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7AB4
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BU of 7ab4 by Molmil
Crystal structure of the Escherichia coli toxin-antitoxin system HipBST (HipT S59A)
Descriptor: Couple_hipA domain-containing protein, HipA_C domain-containing protein, Predicted transcriptional regulator, ...
Authors:Baerentsen, R.L, Brodersen, D.E.
Deposit date:2020-09-06
Release date:2022-01-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Structural basis for regulation of a tripartite toxin-antitoxin system by dual phosphorylation
Biorxiv, 2022
7AB3
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BU of 7ab3 by Molmil
Crystal structure of the Escherichia coli toxin-antitoxin system HipBST (HipT S57A)
Descriptor: Couple_hipA domain-containing protein, HipA_C domain-containing protein, Predicted transcriptional regulator, ...
Authors:Baerentsen, R.L, Brodersen, D.E.
Deposit date:2020-09-06
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for regulation of a tripartite toxin-antitoxin system by dual phosphorylation
Biorxiv, 2022
2WIU
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BU of 2wiu by Molmil
Mercury-modified bacterial persistence regulator hipBA
Descriptor: CHLORIDE ION, HTH-TYPE TRANSCRIPTIONAL REGULATOR HIPB, MERCURY (II) ION, ...
Authors:Evdokimov, A, Voznesensky, I, Fennell, K, Anderson, M, Smith, J.F, Fisher, D.A.
Deposit date:2009-05-17
Release date:2009-07-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:New Kinase Regulation Mechanism Found in Hipba: A Bacterial Persistence Switch.
Acta Crystallogr.,Sect.D, 65, 2009
6AF4
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BU of 6af4 by Molmil
Toxin-Antitoxin module from Streptococcus pneumoniae
Descriptor: HigA antitoxin, HigB toxin
Authors:Kang, S.M, Kim, D.H, Jin, C.
Deposit date:2018-08-08
Release date:2019-08-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Toxin-Antitoxin module from Streptococcus pneumoniae
To Be Published
6KML
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BU of 6kml by Molmil
2.09 Angstrom resolution crystal structure of tetrameric HigBA toxin-antitoxin complex from E.coli
Descriptor: Antitoxin HigA, mRNA interferase toxin HigB
Authors:Jadhav, P, Sinha, V.K, Rothweiler, U, Singh, M.
Deposit date:2019-07-31
Release date:2020-11-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:2.09 angstrom Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.
Biochem.J., 477, 2020
6KMQ
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BU of 6kmq by Molmil
2.3 Angstrom resolution structure of dimeric HigBA toxin-antitoxin complex from E. coli
Descriptor: Antitoxin HigA, mRNA interferase toxin HigB
Authors:Jadhav, P, Sinha, V.K, Rothweiler, U, Singh, M.
Deposit date:2019-07-31
Release date:2020-11-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2.09 angstrom Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin.
Biochem.J., 477, 2020
6AF3
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BU of 6af3 by Molmil
Toxin-Antitoxin module from Streptococcus pneumoniae
Descriptor: HigA antitoxin, HigB toxin
Authors:Kang, S.M, Kim, D.H, Jin, C.
Deposit date:2018-08-08
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Toxin-Antitoxin module from Streptococcus pneumoniae
To Be Published
2P5T
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BU of 2p5t by Molmil
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae
Descriptor: PezT, Putative transcriptional regulator PezA, fragment of PezA helix-turn-helix motif
Authors:Loll, B, Meinhart, A.
Deposit date:2007-03-16
Release date:2007-05-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular and Structural Characterization of the PezAT Chromosomal Toxin-Antitoxin System of the Human Pathogen Streptococcus pneumoniae.
J.Biol.Chem., 282, 2007
2QFC
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BU of 2qfc by Molmil
Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR
Descriptor: C-terminus pentapeptide from PapR protein, DI(HYDROXYETHYL)ETHER, PlcR protein
Authors:Declerck, N, Chaix, D, Rugani, N, Hoh, F, Arold, S.T.
Deposit date:2007-06-27
Release date:2007-11-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria
Proc.Natl.Acad.Sci.Usa, 104, 2007
3DNV
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BU of 3dnv by Molmil
MDT Protein
Descriptor: DNA (5'-D(*DAP*DCP*DTP*DAP*DTP*DCP*DCP*DCP*DCP*DTP*DTP*DAP*DAP*DGP*DGP*DGP*DGP*DAP*DTP*DAP*DG)-3'), HTH-type transcriptional regulator hipB, Protein hipA, ...
Authors:schumacher, M.A.
Deposit date:2008-07-02
Release date:2009-01-27
Last modified:2023-04-05
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science, 323, 2009
4MCT
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BU of 4mct by Molmil
P. vulgaris HIGBA structure, crystal form 1
Descriptor: Antidote protein, Killer protein
Authors:Schureck, M.A, Maehigashi, T, Dunham, C.M.
Deposit date:2013-08-21
Release date:2013-12-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Proteus vulgaris HigB-(HigA)2-HigB Toxin-Antitoxin Complex.
