7WH5
| Crystal structure of human ClpP in complex with ZG180 | Descriptor: | (6S,9aS)-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | Authors: | Wei, B.Y, Gan, J.H, Yang, C.-G. | Deposit date: | 2021-12-29 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nat Commun, 13, 2022
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7WGS
| Structure of ClpP from Staphylococcus aureus in complex with (S)-ZG197 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6S,9aS)-6-[(2R)-butan-2-yl]-8-[(1S)-1-naphthalen-1-ylethyl]-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit | Authors: | Yang, C.-G, Gan, J.H. | Deposit date: | 2021-12-28 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nat Commun, 13, 2022
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6POD
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PO3
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PPE
| ClpP and ClpX IGF loop in ClpX-ClpP complex with D7 symmetry | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-06 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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8E91
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8E8Q
| Cryo-EM structure of substrate-free DNClpX.ClpP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ghanbarpour, A, Cohen, S, Davis, J.H, Sauer, R.T. | Deposit date: | 2022-08-25 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structure of substrate-free DNClpX.ClpP Nat Commun, 2023
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8E7V
| Cryo-EM structure of substrate-free DNClpX.ClpP from singly capped particles | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ghanbarpour, A, Cohen, S, Davis, J.H, Sauer, R.T. | Deposit date: | 2022-08-24 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of substrate-free DNClpX.ClpP Nat Commun, 2023
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6POS
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PO1
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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8ET3
| Cryo-EM structure of a delivery complex containing the SspB adaptor, an ssrA-tagged substrate, and the AAA+ ClpXP protease | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Ghanbarpour, A, Fei, X, Davis, J.H, Sauer, R.T. | Deposit date: | 2022-10-16 | Release date: | 2023-01-25 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery. Proc.Natl.Acad.Sci.USA, 120, 2023
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6VFX
| ClpXP from Neisseria meningitidis - Conformation B | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-06 | Release date: | 2020-01-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. Elife, 9, 2020
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6VFS
| ClpXP from Neisseria meningitidis - Conformation A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-06 | Release date: | 2020-01-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. Elife, 9, 2020
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6WR2
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6WRF
| ClpX-ClpP complex bound to GFP-ssrA, recognition complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Sauer, R.T. | Deposit date: | 2020-04-29 | Release date: | 2020-11-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Elife, 9, 2020
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6WSG
| ClpX-ClpP complex bound to ssrA-tagged GFP, intermediate complex | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, Green fluorescent protein, ... | Authors: | Fei, X, Sauer, R.T. | Deposit date: | 2020-04-30 | Release date: | 2020-11-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Elife, 9, 2020
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6UQE
| ClpA/ClpP Disengaged State bound to RepA-GFP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Lopez, K.L, Rizo, A.R, Southworth, D.R. | Deposit date: | 2019-10-18 | Release date: | 2020-04-22 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
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8XON
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8XOO
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7EKQ
| CrClpP-S2c | Descriptor: | ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Wang, N, Wang, Y.F, Cong, Y, Liu, C.M. | Deposit date: | 2021-04-06 | Release date: | 2021-10-20 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The cryo-EM structure of the chloroplast ClpP complex. Nat.Plants, 7, 2021
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6UQO
| ClpA/ClpP Engaged State bound to RepA-GFP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp endopeptidase proteolytic subunit ClpP, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | Authors: | Lopez, K.L, Rizo, A.N, Southworth, D.R. | Deposit date: | 2019-10-21 | Release date: | 2020-04-22 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
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6W20
| ClpAP Disengaged State bound to RepA-GFP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | Authors: | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | Deposit date: | 2020-03-04 | Release date: | 2020-05-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
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6W1Z
| ClpAP Engaged1 State bound to RepA-GFP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | Authors: | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | Deposit date: | 2020-03-04 | Release date: | 2020-05-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
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6W21
| ClpAP Engaged2 State bound to RepA-GFP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | Authors: | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | Deposit date: | 2020-03-04 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
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7UIW
| ClpAP complex bound to ClpS N-terminal extension, class IIb | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease adapter protein ClpS, ... | Authors: | Kim, S, Fei, X, Sauer, R.T, Baker, T.A. | Deposit date: | 2022-03-29 | Release date: | 2022-11-09 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | AAA+ protease-adaptor structures reveal altered conformations and ring specialization. Nat.Struct.Mol.Biol., 29, 2022
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