8C3U
Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist
Summary for 8C3U
| Entry DOI | 10.2210/pdb8c3u/pdb |
| Descriptor | Interleukin-1 beta, (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid (3 entities in total) |
| Functional Keywords | beta trefoil fold; secreted, cytokine |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 35730.56 |
| Authors | Rondeau, J.-M.,Lehmann, S.,Koch, E. (deposition date: 2022-12-28, release date: 2023-09-13, Last modification date: 2024-03-27) |
| Primary citation | Hommel, U.,Hurth, K.,Rondeau, J.M.,Vulpetti, A.,Ostermeier, D.,Boettcher, A.,Brady, J.P.,Hediger, M.,Lehmann, S.,Koch, E.,Blechschmidt, A.,Yamamoto, R.,Tundo Dottorello, V.,Haenni-Holzinger, S.,Kaiser, C.,Lehr, P.,Lingel, A.,Mureddu, L.,Schleberger, C.,Blank, J.,Ramage, P.,Freuler, F.,Eder, J.,Bornancin, F. Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta. Nat Commun, 14:5497-5497, 2023 Cited by PubMed: 37679328DOI: 10.1038/s41467-023-41190-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.945 Å) |
Structure validation
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