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6HLQ	Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-11 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
5LMX	Monomeric RNA polymerase I at 4.9 A resolution Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Torreira, E, Louro, J.A, Gil-Carton, D, Gallego, O, Calvo, O, Fernandez-Tornero, C. Deposit date: 2016-08-02 Release date: 2017-03-22 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription. Elife, 6, 2017
6HTQ	Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Wilson, D.N, Abdelshahid, M. Deposit date: 2018-10-04 Release date: 2019-10-23 Last modified: 2020-09-30 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel. Cell Rep, 32, 2020
5ENF	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with fragment-4 N10142 (SGC - Diamond I04-1 fragment screening) Descriptor: 1,2-ETHANEDIOL, 5-azanyl-2-(2-methylpropyl)-1,3-oxazole-4-carbonitrile, PH-interacting protein Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Amin, J, Szykowska, A, Burgess-Brown, N, Spencer, J, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.37 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
6HLR	Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused) Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-11 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
5ENH	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-12 N11528 (SGC - Diamond I04-1 fragment screening) Descriptor: PH-interacting protein, ~{N}-[(2,6-dimethoxyphenyl)methyl]ethanamide Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Szykowska, A, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
6IPB	Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15 Descriptor: GLYCEROL, L(+)-TARTARIC ACID, UDP-glucuronosyltransferase 2B15 Authors: Zhang, L, Xie, W, Wang, C. Deposit date: 2018-11-02 Release date: 2020-01-15 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem. Pharmacol., 172, 2019
5ENB	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening) Descriptor: 1,2-ETHANEDIOL, 1-(2-methylphenyl)thiourea, PH-interacting protein Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Szykowska, A, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.73 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
5ENI	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-13 N11537 (SGC - Diamond I04-1 fragment screening) Descriptor: PH-interacting protein, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]-2-oxidanyl-ethanamide Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Szykowska, A, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.69 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
5ENJ	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-14 N11530 (SGC - Diamond I04-1 fragment screening) Descriptor: MAGNESIUM ION, PH-interacting protein, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]-~{N}-methyl-ethanamide Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Szykowska, A, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.63 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
6HKO	Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-07 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.42 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
7K17	Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix Descriptor: DNA-dependent protein kinase catalytic subunit, X-ray repair cross-complementing protein 5 Authors: Chen, X, Gellert, M, Yang, W. Deposit date: 2020-09-07 Release date: 2021-01-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (4.3 Å) Cite: Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
5ENE	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with 5-Amino-2-benzyl-1,3-oxazole-4-carbonitrile (SGC - Diamond I04-1 fragment screening) Descriptor: 5-azanyl-2-(phenylmethyl)-1,3-oxazole-4-carbonitrile, PH-interacting protein Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Amin, J, Szykowska, A, Burgess-Brown, N, Spencer, J, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.49 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
6HLS	Yeast apo RNA polymerase I* Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Tafur, L, Sadian, Y, Weis, F, Muller, C.W. Deposit date: 2018-09-11 Release date: 2019-04-03 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
7YAN	UDP-glucuronosyltransferase2B17 C-terminal domain Descriptor: L(+)-TARTARIC ACID, UDP-glucuronosyltransferase 2B17 Authors: Wang, C.Y, Zhang, L. Deposit date: 2022-06-28 Release date: 2023-07-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: UDP-glucuronosyltransferase2B17 C-terminal domain To Be Published
7YF5	Crystal Structure of the UDPGA Binding Domain of the Human Phase II Metabolizing Enzyme UDP-Glucuronosyltransferase 2B10 Descriptor: SULFATE ION, UDP-glucuronosyltransferase 2B10 Authors: Yin, X.L, Tong, J.S. Deposit date: 2022-07-07 Release date: 2023-07-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.527 Å) Cite: Crystal Structure Determination of Nucleotide-sugar Binding Domain of Human UDP-glucuronosyltransferases 2B10. Protein Pept.Lett., 30, 2023
5ENC	Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with N-(2,6-Dichlorobenzyl)acetamide (SGC - Diamond I04-1 fragment screening) Descriptor: 1,2-ETHANEDIOL, PH-interacting protein, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]ethanamide Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Szykowska, A, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016
5M3F	Yeast RNA polymerase I elongation complex at 3.8A Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S. Deposit date: 2016-10-14 Release date: 2016-11-23 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structure of RNA polymerase I transcribing ribosomal DNA genes. Nature, 540, 2016
5M3M	Free monomeric RNA polymerase I at 4.0A resolution Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S. Deposit date: 2016-10-15 Release date: 2016-11-23 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structure of RNA polymerase I transcribing ribosomal DNA genes. Nature, 540, 2016
8QCQ	B. subtilis ApdA-stalled ribosomal complex Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Morici, M, Wilson, D.N. Deposit date: 2023-08-28 Release date: 2024-03-20 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity. Nat Commun, 15, 2024
6RNX	Crystal structure of the essential repressor DdrO from radiation-resistant Deinococcus bacteria (Deinococcus deserti) Descriptor: CHLORIDE ION, HTH-type transcriptional regulator DdrOC Authors: Arnoux, P, Siponen, M.I, Pignol, D, De Groot, A, Blanchard, L. Deposit date: 2019-05-09 Release date: 2019-10-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
6RQT	RNA Polymerase I-tWH-Rrn3-DNA Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Mueller, C.W, Sadian, Y, Tafur, L. Deposit date: 2019-05-16 Release date: 2019-12-11 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4 Å) Cite: Molecular insight into RNA polymerase I promoter recognition and promoter melting. Nat Commun, 10, 2019
6RUI	RNA Polymerase I Pre-initiation complex DNA opening intermediate 2 Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... Authors: Mueller, C.W, Sadian, Y, Tafur, L. Deposit date: 2019-05-28 Release date: 2019-12-11 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Molecular insight into RNA polymerase I promoter recognition and promoter melting. Nat Commun, 10, 2019
8QPP	Bacillus subtilis MutS2-collided disome complex (stalled 70S) Descriptor: 16S rRNA (1533-MER), 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Park, E, Mackens-Kiani, T, Berhane, R, Esser, H, Erdenebat, C, Burroughs, A.M, Berninghausen, O, Aravind, L, Beckmann, R, Green, R, Buskirk, A.R. Deposit date: 2023-10-02 Release date: 2023-12-27 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage. Embo J., 43, 2024
8R55	Bacillus subtilis MutS2-collided disome complex (collided 70S) Descriptor: 16S rRNA (1533-MER), 23S RNA (2887-MER), 30S ribosomal protein S10, ... Authors: Park, E, Mackens-Kiani, T, Berhane, R, Esser, H, Erdenebat, C, Burroughs, A.M, Berninghausen, O, Aravind, L, Beckmann, R, Green, R, Buskirk, A.R. Deposit date: 2023-11-16 Release date: 2024-01-17 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage. Embo J., 43, 2024

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