1C8P
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![BU of 1c8p by Molmil](/molmil-images/mine/1c8p) | NMR STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE COMMON BETA-CHAIN IN THE GM-CSF, IL-3 AND IL-5 RECEPTORS | Descriptor: | CYTOKINE RECEPTOR COMMON BETA CHAIN | Authors: | Mulhern, T.D, D'Andrea, R.J, Gaunt, C, Vandeleur, L, Vadas, M.A, Lopez, A.F, Booker, G.W, Bagley, C.J. | Deposit date: | 1999-10-05 | Release date: | 2000-06-15 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. J.Mol.Biol., 297, 2000
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7Z5X
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![BU of 7z5x by Molmil](/molmil-images/mine/7z5x) | ROS1 with AstraZeneca ligand 2 | Descriptor: | (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol, Proto-oncogene tyrosine-protein kinase ROS | Authors: | Hargreaves, D. | Deposit date: | 2022-03-10 | Release date: | 2022-08-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.035 Å) | Cite: | Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors. J.Chem.Inf.Model., 62, 2022
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7Z5W
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![BU of 7z5w by Molmil](/molmil-images/mine/7z5w) | ROS1 with AstraZeneca ligand 1 | Descriptor: | Proto-oncogene tyrosine-protein kinase ROS, SULFATE ION, ~{N}-[6-methyl-2-[(2~{S})-2-[3-(3-methylpyrazin-2-yl)-1,2-oxazol-5-yl]pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine | Authors: | Hargreaves, D. | Deposit date: | 2022-03-10 | Release date: | 2022-08-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.254 Å) | Cite: | Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors. J.Chem.Inf.Model., 62, 2022
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4Q30
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![BU of 4q30 by Molmil](/molmil-images/mine/4q30) | Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 | Descriptor: | 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2 CHIMERIC PROTEIN, ZINC ION | Authors: | Ahmed, A.H, Oswald, R.E. | Deposit date: | 2014-04-10 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development. Biochemistry, 53, 2014
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5C8T
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![BU of 5c8t by Molmil](/molmil-images/mine/5c8t) | Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM | Descriptor: | Guanine-N7 methyltransferase, MAGNESIUM ION, Non-structural protein 10, ... | Authors: | Ma, Y.Y, Wu, L.J, Zhang, R.G, Rao, Z.H. | Deposit date: | 2015-06-26 | Release date: | 2015-07-15 | Last modified: | 2015-08-12 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex Proc.Natl.Acad.Sci.USA, 112, 2015
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2MRE
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![BU of 2mre by Molmil](/molmil-images/mine/2mre) | NMR structure of the Rad18-UBZ/ubiquitin complex | Descriptor: | E3 ubiquitin-protein ligase RAD18, Polyubiquitin-C, ZINC ION | Authors: | Rizzo, A.A, Salerno, P.E, Bezsonova, I, Korzhnev, D.M. | Deposit date: | 2014-07-03 | Release date: | 2014-10-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR Structure of the Human Rad18 Zinc Finger in Complex with Ubiquitin Defines a Class of UBZ Domains in Proteins Linked to the DNA Damage Response. Biochemistry, 53, 2014
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4OCF
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![BU of 4ocf by Molmil](/molmil-images/mine/4ocf) | |
6IF0
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![BU of 6if0 by Molmil](/molmil-images/mine/6if0) | Crystal structure of CERT START domain in complex with compound D16 | Descriptor: | 2-({4'-pentyl-3'-[(Z)-2-(pyridin-2-yl)ethenyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol, LIPID-TRANSFER PROTEIN CERT | Authors: | Suzuki, M, Nakao, N, Ueno, M, Sakai, S, Egawa, D, Hanzawa, H, Kawasaki, S, Kumagai, K, Kobayashi, S, Hanada, K. | Deposit date: | 2018-09-18 | Release date: | 2019-02-27 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT Commun Chem, 2019
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2JNH
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![BU of 2jnh by Molmil](/molmil-images/mine/2jnh) | Solution Structure of the UBA Domain from Cbl-b | Descriptor: | E3 ubiquitin-protein ligase CBL-B | Authors: | Zhou, C, Zhou, Z, Lin, D, Hu, H. | Deposit date: | 2007-01-24 | Release date: | 2008-02-05 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights Protein Sci., 17, 2008
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5M4Q
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![BU of 5m4q by Molmil](/molmil-images/mine/5m4q) | Crystal Structure of Wild-Type Human Prolidase with Mn ions and Pro ligand | Descriptor: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | Authors: | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | Deposit date: | 2016-10-18 | Release date: | 2017-07-12 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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6VLB
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![BU of 6vlb by Molmil](/molmil-images/mine/6vlb) | |
3PCU
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![BU of 3pcu by Molmil](/molmil-images/mine/3pcu) | Crystal structure of human retinoic X receptor alpha ligand-binding domain complexed with LX0278 and SRC1 peptide | Descriptor: | 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | Authors: | Zhang, H, Zhang, Y, Shen, H, Chen, J, Li, C, Chen, L, Hu, L, Jiang, H, Shen, X. | Deposit date: | 2010-10-22 | Release date: | 2011-11-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice. Plos One, 7, 2012
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3ME2
