7KIM
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![BU of 7kim by Molmil](/molmil-images/mine/7kim) | Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor | Descriptor: | DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2020-10-23 | Release date: | 2021-04-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
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7KIF
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![BU of 7kif by Molmil](/molmil-images/mine/7kif) | Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor | Descriptor: | DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2020-10-23 | Release date: | 2021-04-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
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7KIN
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![BU of 7kin by Molmil](/molmil-images/mine/7kin) | Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter | Descriptor: | DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Lilic, M, Darst, S.A, Campbell, E.A. | Deposit date: | 2020-10-23 | Release date: | 2021-04-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
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5X21
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![BU of 5x21 by Molmil](/molmil-images/mine/5x21) | Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) | Descriptor: | (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Zhang, Y, Ebright, R. | Deposit date: | 2017-01-29 | Release date: | 2017-07-05 | Last modified: | 2022-10-12 | Method: | X-RAY DIFFRACTION (3.323 Å) | Cite: | Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
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7KHC
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![BU of 7khc by Molmil](/molmil-images/mine/7khc) | Escherichia coli RNA polymerase and rrnBP1 promoter closed complex | Descriptor: | CHAPSO, DNA (18 MER), DNA (63-MER), ... | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | Deposit date: | 2020-10-20 | Release date: | 2020-10-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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8K60
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![BU of 8k60 by Molmil](/molmil-images/mine/8k60) | |
7KHI
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![BU of 7khi by Molmil](/molmil-images/mine/7khi) | Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp | Descriptor: | CHAPSO, DNA (28-MER), DNA (36-MER), ... | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | Deposit date: | 2020-10-21 | Release date: | 2020-10-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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7L7B
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![BU of 7l7b by Molmil](/molmil-images/mine/7l7b) | Clostridioides difficile RNAP with fidaxomicin | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. | Deposit date: | 2020-12-28 | Release date: | 2022-02-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
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5ZX3
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![BU of 5zx3 by Molmil](/molmil-images/mine/5zx3) | |
5ZX2
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![BU of 5zx2 by Molmil](/molmil-images/mine/5zx2) | |
8U3B
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![BU of 8u3b by Molmil](/molmil-images/mine/8u3b) | Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A | Descriptor: | DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Kompaniiets, D, Wang, D. | Deposit date: | 2023-09-07 | Release date: | 2024-01-17 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural basis for transcription activation by the nitrate-responsive regulator NarL. Nucleic Acids Res., 52, 2024
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8TO8
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![BU of 8to8 by Molmil](/molmil-images/mine/8to8) | Escherichia coli RNA polymerase unwinding intermediate (I1b) at the lambda PR promoter | Descriptor: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Darst, S.A, Saecker, R.M, Mueller, A.U. | Deposit date: | 2023-08-03 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 2024
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8TOM
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![BU of 8tom by Molmil](/molmil-images/mine/8tom) | |
8TO1
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![BU of 8to1 by Molmil](/molmil-images/mine/8to1) | Escherichia coli RNA polymerase unwinding intermediate (I1a) at the lambda PR promoter | Descriptor: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Darst, S.A, Saecker, R.M, Mueller, A.U. | Deposit date: | 2023-08-02 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 2024
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8TOE
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![BU of 8toe by Molmil](/molmil-images/mine/8toe) | |
8TO6
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![BU of 8to6 by Molmil](/molmil-images/mine/8to6) | Escherichia coli RNA polymerase unwinding intermediate (I1d) at the lambda PR promoter | Descriptor: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Darst, S.A, Saecker, R.M, Mueller, A.U. | Deposit date: | 2023-08-02 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 2024
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8X6F
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![BU of 8x6f by Molmil](/molmil-images/mine/8x6f) | Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex | Descriptor: | DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yuan, L, Xu, L, Liu, Q, Feng, Y. | Deposit date: | 2023-11-21 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
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8X6G
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![BU of 8x6g by Molmil](/molmil-images/mine/8x6g) | Cryo-EM structure of Staphylococcus aureus sigB-dependent RNAP-promoter open complex | Descriptor: | DNA (70-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yuan, L, Xu, L, Liu, Q, Feng, Y. | Deposit date: | 2023-11-21 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
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8W8O
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![BU of 8w8o by Molmil](/molmil-images/mine/8w8o) | |
8W8P
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![BU of 8w8p by Molmil](/molmil-images/mine/8w8p) | |
8W8N
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![BU of 8w8n by Molmil](/molmil-images/mine/8w8n) | |
4KN7
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![BU of 4kn7 by Molmil](/molmil-images/mine/4kn7) | |
4MEY
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![BU of 4mey by Molmil](/molmil-images/mine/4mey) | Crystal structure of Escherichia coli RNA polymerase holoenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. | Deposit date: | 2013-08-27 | Release date: | 2014-05-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.948 Å) | Cite: | Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife, 3, 2014
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6B6H
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![BU of 6b6h by Molmil](/molmil-images/mine/6b6h) | The cryo-EM structure of a bacterial class I transcription activation complex | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. | Deposit date: | 2017-10-02 | Release date: | 2017-11-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of bacterial transcription activation. Science, 358, 2017
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4LK1
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![BU of 4lk1 by Molmil](/molmil-images/mine/4lk1) | Crystal Structure Analysis of the E.coli holoenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Bae, B, Darst, S.A. | Deposit date: | 2013-07-05 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.8369 Å) | Cite: | Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA, 110, 2013
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