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8C3U

Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005615cellular_componentextracellular space
A0006954biological_processinflammatory response
A0006955biological_processimmune response
B0005125molecular_functioncytokine activity
B0005615cellular_componentextracellular space
B0006954biological_processinflammatory response
B0006955biological_processimmune response
Functional Information from PROSITE/UniProt
site_idPS00253
Number of Residues21
DetailsINTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV
ChainResidueDetails
APHE112-VAL132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Involved in receptor binding
ChainResidueDetails
AARG4
BARG4

site_idSWS_FT_FI2
Number of Residues10
DetailsSITE: Important for interaction with integrin => ECO:0000269|PubMed:29030430
ChainResidueDetails
ALYS55
BLYS88
ALYS63
ALYS65
ALYS74
ALYS88
BLYS55
BLYS63
BLYS65
BLYS74

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PDB entries from 2024-07-24

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