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![BU of 3me2 by Molmil](/molmil-images/mine/3me2) | Crystal structure of mouse RANKL-RANK complex | Descriptor: | CHLORIDE ION, SODIUM ION, Tumor necrosis factor ligand superfamily member 11, ... | Authors: | Walter, S.W, Liu, C.Z, Zhu, X.K, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J. | Deposit date: | 2010-03-31 | Release date: | 2010-06-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and Functional Insights of RANKL-RANK Interaction and Signaling. J.Immunol., 2010
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3V3L
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![BU of 3v3l by Molmil](/molmil-images/mine/3v3l) | Crystal structure of human RNF146 WWE domain in complex with iso-ADPRibose | Descriptor: | 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), E3 ubiquitin-protein ligase RNF146 | Authors: | Wang, Z, Cheng, Z, Xu, W. | Deposit date: | 2011-12-13 | Release date: | 2012-02-15 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Genes Dev., 26, 2012
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7EC1
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![BU of 7ec1 by Molmil](/molmil-images/mine/7ec1) | Crystal structure of SdgB (ligand-free form) | Descriptor: | GLYCEROL, Glycosyl transferase, group 1 family protein, ... | Authors: | Kim, D.-G, Baek, I, Lee, Y, Kim, H.S. | Deposit date: | 2021-03-11 | Release date: | 2021-03-24 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins. Acta Crystallogr D Struct Biol, 77, 2021
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2GFE
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7OOE
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![BU of 7ooe by Molmil](/molmil-images/mine/7ooe) | Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z321318226 | Descriptor: | AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ... | Authors: | Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. | Deposit date: | 2021-05-27 | Release date: | 2021-06-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.369 Å) | Cite: | Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands To Be Published
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8IEG
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![BU of 8ieg by Molmil](/molmil-images/mine/8ieg) | Bre1(mRBD-RING)/Rad6-Ub/nucleosome complex | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase BRE1, Histone H2A type 1-B/E, ... | Authors: | Ai, H, Deng, Z, Pan, M, Liu, L. | Deposit date: | 2023-02-15 | Release date: | 2023-09-06 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Mol.Cell, 83, 2023
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1TF1
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![BU of 1tf1 by Molmil](/molmil-images/mine/1tf1) | Crystal Structure of the E. coli Glyoxylate Regulatory Protein Ligand Binding Domain | Descriptor: | Negative regulator of allantoin and glyoxylate utilization operons | Authors: | Walker, J.R, Skarina, T, Kudrytska, M, Joachimiak, A, Arrowsmith, C, Edwards, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2004-05-26 | Release date: | 2004-08-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and biochemical study of effector molecule recognition by the E.coli glyoxylate and allantoin utilization regulatory protein AllR. J.Mol.Biol., 358, 2006
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5M4L
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![BU of 5m4l by Molmil](/molmil-images/mine/5m4l) | Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand | Descriptor: | GLYCEROL, HYDROXIDE ION, LEUCINE, ... | Authors: | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | Deposit date: | 2016-10-18 | Release date: | 2017-07-12 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Substrate specificity and reaction mechanism of human prolidase. FEBS J., 284, 2017
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3RGS
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![BU of 3rgs by Molmil](/molmil-images/mine/3rgs) | |
4OD7
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![BU of 4od7 by Molmil](/molmil-images/mine/4od7) | |
5L19
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![BU of 5l19 by Molmil](/molmil-images/mine/5l19) | Crystal Structure of a human FasL mutant | Descriptor: | SULFATE ION, Tumor necrosis factor ligand superfamily member 6, ZINC ION | Authors: | Liu, W, Bonanno, J.B, Almo, S.C. | Deposit date: | 2016-07-28 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure, 24, 2016
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4AM1
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![BU of 4am1 by Molmil](/molmil-images/mine/4am1) | Crystal structure of the marine crustacean decapod shrimp (Litopenaeus vannamei) arginine kinase in the absence of substrate or ligands. | Descriptor: | ARGININE KINASE | Authors: | Lopez-Zavala, A.A, Sotelo-Mundo, R.R, Garcia-Orozco, K.D, Isac-Martinez, F, Brieba, L.G, Rudino-Pinera, E. | Deposit date: | 2012-03-07 | Release date: | 2012-07-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Crystallization and X-Ray Diffraction Studies of Arginine Kinase from the White Pacific Shrimp Litopenaeus Vannamei. Acta Crystallogr.,Sect.F, 68, 2012
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2LAZ
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![BU of 2laz by Molmil](/molmil-images/mine/2laz) | Structure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide | Descriptor: | E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1 | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | Deposit date: | 2011-03-22 | Release date: | 2011-07-06 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev., 25, 2011
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