PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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5VKO	SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493 Descriptor: DNA-directed RNA polymerase II subunit RPB1, ISOPROPYL ALCOHOL, Transcription elongation factor SPT6 Authors: Sdano, M.A, Whitby, F.G, Hill, C.P. Deposit date: 2017-04-21 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
5VKL	SPT6 tSH2-RPB1 1476-1500 pS1493 Descriptor: DNA-directed RNA polymerase II subunit RPB1, Transcription elongation factor SPT6 Authors: Sdano, M.A, Whitby, F.G, Hill, C.P. Deposit date: 2017-04-21 Release date: 2017-10-25 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.198 Å) Cite: A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
5W3R	SH2B1 SH2 Domain Descriptor: PHENOL, PHOSPHATE ION, SH2B adapter protein 1 Authors: McKercher, M.A, Wuttke, D.S. Deposit date: 2017-06-08 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.386 Å) Cite: Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
1A1A	C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A08	C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) Descriptor: ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-09 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A09	C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine) Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A1E	C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE) Descriptor: ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A1B	C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) Descriptor: ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A07	C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE) Descriptor: ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-09 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1A1C	C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL)) Descriptor: ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL)), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1AB2	THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL Descriptor: C-ABL TYROSINE KINASE SH2 DOMAIN Authors: Overduin, M, Rios, C.B, Mayer, B.J, Baltimore, D, Cowburn, D. Deposit date: 1993-07-19 Release date: 1994-01-31 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Three-dimensional solution structure of the src homology 2 domain of c-abl. Cell(Cambridge,Mass.), 70, 1992
1AYB	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE Descriptor: PEPTIDE IRS-1-895, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1994-05-15 Release date: 1994-08-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
1AOT	NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE Descriptor: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE Authors: Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D. Deposit date: 1997-07-10 Release date: 1998-01-14 Last modified: 2021-11-03 Method: SOLUTION NMR Cite: The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure, 5, 1997
1AYC	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE Descriptor: PEPTIDE PDGFR-740, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1994-05-15 Release date: 1994-08-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
1AYA	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE Descriptor: PEPTIDE PDGFR-1009, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1994-05-15 Release date: 1994-08-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
1BHF	P56LCK SH2 DOMAIN INHIBITOR COMPLEX Descriptor: INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK Authors: Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. Deposit date: 1998-06-08 Release date: 1998-10-21 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. J.Biol.Chem., 273, 1998
1BFJ	SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE Descriptor: P85 ALPHA Authors: Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. Deposit date: 1997-11-18 Release date: 1998-02-25 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase. J.Mol.Biol., 276, 1998
1AOU	NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES Descriptor: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE Authors: Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D. Deposit date: 1997-07-10 Release date: 1998-01-14 Last modified: 2021-11-03 Method: SOLUTION NMR Cite: The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure, 5, 1997
1BFI	SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES Descriptor: P85 ALPHA Authors: Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. Deposit date: 1997-11-18 Release date: 1998-02-25 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase. J.Mol.Biol., 276, 1998
1BHH	FREE P56LCK SH2 DOMAIN Descriptor: P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK Authors: Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. Deposit date: 1998-06-08 Release date: 1998-10-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. J.Biol.Chem., 273, 1998
1AYD	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE Descriptor: PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1994-05-15 Release date: 1994-08-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
1BLJ	NMR ENSEMBLE OF BLK SH2 DOMAIN, 20 STRUCTURES Descriptor: P55 BLK PROTEIN TYROSINE KINASE Authors: Metzler, W.J, Leiting, B, Pryor, K, Mueller, L, Farmer II, B.T. Deposit date: 1996-03-26 Release date: 1997-03-12 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: The three-dimensional solution structure of the SH2 domain from p55blk kinase. Biochemistry, 35, 1996
1BMB	GRB2-SH2 DOMAIN IN COMPLEX WITH KPFY*VNVEF (PKF270-974) Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF270-974) Authors: Rondeau, J.M, Zurini, M. Deposit date: 1998-07-23 Release date: 1998-07-29 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J.Med.Chem., 42, 1999
1BM2	GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791) Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF273-791) Authors: Rondeau, J.M, Zurini, M. Deposit date: 1998-07-27 Release date: 1998-08-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J.Med.Chem., 42, 1999
1BLK	NMR ENSEMBLE OF BLK SH2 DOMAIN USING CHEMICAL SHIFT REFINEMENT, 20 STRUCTURES Descriptor: P55 BLK PROTEIN TYROSINE KINASE Authors: Metzler, W.J, Leiting, B, Pryor, K, Mueller, L, Farmer II, B.T. Deposit date: 1996-03-26 Release date: 1997-03-12 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: The three-dimensional solution structure of the SH2 domain from p55blk kinase. Biochemistry, 35, 1996

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