6LYI
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6M0W
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![BU of 6m0w by Molmil](/molmil-images/mine/6m0w) | Crystal structure of Streptococcus thermophilus Cas9 in complex with the AGAA PAM | Descriptor: | CRISPR-associated endonuclease Cas9 1, DNA (28-MER), DNA (5'-D(*AP*AP*AP*GP*AP*AP*GP*C)-3'), ... | Authors: | Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q. | Deposit date: | 2020-02-23 | Release date: | 2020-09-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Catalytic-state structure and engineering of Streptococcus thermophilus Cas9 Nat Catal, 2020
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6LK9
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![BU of 6lk9 by Molmil](/molmil-images/mine/6lk9) | Coho salmon ferritin | Descriptor: | Coho salmon ferritin, FE (III) ION | Authors: | Wang, Z, Zang, J, Li, H, Tan, X, Du, M. | Deposit date: | 2019-12-18 | Release date: | 2020-12-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Coho salmon ferritin To Be Published
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5IOT
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6LLB
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![BU of 6llb by Molmil](/molmil-images/mine/6llb) | Crystal structure of mpy-RNase J (mutant S247A), an archaeal RNase J from Methanolobus psychrophilus R15, in complex with 6 nt RNA | Descriptor: | MPY-RNase J, RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3'), SULFATE ION, ... | Authors: | Li, D.F, Hou, Y.J, Guo, L. | Deposit date: | 2019-12-22 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A newly identified duplex RNA unwinding activity of archaeal RNase J depends on processive exoribonucleolysis coupled steric occlusion by its structural archaeal loops. Rna Biol., 17, 2020
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6LXA
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![BU of 6lxa by Molmil](/molmil-images/mine/6lxa) | X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding | Descriptor: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, GLYCEROL, Peroxisome proliferator-activated receptor alpha | Authors: | Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. | Deposit date: | 2020-02-10 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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6LS6
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2G0Q
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![BU of 2g0q by Molmil](/molmil-images/mine/2g0q) | Solution structure of At5g39720.1 from Arabidopsis thaliana | Descriptor: | AT5G39720.1 protein | Authors: | Volkman, B.F, Peterson, F.C, Lytle, B.L, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2006-02-13 | Release date: | 2006-02-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family. Acta Crystallogr.,Sect.F, 62, 2006
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5HRR
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![BU of 5hrr by Molmil](/molmil-images/mine/5hrr) | HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002 | Descriptor: | (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... | Authors: | Nolte, R.T. | Deposit date: | 2016-01-24 | Release date: | 2016-12-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
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7D42
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2G2Y
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![BU of 2g2y by Molmil](/molmil-images/mine/2g2y) | Structure of E.coli FabD complexed with malonate | Descriptor: | MALONATE ION, Malonyl CoA-acyl carrier protein transacylase | Authors: | Oefner, C. | Deposit date: | 2006-02-17 | Release date: | 2006-05-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr.,Sect.D, 62, 2006
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2FXD
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![BU of 2fxd by Molmil](/molmil-images/mine/2fxd) | X-ray crystal structure of HIV-1 protease IRM mutant complexed with atazanavir (BMS-232632) | Descriptor: | (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER, ACETATE ION, ... | Authors: | Klei, H.E, Sheriff, S. | Deposit date: | 2006-02-04 | Release date: | 2007-02-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir. J.Virol., 81, 2007
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2R8Z
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![BU of 2r8z by Molmil](/molmil-images/mine/2r8z) | Crystal structure of YrbI phosphatase from Escherichia coli in complex with a phosphate and a calcium ion | Descriptor: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, CALCIUM ION, PHOSPHATE ION | Authors: | Tsodikov, O.V, Aggarwal, P, Rubin, J.R, Stuckey, J.A, Woodard, R.W, Biswas, T. | Deposit date: | 2007-09-11 | Release date: | 2008-09-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE. J.Biol.Chem., 284, 2009
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2FXP
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2FXZ
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2RAC
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![BU of 2rac by Molmil](/molmil-images/mine/2rac) | AMICYANIN REDUCED, PH 7.7, 1.3 ANGSTROMS | Descriptor: | COPPER (I) ION, PROTEIN (AMICYANIN) | Authors: | Cunane, L.M, Chen, Z.-W, Durley, R.C.E, Mathews, F.S. | Deposit date: | 1998-10-02 | Release date: | 1998-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Molecular basis for interprotein complex-dependent effects on the redox properties of amicyanin. Biochemistry, 37, 1998
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5HT1
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![BU of 5ht1 by Molmil](/molmil-images/mine/5ht1) | Structure of apo C. glabrata FKBP12 | Descriptor: | FK506-binding protein 1 | Authors: | Schumacher, M.A. | Deposit date: | 2016-01-26 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.651 Å) | Cite: | Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
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5HT6
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![BU of 5ht6 by Molmil](/molmil-images/mine/5ht6) | Crystal structure of the SET domain of the human MLL5 methyltransferase | Descriptor: | Histone-lysine N-methyltransferase 2E | Authors: | le Maire, A, Mas-y-Mas, S, Dumas, C, Lebedev, A. | Deposit date: | 2016-01-26 | Release date: | 2016-11-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.093 Å) | Cite: | The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. Plos One, 11, 2016
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6XD3
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![BU of 6xd3 by Molmil](/molmil-images/mine/6xd3) | Structure of the human CAK in complex with THZ1 | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | Deposit date: | 2020-06-09 | Release date: | 2020-09-09 | Last modified: | 2020-09-30 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The cryoelectron microscopy structure of the human CDK-activating kinase. Proc.Natl.Acad.Sci.USA, 117, 2020
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7D5L
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![BU of 7d5l by Molmil](/molmil-images/mine/7d5l) | Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection | Descriptor: | NS3/4A Protease, ZINC ION, [1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl] ~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate | Authors: | Ghosh, K, Anumula, R, Kumar, A. | Deposit date: | 2020-09-26 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 63, 2020
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2G4O
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![BU of 2g4o by Molmil](/molmil-images/mine/2g4o) | anomalous substructure of 3-ISOPROPYLMALATE DEHYDROGENASE | Descriptor: | 3-isopropylmalate dehydrogenase, CHLORIDE ION, SULFATE ION | Authors: | Mueller-Dieckmann, C, Weiss, M.S. | Deposit date: | 2006-02-22 | Release date: | 2007-02-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr.,Sect.D, 63, 2007
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5HVT
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![BU of 5hvt by Molmil](/molmil-images/mine/5hvt) | Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2) | Descriptor: | 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, GLYCEROL, ISOPROPYL ALCOHOL, ... | Authors: | Robertson, M.J, Jorgensen, W.L. | Deposit date: | 2016-01-28 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138, 2016
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2R6E
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![BU of 2r6e by Molmil](/molmil-images/mine/2r6e) | Crystal Form B2 | Descriptor: | Replicative helicase, SULFATE ION | Authors: | Bailey, S, Eliason, W.K, Steitz, T.A. | Deposit date: | 2007-09-05 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (5.019 Å) | Cite: | Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase Science, 318, 2007
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5HW8
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2G1H
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![BU of 2g1h by Molmil](/molmil-images/mine/2g1h) | Structure of E.coli FabD complexed with glycerol | Descriptor: | GLYCEROL, Malonyl CoA-acyl carrier protein transacylase | Authors: | Oefner, C. | Deposit date: | 2006-02-14 | Release date: | 2006-05-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr.,Sect.D, 62, 2006
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