7B7S
 
 | | CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368 | | Descriptor: | 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, Cyclin-A2, Cyclin-dependent kinase 2, ... | | Authors: | Djukic, S, Skerlova, J, Rezacova, P. | | Deposit date: | 2020-12-11 | | Release date: | 2021-08-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
J.Med.Chem., 64, 2021
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3IB9
 | | Propionyl-CoA Carboxylase Beta Subunit, D422L | | Descriptor: | BIOTIN, Propionyl-CoA carboxylase complex B subunit, SULFATE ION | | Authors: | Diacovich, L, Arabolaza, A, Shillito, E.M, Lin, T.-W, Mitchell, D.L, Pham, H, Melgar, M.M. | | Deposit date: | 2009-07-15 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
Biochemistry, 49, 2010
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5Z1G
 | | Structure of the Brx1 and Ebp2 complex | | Descriptor: | Ribosome biogenesis protein BRX1, SULFATE ION, rRNA-processing protein EBP2 | | Authors: | Zheng, S, Ye, K. | | Deposit date: | 2017-12-26 | | Release date: | 2018-04-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.294 Å) | | Cite: | Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate
Protein Cell, 10, 2019
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7EMF
 | | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | | Descriptor: | Isoform 2 of Mediator of RNA polymerase II transcription subunit 16, Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, ... | | Authors: | Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. | | Deposit date: | 2021-04-13 | | Release date: | 2021-05-05 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
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3DWO
 | | Crystal structure of a Pseudomonas aeruginosa FadL homologue | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Probable outer membrane protein, SULFATE ION | | Authors: | Hearn, E.M, Patel, D.R, Lepore, B.W, Indic, M, van den Berg, B. | | Deposit date: | 2008-07-22 | | Release date: | 2008-12-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Transmembrane passage of hydrophobic compounds through a protein channel wall.
Nature, 458, 2009
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7ENJ
 | | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | | Descriptor: | Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... | | Authors: | Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. | | Deposit date: | 2021-04-17 | | Release date: | 2021-05-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
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3IAV
 | | Propionyl-CoA Carboxylase Beta Subunit, D422V | | Descriptor: | Propionyl-CoA carboxylase complex B subunit, SULFATE ION | | Authors: | Diacovich, L, Arabolaza, A, Shillito, E.M, Lin, T.-W, Mitchell, D.L, Pham, H, Melgar, M.M. | | Deposit date: | 2009-07-14 | | Release date: | 2010-06-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
Biochemistry, 49, 2010
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3PDM
 | | Hibiscus Latent Singapore virus | | Descriptor: | Coat protein, RNA (5'-R(P*GP*AP*A)-3') | | Authors: | Tewary, S.K, Wong, S.M, Swaminathan, K. | | Deposit date: | 2010-10-22 | | Release date: | 2011-01-12 | | Last modified: | 2024-03-20 | | Method: | FIBER DIFFRACTION (3.5 Å) | | Cite: | Structure of Hibiscus latent Singapore virus by fiber diffraction: A non-conserved His122 contributes to coat protein stability
J.Mol.Biol., 2010
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2NV4
 | | Crystal structure of UPF0066 protein AF0241 in complex with S-adenosylmethionine. Northeast Structural Genomics Consortium target GR27 | | Descriptor: | ACETATE ION, S-ADENOSYLMETHIONINE, UPF0066 protein AF_0241 | | Authors: | Kuzin, A.P, Abashidze, M, Seetharaman, J, Vorobiev, S.M, Fang, Y, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2006-11-10 | | Release date: | 2006-11-21 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Functional insights from structural genomics.
J.Struct.Funct.Genom., 8, 2007
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3DWN
 | | Crystal structure of the long-chain fatty acid transporter FadL mutant A77E/S100R | | Descriptor: | LAURYL DIMETHYLAMINE-N-OXIDE, Long-chain fatty acid transport protein | | Authors: | Hearn, E.M, Patel, D.R, Lepore, B.W, Indic, M, van den Berg, B. | | Deposit date: | 2008-07-22 | | Release date: | 2008-12-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Transmembrane passage of hydrophobic compounds through a protein channel wall.
