5X2S
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8BHA
| GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Basmisanil, Gamma-aminobutyric acid receptor subunit alpha-5 | Authors: | Malinauskas, T.M, Wahid, A.A, Hardwick, S.W, Chirgadze, D.Y, Miller, P.S. | Deposit date: | 2022-10-30 | Release date: | 2023-11-01 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
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8BHR
| GABA-A receptor a5 homomer - a5V3 - RO7015738 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{N}-[(2~{S})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide, Gamma-aminobutyric acid receptor subunit alpha-5 | Authors: | Miller, P.S, Malinauskas, T.M, Kasaragod, V.B. | Deposit date: | 2022-10-31 | Release date: | 2023-11-01 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
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5X3X
| 2.8A resolution structure of a cobalt energy-coupling factor transporter-CbiMQO | Descriptor: | Cobalt ABC transporter ATP-binding protein, Cobalt transport protein CbiM, Uncharacterized protein CbiQ | Authors: | Bao, Z, Qi, X, Wang, J, Zhang, P. | Deposit date: | 2017-02-09 | Release date: | 2017-04-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.788 Å) | Cite: | Structure and mechanism of a group-I cobalt energy coupling factor transporter Cell Res., 27, 2017
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6OB6
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6OB7
| Human equilibrative nucleoside transporter-1, dilazep bound | Descriptor: | (1,4-diazepane-1,4-diyl)di(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate), (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Equilibrative nucleoside transporter 1 | Authors: | Wright, N.J, Lee, S.-Y. | Deposit date: | 2019-03-19 | Release date: | 2019-07-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of human ENT1 in complex with adenosine reuptake inhibitors. Nat.Struct.Mol.Biol., 26, 2019
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6OEV
| Structure of human Patched1 in complex with native Sonic Hedgehog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1, ... | Authors: | Qi, X, Li, X. | Deposit date: | 2019-03-27 | Release date: | 2019-04-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
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8BL0
| Human Sirt6 in complex with the inhibitor S6023 and ADP-ribose | Descriptor: | 3-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonylbenzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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6OGG
| 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV). | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Svidritskiy, E, Demo, G, Loveland, A.B, Xu, C, Korostelev, A.A. | Deposit date: | 2019-04-02 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Extensive ribosome and RF2 rearrangements during translation termination. Elife, 8, 2019
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8BL1
| Human Sirt6 in complex with the inhibitor S6039 and ADP-ribose | Descriptor: | 2-azanyl-5-[4-[[5-(2-fluorophenyl)thiophen-2-yl]methyl]piperazin-1-yl]sulfonyl-benzenesulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2022-11-09 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
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8BM3
| H207A mutant of E. coli PgpB, a PAP2 type phosphatidyl glycerol phosphate and C55-PP phosphatase, in complex with farnesyl pyrophosphate | Descriptor: | FARNESYL DIPHOSPHATE, Phosphatidylglycerophosphatase B | Authors: | Delbrassine, F, El Ghachi, M, Lambion, A, Herman, R, Kerff, F. | Deposit date: | 2022-11-10 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | H207A mutant of E. coli PgpB, a PAP2 type phosphatidyl glycerol phosphate and C55-PP phosphatase, in complex with farnesyl pyrophosphate To Be Published
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6O7I
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6O7V
| Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 1 | Descriptor: | Putative protein YPR170W-B, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | Deposit date: | 2019-03-08 | Release date: | 2019-04-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6OOM
| PROTEIN A | Descriptor: | LAURYL DIMETHYLAMINE-N-OXIDE, Multidrug transporter MdfA, PRASEODYMIUM ION | Authors: | Lu, M. | Deposit date: | 2019-04-23 | Release date: | 2019-09-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition. Commun Biol, 2, 2019
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8BS4
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8BS6
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5F5J
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5XH3
| Crystal structure of a novel PET hydrolase R103G/S131A mutant in complex with HEMT from Ideonella sakaiensis 201-F6 | Descriptor: | GLYCEROL, O 4-(2-hydroxyethyl) O 1-methyl benzene-1,4-dicarboxylate, Poly(ethylene terephthalate) hydrolase, ... | Authors: | Han, X, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | Deposit date: | 2017-04-19 | Release date: | 2017-12-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural insight into catalytic mechanism of PET hydrolase Nat Commun, 8, 2017
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5X79
| Human GST Pi conjugated with novel inhibitor, GS-ESF | Descriptor: | (2S)-2-azanyl-5-[[(2R)-3-(2-fluorosulfonylethylsulfanyl)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glutathione S-transferase P | Authors: | Tomoike, F, Shishido, Y, Fukui, K, Kimura, Y, Abe, H. | Deposit date: | 2017-02-24 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1). Chem. Commun. (Camb.), 53, 2017
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8BS5
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6OEP
| Cryo-EM structure of mouse RAG1/2 12RSS-NFC/23RSS-PRC complex (DNA1) | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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8BY1
| streptavidin with an iridium catalyst for CH activation | Descriptor: | SULFATE ION, Streptavidin, tert-butyl 7'-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-1-chloranyl-2,3,4,5,6-pentamethyl-spiro[1$l^{8}-iridapentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane-1,2'-3-aza-1-azonia-2$l^{8}-iridatricyclo[6.3.1.0^{4,12}]dodeca-1(11),4,6,8(12),9-pentaene]-3'-carboxylate | Authors: | Igareta, N.V, Ward, T.R. | Deposit date: | 2022-12-11 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.486 Å) | Cite: | streptavidin mutant S112I with an iridium catalyst for CH activation To Be Published
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8BY0
| streptavidin mutant S112I K121R with an iridium catalyst for CH activation | Descriptor: | SULFATE ION, Streptavidin, tert-butyl 7'-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-1-chloranyl-2,3,4,5,6-pentamethyl-spiro[1$l^{8}-iridapentacyclo[2.2.0.0^{1,3}.0^{1,5}.0^{2,6}]hexane-1,2'-3-aza-1-azonia-2$l^{8}-iridatricyclo[6.3.1.0^{4,12}]dodeca-1(11),4,6,8(12),9-pentaene]-3'-carboxylate | Authors: | Igareta, N.V, Ward, T.R. | Deposit date: | 2022-12-11 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | streptavidin mutant S112I with an iridium catalyst for CH activation To Be Published
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6OH3
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6OSK
| RF1 accommodated 70S complex at 60 ms | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Fu, Z, Indrisiunaite, G, Kaledhonkar, S, Shah, B, Sun, M, Chen, B, Grassucci, R.A, Ehrenberg, M, Frank, J. | Deposit date: | 2019-05-01 | Release date: | 2019-06-26 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Nat Commun, 10, 2019
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