1PYW
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![BU of 1pyw by Molmil](/molmil-images/mine/1pyw) | