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5K1C
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BU of 5k1c by Molmil
Crystal structure of the UAF1/WDR20/USP12 complex
Descriptor: PHOSPHATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE, Ubiquitin carboxyl-terminal hydrolase 12, ...
Authors:Li, H, D'Andrea, A.D, Zheng, N.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5JWP
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BU of 5jwp by Molmil
Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide.
Descriptor: 2-OXOGLUTARIC ACID, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
Authors:Taabazuing, C.Y, Garman, S.C, Eron, S, Knapp, M.J.
Deposit date:2016-05-12
Release date:2016-11-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.
J.Inorg.Biochem., 166, 2016
2YQM
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BU of 2yqm by Molmil
Solution structure of the FYVE domain in zinc finger FYVE domain-containing protein 12
Descriptor: RUN and FYVE domain-containing protein 1, ZINC ION
Authors:He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-30
Release date:2007-10-02
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the FYVE domain in zinc finger FYVE domain-containing protein 12
To be Published
6N3V
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BU of 6n3v by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Ethyl]Carbamoyl Guanosine
Descriptor: 5'-O-(ethylcarbamoyl)guanosine, CHLORIDE ION, Histidine triad nucleotide-binding protein 1
Authors:Strom, A.M, Finzel, B.C.
Deposit date:2018-11-16
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Acs Chem Neurosci, 10, 2019
5K16
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BU of 5k16 by Molmil
Crystal structure of free Ubiquitin-specific protease 12
Descriptor: GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 12, ZINC ION
Authors:Li, H, D'Andrea, A.D, Zheng, N.
Deposit date:2016-05-17
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
3FEY
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BU of 3fey by Molmil
Crystal structure of the CBC-importin alpha complex.
Descriptor: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2
Authors:Dias, S.M.G, Ambrosio, A.L.B, Cerione, R.A.
Deposit date:2008-12-01
Release date:2009-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The molecular basis for the regulation of the cap-binding complex by the importins.
Nat.Struct.Mol.Biol., 16, 2009
2Y8F
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BU of 2y8f by Molmil
Structure of the Ran-binding domain from human RanBP3 (wild type)
Descriptor: CHLORIDE ION, GLYCEROL, RAN-BINDING PROTEIN 3
Authors:Langer, K, Dian, C, Rybin, V, Muller, C.W, Petosa, C.
Deposit date:2011-02-06
Release date:2011-02-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights Into the Function of the Crm1 Cofactor Ranbp3 from the Structure of its Ran-Binding Domain
Plos One, 6, 2011
2HP7
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BU of 2hp7 by Molmil
Structure of FliM provides insight into assembly of the switch complex in the bacterial flagella motor
Descriptor: Flagellar motor switch protein FliM
Authors:Crane, B.R, Park, S, Lowder, B, Bilwes, A.M, Blair, D.F.
Deposit date:2006-07-17
Release date:2006-08-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of FliM provides insight into assembly of the switch complex in the bacterial flagella motor.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2Y92
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BU of 2y92 by Molmil
Crystal structure of MAL adaptor protein
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN,
Authors:Valkov, E, Stamp, A, Martin, J.L, Kobe, B.
Deposit date:2011-02-11
Release date:2011-09-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection.
Proc.Natl.Acad.Sci.USA, 108, 2011
2HWY
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BU of 2hwy by Molmil
Structure of PIN domain of human SMG5.
Descriptor: Protein SMG5
Authors:Glavan, F, Behm-Ansmant, I, Izaurralde, E, Conti, E.
Deposit date:2006-08-02
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Embo J., 25, 2006
5K28
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BU of 5k28 by Molmil
Structure of the unbound SH3 domain of MLK3
Descriptor: Mitogen-activated protein kinase kinase kinase 11
Authors:Kall, S.K, Lavie, A.
Deposit date:2016-05-18
Release date:2017-12-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
J. Biol. Chem., 293, 2018
3H38
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BU of 3h38 by Molmil
The structure of CCA-adding enzyme apo form II
Descriptor: TRNA nucleotidyl transferase-related protein
Authors:Toh, Y, Tomita, K.
Deposit date:2009-04-16
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme
Embo J., 28, 2009
6T1P
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BU of 6t1p by Molmil
ASR Alternansucrase in complex with isomaltononaose
Descriptor: Alternansucrase, CALCIUM ION, alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose, ...
Authors:Cioci, G, Molina, M, Moulis, C, Remaud-Simeon, M.
Deposit date:2019-10-04
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation.
J.Biol.Chem., 295, 2020
6N3F
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BU of 6n3f by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Leach, J.R, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6N3X
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BU of 6n3x by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Benzyl]Carbamoyl Guanosine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(benzylcarbamoyl)guanosine, CHLORIDE ION, ...
Authors:Strom, A.M, Finzel, B.C.
Deposit date:2018-11-16
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Acs Chem Neurosci, 10, 2019
3OKI
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BU of 3oki by Molmil
Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide
Descriptor: (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-25
Release date:2010-12-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Bioorg.Med.Chem.Lett., 21, 2010
3OMM
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BU of 3omm by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
6N3E
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BU of 6n3e by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
Descriptor: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
Authors:Loerch, S, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2018-11-15
Release date:2019-01-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
5K1B
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BU of 5k1b by Molmil
Crystal structure of the UAF1/USP12 complex in F222 space group
Descriptor: Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, ZINC ION
Authors:Li, H, D'Andrea, A.D, Zheng, N.
Deposit date:2016-05-18
Release date:2016-07-20
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
7C7E
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BU of 7c7e by Molmil
Crystal structure of C terminal domain of Escherichia coli DgoR
Descriptor: Putative DNA-binding transcriptional regulator, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Lin, W.
Deposit date:2020-05-25
Release date:2021-01-20
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket.
Front Microbiol, 11, 2020
3H37
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BU of 3h37 by Molmil
The structure of CCA-adding enzyme apo form I
Descriptor: TRNA nucleotidyl transferase-related protein
Authors:Toh, Y, Tomita, K.
Deposit date:2009-04-16
Release date:2009-10-13
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme
Embo J., 28, 2009
5KCE
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BU of 5kce by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an N-methyl, 2-chlorobenzyl OBHS-N derivative
Descriptor: (1S,2R,4S)-N-(2-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-methyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor, Nuclear receptor coactivator 2
Authors:Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Dharmarajan, V, Goswami, D, Kastrati, I, Novick, S, Nowak, J, Zhou, H.B, Boonmuen, N, Zhao, Y, Min, J, Frasor, J, Katzenellenbogen, B.S, Griffin, P.R, Katzenellenbogen, J.A, Nettles, K.W.
Deposit date:2016-06-06
Release date:2016-11-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.847 Å)
Cite:Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13, 2017
6N7J
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BU of 6n7j by Molmil
BDBV223 Fab bound to synthetic peptide of Bundibugyo virus Glycoprotein Stalk
Descriptor: BDBV223 antibody heavy chain, BDBV223 antibody light chain, Envelope glycoprotein
Authors:King, L.B, West, B.R, Saphire, E.O.
Deposit date:2018-11-27
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.684 Å)
Cite:Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.
Nat Commun, 10, 2019
3OOK
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BU of 3ook by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-31
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
6NLY
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BU of 6nly by Molmil
Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain
Descriptor: Alanine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-09
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020

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