PDB: 367 resultsInfo pagesStatus searchChemie searchBIRD

---

8G9V	Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 Descriptor: 17-beta-hydroxysteroid dehydrogenase 13, 4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Liu, S. Deposit date: 2023-02-22 Release date: 2023-08-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.645 Å) Cite: Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
4HX5	Crystal structure of 11 beta-HSD1 in complex with SAR184841 Descriptor: 4-[5-(4-tert-butylpiperazin-1-yl)pyridin-2-yl]-N-[(1R,2S,3S,5S,7s)-5-carbamoyltricyclo[3.3.1.1~3,7~]dec-2-yl]-3,4-dihydroquinoxaline-1(2H)-carboxamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Loenze, P, Schimanski-Breves, S, Engel, C.K. Deposit date: 2012-11-09 Release date: 2013-05-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Discovery of SAR184841, a potent and long-lasting inhibitor of 11beta-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D Bioorg.Med.Chem.Lett., 23, 2013
4HWK	Crystal structure of human sepiapterin reductase in complex with sulfapyridine Descriptor: 4-amino-N-(pyridin-2-yl)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Groenlund Pedersen, M, Pojer, F, Johnsson, K. Deposit date: 2012-11-08 Release date: 2013-06-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. Science, 340, 2013
8HI4	Cryo-EM structure of the bi-functional malonyl-CoA reductase from Roseiflexus castenholzii Descriptor: Short-chain dehydrogenase/reductase SDR Authors: Zhang, X, Xu, X, Xin, J. Deposit date: 2022-11-18 Release date: 2023-05-31 Last modified: 2023-09-20 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii. Mbio, 14, 2023
8HI6	Crystal structure of the NADP+ and MSA bound N terminal domain of bi-functional malonyl-CoA reductase from Roseiflexus castenholzii Descriptor: 3-oxidanylidenepropanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Zhang, X, Wu, W.P, Xu, X. Deposit date: 2022-11-18 Release date: 2023-05-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii. Mbio, 14, 2023
8HI5	Crystal structure of the NADP+ and MSA bound C terminal domain of bi-functional malonyl-CoA reductase from Roseiflexus castenholzii Descriptor: 3-oxidanylidenepropanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Zhang, X, Wu, W.P, Xu, X. Deposit date: 2022-11-18 Release date: 2023-05-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii. Mbio, 14, 2023
8HJW	Bi-functional malonyl-CoA reductuase from Chloroflexus aurantiacus Descriptor: Short-chain dehydrogenase/reductase SDR Authors: Ahn, J.W, Kim, S. Deposit date: 2022-11-24 Release date: 2023-08-30 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
4IJV	Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine Descriptor: 3-[1-(4-chlorophenyl)cyclopropyl]-8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sheriff, S. Deposit date: 2012-12-23 Release date: 2014-06-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014
4IJW	Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine Descriptor: 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sheriff, S. Deposit date: 2012-12-23 Release date: 2014-06-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014
4IJU	Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with (1S,4S)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol Descriptor: (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol, CHLORIDE ION, Corticosteroid 11-beta-dehydrogenase isozyme 1, ... Authors: Sheriff, S. Deposit date: 2012-12-23 Release date: 2014-06-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014
4IMR	Crystal structure of 3-oxoacyl (acyl-carrier-protein) reductase (target EFI-506442) from agrobacterium tumefaciens C58 with NADP bound Descriptor: 3-oxoacyl-(Acyl-carrier-protein) reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, UNKNOWN LIGAND Authors: Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Al Obaidi, N.F, Stead, M, Love, J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) Deposit date: 2013-01-03 Release date: 2013-01-16 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Crystal Structure of 3-Oxoacyl (Acyl-Carrier-Protein) Reductase Atu5465 from Agrobacterium Tumefaciens To be Published
4IS2	Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution Descriptor: Bile acid 3-alpha hydroxysteroid dehydrogenase, CHLORIDE ION Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2013-01-16 Release date: 2013-04-03 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution To be published
8I70	Crystal structure of NADP-binding form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Kim, S, Kim, K.-J. Deposit date: 2023-01-30 Release date: 2023-06-14 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
8I6Z	Crystal structure of apo-form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Kim, S, Kim, K.-J. Deposit date: 2023-01-30 Release date: 2023-06-14 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
4IS3	Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution Descriptor: ACETATE ION, Bile acid 3-alpha hydroxysteroid dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2013-01-16 Release date: 2013-04-24 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution To be published
4J7X	Crystal structure of human sepiapterin reductase in complex with sulfasalazine Descriptor: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Groenlund Pedersen, M, Pojer, F, Johnsson, K. Deposit date: 2013-02-14 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of human sepiapterin reductase in complex with sulfasalazine To be Published
8J29	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2D	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ Descriptor: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2B	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ and malonate Descriptor: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2A	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ Descriptor: GLYCEROL, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2C	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2E	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ and malonate Descriptor: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8JAT	Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans Descriptor: 3-ketodihydrosphingosine reductase TSC10, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Zhao, P, Kuang, Z. Deposit date: 2023-05-07 Release date: 2023-06-21 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans. Biochem.Biophys.Res.Commun., 670, 2023
4J7U	Crystal structure of human sepiapterin reductase in complex with sulfathiazole Descriptor: 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Groenlund Pedersen, M, Pojer, F, Johnsson, K. Deposit date: 2013-02-14 Release date: 2013-06-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. Science, 340, 2013
4K6C	X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia Descriptor: 1,2-ETHANEDIOL, Acetoacetyl-CoA reductase, CHLORIDE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-04-15 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia TO BE PUBLISHED

<23456789101112131415>