5ZDR
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![BU of 5zdr by Molmil](/molmil-images/mine/5zdr) | Crystal structure of cyanide-insensitive alternative oxidase from Trypanosoma brucei with ascofuranone derivative | Descriptor: | 3-chloro-4,6-dihydroxy-5-[(2E,6E,8S)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde, Alternative oxidase, mitochondrial, ... | Authors: | Shiba, T, Inaoka, D.K, Takahashi, G, Tsuge, C, Kido, Y, Young, L, Ueda, S, Balogun, E.O, Nara, T, Honma, T, Tanaka, A, Inoue, M, Saimoto, H, Harada, S, Moore, A.L, Kita, K. | Deposit date: | 2018-02-23 | Release date: | 2019-02-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. Biochim Biophys Acta Bioenerg, 1860, 2019
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3ICO
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3HVH
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![BU of 3hvh by Molmil](/molmil-images/mine/3hvh) | Rat catechol O-methyltransferase in complex with a catechol-type, N6-methyladenine-containing bisubstrate inhibitor | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, CHLORIDE ION, Catechol O-methyltransferase, ... | Authors: | Ehler, A, Schlatter, D, Stihle, M, Benz, J, Rudolph, M.G. | Deposit date: | 2009-06-16 | Release date: | 2009-10-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor. Angew.Chem.Int.Ed.Engl., 48, 2009
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7Y6Y
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![BU of 7y6y by Molmil](/molmil-images/mine/7y6y) | RLGSGG-AtPRT6 UBR box (C121) | Descriptor: | E3 ubiquitin-protein ligase PRT6, ZINC ION | Authors: | Kim, L, Song, H.K. | Deposit date: | 2022-06-21 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.543 Å) | Cite: | Structural analyses of plant PRT6-UBR box for Cys-Arg/N-degron pathway and insights into the plant submergence resistance To Be Published
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3HWG
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7Y6X
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![BU of 7y6x by Molmil](/molmil-images/mine/7y6x) | RRGSGG-AtPRT6 UBR box (P32) | Descriptor: | E3 ubiquitin-protein ligase PRT6, ZINC ION | Authors: | Kim, L, Song, H.K. | Deposit date: | 2022-06-21 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.196 Å) | Cite: | Structural analyses of plant PRT6-UBR box for Cys-Arg/N-degron pathway and insights into the plant submergence resistance To Be Published
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2W8C
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3HND
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![BU of 3hnd by Molmil](/molmil-images/mine/3hnd) | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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7YJ1
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![BU of 7yj1 by Molmil](/molmil-images/mine/7yj1) | Cryo-EM structure of SPT-ORMDL3 (ORMDL3-deltaN2) complex | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-19 | Release date: | 2023-07-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 14, 2023
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3HRC
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4XTL
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![BU of 4xtl by Molmil](/molmil-images/mine/4xtl) | Crystal structure of the light-driven sodium pump KR2 in the monomeric blue form, pH 4.3 | Descriptor: | EICOSANE, GLYCEROL, SODIUM ION, ... | Authors: | Gushchin, I, Shevchenko, V, Polovinkin, V, Gordeliy, V. | Deposit date: | 2015-01-23 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of a light-driven sodium pump. Nat.Struct.Mol.Biol., 22, 2015
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4ZBF
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![BU of 4zbf by Molmil](/molmil-images/mine/4zbf) | Mcl-1 complexed with small molecules | Descriptor: | (1R)-7-[3-(naphthalen-1-yloxy)propyl]-3,4-dihydro-2H-[1,4]thiazepino[2,3,4-hi]indole-6-carboxylic acid 1-oxide, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Zhao, B. | Deposit date: | 2015-04-14 | Release date: | 2015-04-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. J.Med.Chem., 58, 2015
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4ZD3
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![BU of 4zd3 by Molmil](/molmil-images/mine/4zd3) | Structure of a transglutaminase 2-specific autoantibody Fab fragment | Descriptor: | 679-14-14E06 Fab fragment heavy chain, 679-14-14E06 Fab fragment light chain | Authors: | Chen, X, Dalhus, B, Hnida, K, Iversen, R, Sollid, L.M. | Deposit date: | 2015-04-16 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease. J.Biol.Chem., 290, 2015
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7YIU
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![BU of 7yiu by Molmil](/molmil-images/mine/7yiu) | Cryo-EM structure of the C6-ceramide-bound SPT-ORMDL3 complex | Descriptor: | HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)HEXANAMIDE, ORM1-like protein 3, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-18 | Release date: | 2023-07-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 14, 2023
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7YJ2
