8DGS
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![BU of 8dgs by Molmil](/molmil-images/mine/8dgs) | Cryo-EM structure of a RAS/RAF complex (state 1) | Descriptor: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Eck, M.J, Jeon, H, Park, E, Rawson, S. | Deposit date: | 2022-06-24 | Release date: | 2023-07-05 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
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2W1C
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![BU of 2w1c by Molmil](/molmil-images/mine/2w1c) | Structure determination of Aurora Kinase in complex with inhibitor | Descriptor: | 4-{[2-(4-{[(4-FLUOROPHENYL)CARBONYL]AMINO}-1H-PYRAZOL-3-YL)-1H-BENZIMIDAZOL-6-YL]METHYL}MORPHOLIN-4-IUM, SERINE/THREONINE-PROTEIN KINASE 6 | Authors: | Howard, S, Berdini, V, Boulstridge, J.A, Carr, M.G, Cross, D.M, Curry, J, Devine, L.A, Early, T.R, Fazal, L, Gill, A.L, Heathcote, M, Maman, S, Matthews, J.E, McMenamin, R.L, Navarro, E.F, O'Brien, M.A, O'Reilly, M, Rees, D.C, Reule, M, Tisi, D, Williams, G, Vinkovic, M, Wyatt, P.G. | Deposit date: | 2008-10-17 | Release date: | 2009-01-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. J.Med.Chem., 52, 2009
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8DGT
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![BU of 8dgt by Molmil](/molmil-images/mine/8dgt) | Cryo-EM structure of a RAS/RAF complex (state 2) | Descriptor: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Eck, M.J, Jeon, H, Park, E, Rawson, S. | Deposit date: | 2022-06-24 | Release date: | 2023-07-05 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
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2J0Q
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![BU of 2j0q by Molmil](/molmil-images/mine/2j0q) | The crystal structure of the Exon Junction Complex at 3.2 A resolution | Descriptor: | 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3', ATP-DEPENDENT RNA HELICASE DDX48, MAGNESIUM ION, ... | Authors: | Bono, F, Ebert, J, Lorentzen, E, Conti, E. | Deposit date: | 2006-08-04 | Release date: | 2006-08-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on Mrna. Cell(Cambridge,Mass.), 126, 2006
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2Y57
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![BU of 2y57 by Molmil](/molmil-images/mine/2y57) | Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 4) | Descriptor: | CHLORIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION, ... | Authors: | Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. | Deposit date: | 2011-01-12 | Release date: | 2011-06-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
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6PQL
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![BU of 6pql by Molmil](/molmil-images/mine/6pql) | SBP RafE in complex with raffinose | Descriptor: | ABC transporter sugar-binding protein, beta-D-fructofuranose-(2-1)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose | Authors: | Meier, E.P.W, Boraston, A.B. | Deposit date: | 2019-07-09 | Release date: | 2019-10-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Molecular analysis of an enigmaticStreptococcus pneumoniaevirulence factor: The raffinose-family oligosaccharide utilization system. J.Biol.Chem., 294, 2019
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6F9K
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6V4M
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![BU of 6v4m by Molmil](/molmil-images/mine/6v4m) | Trichuris suis BCL-2 | Descriptor: | BCL-2, CHLORIDE ION, SULFATE ION | Authors: | Fairlie, W.D, Lee, E.F, Smith, B.J. | Deposit date: | 2019-11-28 | Release date: | 2020-10-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Diversity in the intrinsic apoptosis pathway of nematodes. Commun Biol, 3, 2020
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7B75
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![BU of 7b75 by Molmil](/molmil-images/mine/7b75) | Cryo-EM Structure of Human Thyroglobulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, ... | Authors: | Adaixo, R, Righetto, R, Steiner, E.M, Taylor, N.M.I, Stahlberg, H. | Deposit date: | 2020-12-09 | Release date: | 2021-12-29 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of native human thyroglobulin. Nat Commun, 13, 2022
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6V9V
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![BU of 6v9v by Molmil](/molmil-images/mine/6v9v) | Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily A member 1, ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide | Authors: | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | Deposit date: | 2019-12-16 | Release date: | 2020-05-06 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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3E1N
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![BU of 3e1n by Molmil](/molmil-images/mine/3e1n) | Crystal structure of E. coli Bacterioferritin (BFR) after a 65 minute (aerobic) exposure to FE(II) revealing a possible MU-OXO bridge/MU-Hydroxy bridged DIIRON intermediate at the ferroxidase centre. (FE(III)-O-FE(III)-BFR). | Descriptor: | BACTERIOFERRITIN, FE (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Crow, A, Lawson, T, Lewin, A, Moore, G.R, Le Brun, N. | Deposit date: | 2008-08-04 | Release date: | 2009-05-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for iron mineralization by bacterioferritin J.Am.Chem.Soc., 131, 2009
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2Y54
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![BU of 2y54 by Molmil](/molmil-images/mine/2y54) | Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Fragment 1) | Descriptor: | CHLORIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION, ... | Authors: | Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. | Deposit date: | 2011-01-12 | Release date: | 2011-06-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
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6VGW
