Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-25 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.57 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
5F08	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution Descriptor: HTH-type transcriptional regulator EthR, ~{tert}-butyl ~{N}-methyl-~{N}-[[4-[4-(3-oxidanylidene-3-pyrrolidin-1-yl-propyl)piperidin-1-yl]phenyl]methyl]carbamate Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-27 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.92 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
5EZG	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 22 at 1.84A resolution Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-[(1-pyrimidin-2-ylpiperidin-4-yl)methyl]pyrrolidine-1-carboxamide Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-26 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.84 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
5F0H	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 28 at 1.99A resolution Descriptor: 3-[1-(4-cyanophenyl)piperidin-4-yl]-~{N}-[(4-piperidin-1-ylphenyl)methyl]propanamide, HTH-type transcriptional regulator EthR Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-27 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.99 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
5F1J	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 1 at 1.63A resolution Descriptor: 3-cyclopentyl-1-pyrrolidin-1-yl-propan-1-one, HTH-type transcriptional regulator EthR Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-30 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.631 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
5F0C	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 4 at 1.87A resolution Descriptor: 3-cyclopentyl-~{N}-(3-piperidin-1-ylphenyl)propanamide, HTH-type transcriptional regulator EthR, SULFATE ION Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-27 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.87 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016
5EZH	Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 21 at 1.7A resolution Descriptor: HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-[(1-pyridin-2-ylpiperidin-4-yl)methyl]pyrrolidine-1-carboxamide Authors: Surade, S, Blaszczyk, M, Nikiforov, P.O, Abell, C, Blundell, T.L. Deposit date: 2015-11-26 Release date: 2016-02-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14, 2016

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