PDB: 325 resultsInfo pagesStatus searchChemie searchBIRD

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6ONO	Complex structure of WhiB1 and region 4 of SigA in C2221 space group Descriptor: DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, RNA polymerase sigma factor SigA, ... Authors: Wan, T, Li, S.R, Beltran, D.G, Schacht, A, Becker, D.C, Zhang, L.M. Deposit date: 2019-04-22 Release date: 2019-11-27 Last modified: 2020-01-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural basis of non-canonical transcriptional regulation by the sigma A-bound iron-sulfur protein WhiB1 in M. tuberculosis. Nucleic Acids Res., 48, 2020
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKD	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKE	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKI	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
6OY7	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 7 min Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*TP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-14 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.04 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6OVY	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1C Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*TP*CP*TP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*CP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-08 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.999 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6OVR	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1G Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*GP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-08 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.843 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6OW3	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter variant -1T Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*TP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-09 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.766 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6OY6	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 5 min Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-14 Release date: 2019-06-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.096 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6OUL	Cryo-EM structure of Escherichia coli RNAP polymerase bound to rpsTP2 promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. Deposit date: 2019-05-04 Release date: 2020-02-26 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
6OY5	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 3 min Descriptor: DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*CP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*AP*T)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2019-05-14 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Res., 48, 2020
6P1K	Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. Deposit date: 2019-05-20 Release date: 2020-02-26 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.05 Å) Cite: E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
6LTS	Crystal structure of Thermus thermophilus transcription initiation complex comprising a truncated sigma finger Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2020-01-23 Release date: 2020-03-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.45 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
7KIF	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor Descriptor: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIM	Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor Descriptor: DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIN	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter Descriptor: DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
6KJ6	cryo-EM structure of Escherichia coli Crl transcription activation complex Descriptor: DNA (51-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Xu, J, Zhang, Y. Deposit date: 2019-07-21 Release date: 2020-01-01 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. Elife, 8, 2019
6M7J	Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin Descriptor: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-20 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
7N4E	Escherichia coli sigma 70-dependent paused transcription elongation complex Descriptor: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Su, M, Ebright, R.H. Deposit date: 2021-06-04 Release date: 2022-06-15 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
6N62	Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. Deposit date: 2018-11-24 Release date: 2019-01-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.803 Å) Cite: Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
7VWZ	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y, Shi, J. Deposit date: 2021-11-12 Release date: 2022-06-08 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
7VWY	Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y. Deposit date: 2021-11-12 Release date: 2022-06-08 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4.57 Å) Cite: Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator. Nucleic Acids Res., 50, 2022
4XLQ	Crystal structure of T.aquaticus transcription initiation complex containing upstream fork (-11 base-paired) promoter Descriptor: DNA (26-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-13 Release date: 2015-09-23 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (4.6 Å) Cite: Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
4XSZ	Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme Descriptor: 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-22 Release date: 2015-07-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.683 Å) Cite: CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015

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