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![BU of 6vgw by Molmil](/molmil-images/mine/6vgw) | Crystal structure of VidaL intein (selenomethionine variant) | Descriptor: | GLYCEROL, SULFATE ION, VidaL | Authors: | Burton, A.J, Haugbro, M, Parisi, E, Muir, T.W. | Deposit date: | 2020-01-09 | Release date: | 2020-05-27 | Last modified: | 2020-06-17 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Live-cell protein engineering with an ultra-short split intein. Proc.Natl.Acad.Sci.USA, 117, 2020
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6FDP
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2J1K
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![BU of 2j1k by Molmil](/molmil-images/mine/2j1k) | CAV-2 fibre head in complex with CAR D1 | Descriptor: | COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR, FIBER PROTEIN | Authors: | Seiradake, E, Lortat-Jacob, H, Billet, O, Kremer, E.J, Cusack, S. | Deposit date: | 2006-08-14 | Release date: | 2006-09-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Mutational Analysis of Human Ad37 and Canine Adenovirus 2 Fiber Heads in Complex with the D1 Domain of Coxsackie and Adenovirus Receptor. J.Biol.Chem., 281, 2006
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5TUB
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![BU of 5tub by Molmil](/molmil-images/mine/5tub) | Crystal Structure of the Shark TBC1D15 GAP Domain | Descriptor: | Shark TBC1D15 GTPase-activating Protein | Authors: | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | Deposit date: | 2016-11-05 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci., 26, 2017
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8CPB
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![BU of 8cpb by Molmil](/molmil-images/mine/8cpb) | 1,6-anhydro-n-actetylmuramic acid kinase (AnmK) in complex with AMPPNP, and AnhMurNAc at 1.7 Angstroms resolution. | Descriptor: | 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, Anhydro-N-acetylmuramic acid kinase, GLYCEROL, ... | Authors: | Jimenez-Faraco, E, Hermoso, J.A. | Deposit date: | 2023-03-02 | Release date: | 2023-09-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Catalytic process of anhydro-N-acetylmuramic acid kinase from Pseudomonas aeruginosa. J.Biol.Chem., 299, 2023
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8C54
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![BU of 8c54 by Molmil](/molmil-images/mine/8c54) | Cryo-EM structure of NADH bound SLA dehydrogenase RlGabD from Rhizobium leguminosarum bv. trifolii SRD1565 | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Succinate semialdehyde dehydrogenase | Authors: | Sharma, M, Meek, R.W, Armstrong, Z, Blaza, J.N, Alhifthi, A, Li, J, Goddard-Borger, E.D, Williams, S.J, Davies, G.J. | Deposit date: | 2023-01-06 | Release date: | 2023-09-20 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum. Chem Sci, 14, 2023
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8CP9
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8C3U
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![BU of 8c3u by Molmil](/molmil-images/mine/8c3u) | Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist | Descriptor: | (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid, Interleukin-1 beta | Authors: | Rondeau, J.-M, Lehmann, S, Koch, E. | Deposit date: | 2022-12-28 | Release date: | 2023-09-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.945 Å) | Cite: | Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta. Nat Commun, 14, 2023
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8C0U
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![BU of 8c0u by Molmil](/molmil-images/mine/8c0u) | 1,6-anhydro-n-actetylmuramic acid kinase (AnmK) in complex with their natural substrates and products | Descriptor: | (2~{R})-2-[(2~{S},3~{R},4~{R},5~{S},6~{R})-3-acetamido-2,5-bis(oxidanyl)-6-(phosphonooxymethyl)oxan-4-yl]oxypropanoic acid, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Jimenez-Faraco, E, Hermoso, J.A. | Deposit date: | 2022-12-19 | Release date: | 2023-09-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.112 Å) | Cite: | Catalytic process of anhydro-N-acetylmuramic acid kinase from Pseudomonas aeruginosa. J.Biol.Chem., 299, 2023
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5U03
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![BU of 5u03 by Molmil](/molmil-images/mine/5u03) | Cryo-EM structure of the human CTP synthase filament | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase 1, URIDINE 5'-TRIPHOSPHATE | Authors: | Lynch, E.M, Kollman, J.M. | Deposit date: | 2016-11-22 | Release date: | 2017-04-26 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Human CTP synthase filament structure reveals the active enzyme conformation. Nat. Struct. Mol. Biol., 24, 2017
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6V6Q
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![BU of 6v6q by Molmil](/molmil-images/mine/6v6q) | Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657 | Descriptor: | Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Lin, C.-C, Wieteska, L, Poncet-Montange, G, Suen, K.M, Arold, S.T, Ahmed, Z, Ladbury, J.E. | Deposit date: | 2019-12-05 | Release date: | 2020-11-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | The combined action of the intracellular regions regulates FGFR2 kinase activity Commun Biol, 6, 2023
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6HIQ
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![BU of 6hiq by Molmil](/molmil-images/mine/6hiq) | Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | Deposit date: | 2018-08-30 | Release date: | 2018-11-07 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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8BRX
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![BU of 8brx by Molmil](/molmil-images/mine/8brx) | Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C complexed with beta-3-methionine | Descriptor: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ... | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | Deposit date: | 2022-11-24 | Release date: | 2023-08-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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