Nature, 458, 2009
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2W8K
 | | Y-family DNA polymerase Dpo4 bypassing N2-naphthyl-guanine adduct in syn orientation | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*N2GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | | Authors: | Eoff, R.L, Zhang, H, Egli, M, Guengerich, F.P. | | Deposit date: | 2009-01-16 | | Release date: | 2009-01-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Versatility of Y-Family Sulfolobus Solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts.
J.Biol.Chem., 284, 2009
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2W8L
 | | Y-family DNA polymerase Dpo4 bypassing N2-naphthyl-guanine adduct in anti orientation | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*N2GP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ... | | Authors: | Eoff, R.L, Zhang, H, Egli, M, Guengerich, F.P. | | Deposit date: | 2009-01-16 | | Release date: | 2009-01-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Versatility of Y-Family Sulfolobus Solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts.
J.Biol.Chem., 284, 2009
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5B4E
 | | Sulfur Transferase TtuA in complex with iron sulfur cluster and ATP derivative | | Descriptor: | IRON/SULFUR CLUSTER, ISOPROPYL ALCOHOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Chen, M, Narai, S, Tanaka, Y, Yao, M. | | Deposit date: | 2016-04-03 | | Release date: | 2017-05-03 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.698 Å) | | Cite: | Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1TK0
 | | T7 DNA polymerase ternary complex with 8 oxo guanosine and ddCTP at the insertion site | | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(*CP*CP*CP*(8OG)P*CP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3', ... | | Authors: | Brieba, L.G, Eichman, B.F, Kokoska, R.J, Doublie, S, Kunkel, T.A, Ellenberger, T. | | Deposit date: | 2004-06-07 | | Release date: | 2004-08-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
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5AFQ
 | | Crystal structure of RPC62 - RPC32 beta | | Descriptor: | DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3, RPC32 BETA (RPC7L) | | Authors: | Fribourg, S. | | Deposit date: | 2015-01-23 | | Release date: | 2015-10-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (7 Å) | | Cite: | Structural Analysis of Human Rpc32Beta - Rpc62 Complex.
J.Struct.Biol., 192, 2015
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3QM4
 | | Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex | | Descriptor: | Cytochrome P450 2D6, NICKEL (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Wang, A, Stout, C.D, Johnson, E.F. | | Deposit date: | 2011-02-03 | | Release date: | 2012-02-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound.
J.Biol.Chem., 287, 2012
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3K8K
 | | Crystal structure of SusG | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Alpha-amylase, ... | | Authors: | Koropatkin, N.M, Smith, T.J. | | Deposit date: | 2009-10-14 | | Release date: | 2010-03-02 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | SusG: A Unique Cell-Membrane-Associated alpha-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules.
Structure, 18, 2010
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3R0R
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2ZU0
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7CVN
 | | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1 | | Authors: | Wang, X, Zhou, J, Xu, B. | | Deposit date: | 2020-08-26 | | Release date: | 2020-09-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors
Chinese journal of medicinal chemistry, 30, 2020
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1T8E
 | | T7 DNA Polymerase Ternary Complex with dCTP at the Insertion Site. | | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 25-MER, ... | | Authors: | Brieba, L.G, Eichman, B.F, Kokoska, R.J, Doublie, S, Kunkel, T.A, Ellenberger, T. | | Deposit date: | 2004-05-12 | | Release date: | 2004-10-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
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1TKD
 | | T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*CP*CP*CP*AP*(8OG)P*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*TP*CP*G)-3'), ... | | Authors: | Brieba, L.G, Eichman, B.F, Kokoska, R.J, Doublie, S, Kunkel, T.A, Ellenberger, T. | | Deposit date: | 2004-06-08 | | Release date: | 2004-08-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Embo J., 23, 2004
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3AHW
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3DG2
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5B4F
 | | Sulfur Transferase TtuA in complex with iron sulfur cluster | | Descriptor: | IRON/SULFUR CLUSTER, SULFATE ION, Sulfur Transferase TtuA, ... | | Authors: | Chen, M, Narai, S, Tanaka, Y, Yao, M. | | Deposit date: | 2016-04-03 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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