J.Biol.Chem., 289, 2014
4MCX
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BU of 4mcx by Molmil
P. vulgaris HIGBA structure, crystal form 2
Descriptor: Antidote protein, Killer protein
Authors:Schureck, M.A, Maehigashi, T, Dunham, C.M.
Deposit date:2013-08-21
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the Proteus vulgaris HigB-(HigA)2-HigB Toxin-Antitoxin Complex.
J.Biol.Chem., 289, 2014
6HPB
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BU of 6hpb by Molmil
Crystal structure of the E.coli HicAB toxin-antitoxin complex
Descriptor: Antitoxin HicB, SULFATE ION, mRNA interferase toxin HicA
Authors:Manav, M.C, Brodersen, D.E.
Deposit date:2018-09-20
Release date:2019-09-18
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain.
Structure, 27, 2019
6HPC
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BU of 6hpc by Molmil
Crystal structure of the HicB antitoxin from E. coli
Descriptor: Antitoxin HicB
Authors:Manav, M.C, Brodersen, D.E.
Deposit date:2018-09-20
Release date:2019-09-18
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain.
Structure, 27, 2019
1RIO
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BU of 1rio by Molmil
Structure of bacteriophage lambda cI-NTD in complex with sigma-region4 of Thermus aquaticus bound to DNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 27-MER, CALCIUM ION, ...
Authors:Jain, D, Nickels, B.E, Sun, L, Hochschild, A, Darst, S.A.
Deposit date:2003-11-17
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a ternary transcription activation complex.
Mol.Cell, 13, 2004
4PU3
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BU of 4pu3 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P212121)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
2GRL
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BU of 2grl by Molmil
Crystal structure of dCT/iCF10 complex
Descriptor: PrgX, peptide
Authors:Shi, K, Kozlowicz, B.K, Gu, Z.Y, Ohlendorf, D.H, Earhart, C.A, Dunny, G.M.
Deposit date:2006-04-24
Release date:2007-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides.
Mol.Microbiol., 62, 2006
4PU4
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BU of 4pu4 by Molmil
Shewanella oneidensis MR-1 Toxin Antitoxin System HipA, HipB and its operator DNA complex (space group P21)
Descriptor: Operator DNA, Toxin-antitoxin system antidote transcriptional repressor Xre family, Toxin-antitoxin system toxin HipA family
Authors:Wen, Y, Behiels, E, Felix, J, Elegheert, J, Vergauwen, B, Devreese, B, Savvides, S.
Deposit date:2014-03-12
Release date:2014-08-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.786 Å)
Cite:The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res., 42, 2014
2GRM
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BU of 2grm by Molmil
Crystal structure of PrgX/iCF10 complex
Descriptor: PrgX, peptide
Authors:Shi, K, Kozlowicz, B.K, Gu, Z.Y, Ohlendorf, D.H, Earhart, C.A, Dunny, G.M.
Deposit date:2006-04-24
Release date:2007-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides.
Mol.Microbiol., 62, 2006
3SCH
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BU of 3sch by Molmil
Co(II)-HppE with R-HPP
Descriptor: COBALT (II) ION, Epoxidase, [(2R)-2-hydroxypropyl]phosphonic acid
Authors:Drennan, C.L.
Deposit date:2011-06-07
Release date:2011-07-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
3SCF
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BU of 3scf by Molmil
Fe(II)-HppE with S-HPP and NO
Descriptor: (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, Epoxidase, FE (II) ION, ...
Authors:Drennan, C.L.
Deposit date:2011-06-07
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
3SCG
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BU of 3scg by Molmil
Fe(II)-HppE with R-HPP
Descriptor: Epoxidase, FE (II) ION, [(2R)-2-hydroxypropyl]phosphonic acid
Authors:Drennan, C.L.
Deposit date:2011-06-07
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
3U3W
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BU of 3u3w by Molmil
Crystal Structure of Bacillus thuringiensis PlcR in complex with the peptide PapR7 and DNA
Descriptor: 5'-D(P*AP*TP*AP*TP*GP*AP*AP*AP*TP*AP*TP*TP*GP*CP*AP*TP*AP*G)-3', 5'-D(P*CP*TP*AP*TP*GP*CP*AP*AP*TP*AP*TP*TP*TP*CP*AP*TP*AP*T)-3', C-terminus heptapeptide from PapR protein, ...
Authors:Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S.
Deposit date:2011-10-06
Release date:2013-01-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J1X
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BU of 4j1x by Molmil
Crystal Structure of Fe(II)-HppE with alternative substrate (S)-1-HPP
Descriptor: Epoxidase, FE (II) ION, GLYCEROL, ...
Authors:Drennan, C.L, Dey, M.
Deposit date:2013-02-03
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.
Nature, 496, 2013
4J1W
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BU of 4j1w by Molmil
Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP
Descriptor: Epoxidase, FE (II) ION, GLYCEROL, ...
Authors:Drennan, C.L, Dey, M.
Deposit date:2013-02-03
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.
Nature, 496, 2013

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