8I5B
| Structure of human Nav1.7 in complex with bupivacaine | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-24 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5X
| Structure of human Nav1.7 in complex with Vinpocetine | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-26 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5Y
| Structure of human Nav1.7 in complex with vixotrigine | Descriptor: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-26 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5G
| Structure of human Nav1.7 in complex with PF-05089771 | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Wu, Q.R, Yan, N. | Deposit date: | 2023-01-25 | Release date: | 2023-06-14 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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4EKW
| Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A) | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | Authors: | Payandeh, J, Gamal El-Din, T.M, Scheuer, T, Zheng, N, Catterall, W.A. | Deposit date: | 2012-04-10 | Release date: | 2012-05-16 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature, 486, 2012
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4F4L
| Open Channel Conformation of a Voltage Gated Sodium Channel | Descriptor: | Ion transport protein | Authors: | McCusker, E.C, Bagneris, C, Naylor, C.E, Cole, A.R, D'Avanzo, N, Nichols, C.G, Wallace, B.A. | Deposit date: | 2012-05-10 | Release date: | 2012-10-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nat Commun, 3, 2012
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4H37
| Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes | Descriptor: | Lmo2059 protein, POTASSIUM ION | Authors: | Santos, J.S, Asmar-Rovira, G.A, Han, G.W, Liu, W, Syeda, R, Cherezov, V, Baker, K.A, Stevens, R.C, Montal, M. | Deposit date: | 2012-09-13 | Release date: | 2012-11-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes. J.Biol.Chem., 287, 2012
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4DXW
| Crystal structure of NavRh, a voltage-gated sodium channel | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | Authors: | Zhang, X, Ren, W.L, Yan, C.Y, Wang, J.W, Yan, N. | Deposit date: | 2012-02-28 | Release date: | 2012-05-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.052 Å) | Cite: | Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel Nature, 486, 2012
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4H33
| Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes, tetragonal crystal form | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lmo2059 protein, POTASSIUM ION | Authors: | Santos, J.S, Asmar-Rovira, G.A, Han, G.W, Liu, W, Syeda, R, Cherezov, V, Baker, K.A, Stevens, R.C, Montal, M. | Deposit date: | 2012-09-13 | Release date: | 2012-11-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes. J.Biol.Chem., 287, 2012
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6WKN
| PL-bound rat TRPV2 in nanodiscs | Descriptor: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | Authors: | Pumroy, R.P, Moiseenkova-Bell, V.Y. | Deposit date: | 2020-04-16 | Release date: | 2021-04-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Acs Cent.Sci., 7, 2021
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2DWE
| Crystal structure of KcsA-FAB-TBA complex in Rb+ | Descriptor: | (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, ANTIBODY FAB HEAVY CHAIN, ANTIBODY FAB LIGHT CHAIN, ... | Authors: | Yohannan, S, Zhou, Y. | Deposit date: | 2006-08-10 | Release date: | 2007-02-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel J.Mol.Biol., 366, 2007
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2DWD
| crystal structure of KcsA-FAB-TBA complex in Tl+ | Descriptor: | (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, ANTIBODY FAB HEAVY CHAIN, ANTIBODY FAB LIGHT CHAIN, ... | Authors: | Yohannan, S, Zhou, Y. | Deposit date: | 2006-08-10 | Release date: | 2007-02-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel J.Mol.Biol., 366, 2007
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6YZ0
| Full length Open-form Sodium Channel NavMs F208L in complex with Cannabidiol (CBD) | Descriptor: | 2-[(1R,2R,5S)-5-methyl-2-(prop-1-en-2-yl)cyclohexyl]-5-pentylbenzene-1,3-diol, DODECAETHYLENE GLYCOL, HEGA-10, ... | Authors: | Sula, A, Sait, L.G, Hollingworth, D, Wallace, B.A. | Deposit date: | 2020-05-06 | Release date: | 2020-11-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cannabidiol interactions with voltage-gated sodium channels. Elife, 9, 2020
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3JAV
| Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | Descriptor: | Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Fan, G, Baker, M.L, Wang, Z, Baker, M.R, Sinyagovskiy, P.A, Chiu, W, Ludtke, S.J, Serysheva, I.I. | Deposit date: | 2015-06-30 | Release date: | 2015-10-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature, 527, 2015
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2H8P
| Structure of a K channel with an amide to ester substitution in the selectivity filter | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB heavy chain, FAB light chain, ... | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | Deposit date: | 2006-06-07 | Release date: | 2006-09-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel. J.Am.Chem.Soc., 128, 2006
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2HFE
| Rb+ complex of a K channel with an amide to ester substitution in the selectivity filter | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB Heavy Chain, FAB Light Chain, ... | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | Deposit date: | 2006-06-23 | Release date: | 2006-09-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel. J.Am.Chem.Soc., 128, 2006
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2HJF
| Potassium channel kcsa-fab complex with tetrabutylammonium (TBA) | Descriptor: | Antibody fragment Heavy chain, Antibody fragment Light chain, POTASSIUM ION, ... | Authors: | Faraldo-Gomez, J.D, Kutluay, E, Jogini, V, Zhao, Y, Heginbotham, L, Roux, B. | Deposit date: | 2006-06-30 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanism of Intracellular Block of the KcsA K(+) Channel by Tetrabutylammonium: Insights from X-ray Crystallography, Electrophysiology and Replica-exchange Molecular Dynamics Simulations. J.Mol.Biol., 365, 2007
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2HG5
| Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter | Descriptor: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, CESIUM ION, FAB HEAVY CHAIN, ... | Authors: | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | Deposit date: | 2006-06-26 | Release date: | 2006-09-12 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel. J.Am.Chem.Soc., 128, 2006
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2HVJ
| Crystal structure of KcsA-Fab-TBA complex in low K+ | Descriptor: | (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Zhou, Y. | Deposit date: | 2006-07-28 | Release date: | 2007-02-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel. J.Mol.Biol., 366, 2007
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2HVK
| crystal structure of the KcsA-Fab-TBA complex in high K+ | Descriptor: | (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, Antibody Fab heavy chain, Antibody Fab light chain, ... | Authors: | Zhou, Y. | Deposit date: | 2006-07-28 | Release date: | 2007-02-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel. J.Mol.Biol., 366, 2007
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2IH3
| Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ... | Authors: | Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R. | Deposit date: | 2006-09-25 | Release date: | 2006-11-21 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation. Science, 314, 2006
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3F7Y
| KcsA Potassium channel in the partially open state with 17 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-10 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | KcsA Potassium channel in the partially open state with 17 A opening at T112 TO BE PUBLISHED
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3F5W
| KcsA Potassium channel in the open-inactivated state with 32 A opening at T112 | Descriptor: | Antibody heavy chain, Antibody light chain, POTASSIUM ION, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-04 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | KcsA Potassium channel in the open-inactivated state with 32 A opening at T112 TO BE PUBLISHED
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5AN8
| Cryo-electron microscopy structure of rabbit TRPV2 ion channel | Descriptor: | TRPV2 | Authors: | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | Deposit date: | 2015-09-04 | Release date: | 2015-12-23 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-Electron Microscopy of the Trpv2 Ion Channel Nat.Struct.Mol.Biol., 23, 2016
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5BZB
| NavMs voltage-gated sodium channel pore and C-terminal domain | Descriptor: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | Authors: | Naylor, C.E, Bagneris, C, Wallace, B.A. | Deposit date: | 2015-06-11 | Release date: | 2016-02-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular basis of ion permeability in a voltage-gated sodium channel. Embo J., 35, 2016
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