7WH5

Crystal structure of human ClpP in complex with ZG180

Summary for 7WH5

• Entry DOI: 10.2210/pdb7wh5/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, (6S,9aS)-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: protease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 14
• Total formula weight: 345943.07

Authors

Wei, B.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2021-12-29, release date: 2022-11-16, Last modification date: 2023-11-29)

• Primary citation: Wei, B.,Zhang, T.,Wang, P.,Pan, Y.,Li, J.,Chen, W.,Zhang, M.,Ji, Q.,Wu, W.,Lan, L.,Gan, J.,Yang, C.G.; Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.; Nat Commun, 13:6909-6909, 2022; PubMed: 36376309; DOI: 10.1038/s41467-022-34753-0

Experimental method

X-RAY DIFFRACTION (2.13 Å)