5LX2
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5LVZ
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5M37
| The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... | 著者 | Bier, D, Ottmann, C. | 登録日 | 2016-10-14 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
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5MHC
| Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ... | 著者 | Andrei, S, Ottmann, C, Leysen, S. | 登録日 | 2016-11-24 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
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5MYC
| Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. | 登録日 | 2017-01-26 | 公開日 | 2017-03-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.459 Å) | 主引用文献 | Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
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5MOC
| Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Andrei, S, Ottmann, C, Leysen, S. | 登録日 | 2016-12-14 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
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5MXO
| Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide stabilized by Fusicoccin-A | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... | 著者 | Andrei, S, Ottmann, C, Leysen, S. | 登録日 | 2017-01-24 | 公開日 | 2017-11-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
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5MY9
| Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. | 登録日 | 2017-01-26 | 公開日 | 2017-03-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.327 Å) | 主引用文献 | Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
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5N5T
| 14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV2 | 分子名称: | 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyphenol, CHLORIDE ION, ... | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | 登録日 | 2017-02-14 | 公開日 | 2017-07-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
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5N10
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5N5W
| 14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV3 | 分子名称: | 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyaniline, CALCIUM ION, ... | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | 登録日 | 2017-02-14 | 公開日 | 2017-07-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
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5N75
| 14-3-3 sigma in complex with TAZ pS89 peptide | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | 登録日 | 2017-02-19 | 公開日 | 2017-07-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
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5N5R
| 14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV1 | 分子名称: | 14-3-3 protein sigma, 2-azanyl-~{N}-(2,6-dimethylphenyl)-~{N}-propan-2-yl-ethanamide, CHLORIDE ION, ... | 著者 | Sijbesma, E, Leysen, S, Ottmann, C. | 登録日 | 2017-02-14 | 公開日 | 2017-07-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
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5NAS
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6EF5
| 14-3-3 with peptide | 分子名称: | 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN | 著者 | Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W. | 登録日 | 2018-08-16 | 公開日 | 2019-10-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | 14-3-3 with peptide To Be Published
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6EJL
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6EIH
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6EWW
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6F08
| 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1) | 分子名称: | 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1 | 著者 | Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S. | 登録日 | 2017-11-17 | 公開日 | 2018-02-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1). J. Struct. Biol., 202, 2018
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6FAU
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{R})-(2-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-18 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FI4
| Crystal structure of C-terminal modified Tau peptide-hybrid 3.2e with 14-3-3sigma | 分子名称: | (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CALCIUM ION, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2018-01-17 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FBB
| Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Leysen, S, Meijer, F.A, Milroy, L.G, Ottmann, C. | 登録日 | 2017-12-18 | 公開日 | 2018-03-14 | 最終更新日 | 2018-05-09 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD. J. Am. Soc. Nephrol., 29, 2018
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6FAV
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-I with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{R})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-18 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FBY
| Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma | 分子名称: | (2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2017-12-20 | 公開日 | 2018-05-16 | 最終更新日 | 2019-02-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FI5
| Crystal structure of C-terminal modified Tau peptide-hybrid 3.2d with 14-3-3sigma | 分子名称: | (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | 登録日 | 2018-01-17 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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