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![BU of 7yj2 by Molmil](/molmil-images/mine/7yj2) | Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | Authors: | Xie, T, Liu, P, Gong, X. | Deposit date: | 2022-07-19 | Release date: | 2023-07-05 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 14, 2023
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4Z07
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![BU of 4z07 by Molmil](/molmil-images/mine/4z07) | Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Kim, J.J, Reger, A.S, Arold, S.T, Kim, C. | Deposit date: | 2015-03-25 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure, 24, 2016
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3I0A
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2W47
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![BU of 2w47 by Molmil](/molmil-images/mine/2w47) | Clostridium thermocellum CBM35 in complex with delta-4,5- anhydrogalacturonic acid | Descriptor: | 4-deoxy-beta-L-threo-hex-4-enopyranuronic acid-(1-4)-beta-D-galactopyranuronic acid, CALCIUM ION, LIPOLYTIC ENZYME, ... | Authors: | Montainer, C, Lammerts van Bueren, A, Dumon, C, Flint, J.E, Correia, M.A, Prates, J.A, Firbank, S.J, Lewis, R.J, Grondin, G.G, Ghinet, M.G, Gloster, T.M, Herve, C, Knox, J.P, Talbot, B.G, Turkenburg, J.P, Kerovuo, J, Brzezinski, R, Fontes, C.M.G.A, Davies, G.J, Boraston, A.B, Gilbert, H.J. | Deposit date: | 2008-11-21 | Release date: | 2009-01-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Evidence that Family 35 Carbohydrate Binding Modules Display Conserved Specificity But Divergent Function. Proc.Natl.Acad.Sci.USA, 106, 2009
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4Z7V
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![BU of 4z7v by Molmil](/molmil-images/mine/4z7v) | L3-12 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ... | Authors: | Petersen, J, Rossjohn, J, Reid, H.H, Koning, F. | Deposit date: | 2015-04-08 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Determinants of Gliadin-Specific T Cell Selection in Celiac Disease. J Immunol., 194, 2015
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3HNF
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![BU of 3hnf by Molmil](/molmil-images/mine/3hnf) | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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4YYZ
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![BU of 4yyz by Molmil](/molmil-images/mine/4yyz) | 11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR | Descriptor: | Corticosteroid 11-beta-dehydrogenase isozyme 1, N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Branden, G, Boden, C, Ogg, D. | Deposit date: | 2015-03-24 | Release date: | 2016-02-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Design of pyrozolo-pyrimidines as 11beta-HSD1 inhibitors through optimisation of molecular electrostatic potential. Medchemcomm, 6, 2016
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2W87
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![BU of 2w87 by Molmil](/molmil-images/mine/2w87) | Xyl-CBM35 in complex with glucuronic acid containing disaccharide. | Descriptor: | CALCIUM ION, ESTERASE D, UNKNOWN LIGAND, ... | Authors: | Montainer, C, Bueren, A.L.v, Dumon, C, Flint, J.E, Correia, M.A, Prates, J.A, Firbank, S.J, Lewis, R.J, Grondin, G.G, Ghinet, M.G, Gloster, T.M, Herve, C, Knox, J.P, Talbot, B.G, Turkenburg, J.P, Kerovuo, J, Brzezinski, R, Fontes, C.M.G.A, Davies, G.J, Boraston, A.B, Gilbert, H.J. | Deposit date: | 2009-01-14 | Release date: | 2009-01-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Evidence that Family 35 Carbohydrate Binding Modules Display Conserved Specificity But Divergent Function. Proc.Natl.Acad.Sci.USA, 106, 2009
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1YSO
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![BU of 1yso by Molmil](/molmil-images/mine/1yso) | YEAST CU, ZN SUPEROXIDE DISMUTASE WITH THE REDUCED BRIDGE BROKEN | Descriptor: | COPPER (I) ION, YEAST CU, ZN SUPEROXIDE DISMUTASE, ... | Authors: | Parge, H.E, Crane, B.R, Tsang, J, Tainer, J.A. | Deposit date: | 1995-12-21 | Release date: | 1996-06-10 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase. Biochemistry, 35, 1996
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4ZG9
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![BU of 4zg9 by Molmil](/molmil-images/mine/4zg9) | Structural basis for inhibition of human autotaxin by four novel compounds | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(11aS)-6-(4-fluorobenzyl)-1,3-dioxo-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indol-2(3H)-yl]propanoic acid, ... | Authors: | Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. | Deposit date: | 2015-04-22 | Release date: | 2015-10-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
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5WNP
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![BU of 5wnp by Molmil](/molmil-images/mine/5wnp) | Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | Descriptor: | 16S Ribosomal RNA rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | DeMirci, H. | Deposit date: | 2017-08-01 | Release date: | 2018-02-21 | Last modified: | 2020-10-21 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | 2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation. Nat. Struct. Mol. Biol., 25, 2018
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