7WGS

Structure of ClpP from Staphylococcus aureus in complex with (S)-ZG197

Summary for 7WGS

• Entry DOI: 10.2210/pdb7wgs/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, (6S,9aS)-6-[(2R)-butan-2-yl]-8-[(1S)-1-naphthalen-1-ylethyl]-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• Functional Keywords: clpp, staphyloccocus aureus, activator, hydrolase
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 14
• Total formula weight: 310740.42

Authors

Yang, C.-G.,Gan, J.H. (deposition date: 2021-12-28, release date: 2022-11-16, Last modification date: 2023-11-29)

• Primary citation: Wei, B.,Zhang, T.,Wang, P.,Pan, Y.,Li, J.,Chen, W.,Zhang, M.,Ji, Q.,Wu, W.,Lan, L.,Gan, J.,Yang, C.G.; Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.; Nat Commun, 13:6909-6909, 2022; PubMed: 36376309; DOI: 10.1038/s41467-022-34753-0

Experimental method

X-RAY DIFFRACTION (2.11 Å)