PDB: 234 resultsInfo pagesStatus searchChemie searchBIRD

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5V9F	Structure of the H477R variant of rat cytosolic PEPCK in complex with beta sulfopyruvate and GTP. Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Holyoak, T, Cui, D.S. Deposit date: 2017-03-23 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5FH0	The structure of rat cytosolic PEPCK variant E89A complex with GTP Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH4	The structure of rat cytosolic PEPCK variant E89D in complex with beta-sulfopyruvate and GTP Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5V97	Structure of the H477R variant of rat cytosolic PEPCK in complex with GTP. Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Holyoak, T, Cui, D.S. Deposit date: 2017-03-23 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5V95	Structure of the H477R variant of rat cytosolic PEPCK in complex with manganese. Descriptor: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... Authors: Holyoak, T, Cui, D.S. Deposit date: 2017-03-23 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5FH1	The structure of rat cytosolic PEPCK variant E89D in complex with GTP Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2015-12-21 Release date: 2016-12-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5V9H	Structure of the H477R variant of rat cytosolic PEPCK in complex with phosphoglycolate and GDP. Descriptor: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Holyoak, T, Cui, D.S. Deposit date: 2017-03-23 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
4GMZ	Structure of rat cytosolic PEPCK Ld_2g in complex with Beta-Sulfopyruvate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNM	Structure of rat cytosolic PEPCK Ld_2g in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNL	Structure of rat cytosolic PEPCK Ld_2g in complex with PEP and GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMM	Structure of rat cytosolic PEPCK Ld_1g in complex with Beta-Sulfopyruvate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.736 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMW	Structure of rat cytosolic PEPCK Ld_1g in complex with PEP and GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMU	Structure of rat cytosolic PEPCK Ld_1g in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNQ	Structure of rat cytosolic PEPCK Ld_3g in complex with oxalate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNP	Structure of rat cytosolic PEPCK Ld_3g in complex with PEP and GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.744 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GNO	Structure of rat cytosolic PEPCK Ld_3g in complex with Beta-Sulfopyruvate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-17 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
3BLR	Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol Descriptor: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ... Authors: Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. Deposit date: 2007-12-11 Release date: 2008-07-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
8K5R	CDK9/cyclin T1 in complex with KB-0742 Descriptor: (1S,3S)-N3-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine, Cyclin-T1, Cyclin-dependent kinase 9 Authors: Zhou, M, Li, H, Gao, H, Trotter, B.W, Freeman, D. Deposit date: 2023-07-24 Release date: 2023-12-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.751 Å) Cite: Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J.Med.Chem., 66, 2023
1BY4	STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA Descriptor: DNA (5'-D(*C*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*A)-3'), PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA), ... Authors: Zhao, Q, Chasse, S.A, Devarakonda, S, Sierk, M.L, Ahvazi, B, Sigler, P.B, Rastinejad, F. Deposit date: 1998-10-22 Release date: 2000-01-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis of RXR-DNA interactions. J.Mol.Biol., 296, 2000
1YNW	Crystal Structure of Vitamin D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element Descriptor: 5'-d(*TP*TP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*AP*A)-3', 5'-d(*TP*TP*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*A)-3', Retinoic acid receptor RXR-alpha, ... Authors: Shaffer, P.L, Gewirth, D.T. Deposit date: 2005-01-25 Release date: 2005-02-15 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analysis of RXR-VDR interactions on DR3 DNA J.Steroid Biochem.Mol.Biol., 89-90, 2004
7QGS	Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) Descriptor: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION Authors: Hegedus, Z, Wilson, A.J, Edwards, T.A. Deposit date: 2021-12-10 Release date: 2022-05-11 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Understanding p300-transcription factor interactions using sequence variation and hybridization. Rsc Chem Biol, 3, 2022
7NWK	Crystal structure of CDK9-Cyclin T1 bound by compound 6 Descriptor: Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide Authors: Collie, G.W, Ferguson, A.D. Deposit date: 2021-03-16 Release date: 2021-10-27 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J.Med.Chem., 64, 2021
7CD5	mAPE1-blunt-ended dsDNA product complex Descriptor: DNA(5'-D(*CP*GP*TP*AP*AP*TP*AP*CP*G)-3'), DNA-(apurinic or apyrimidinic site) endonuclease Authors: Liu, T.C, Hsiao, Y.Y. Deposit date: 2020-06-18 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling. Nat Commun, 12, 2021
6MCF	Solution structure of 7SK stem-loop 1 with HIV-1 Tat RNA Binding Domain Descriptor: 7SK Stem-loop 1 RNA, Protein Tat Authors: Pham, V.V, D'Souza, V.M. Deposit date: 2018-08-31 Release date: 2018-10-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry. Nat Commun, 9, 2018
6MCE	Solution structure of HIV-1 TAR with Tat RNA Binding Domain Descriptor: Protein Tat, TAR RNA Authors: Pham, V.V, D'Souza, V.M. Deposit date: 2018-08-31 Release date: 2018-10-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry. Nat Commun, 9, 2018

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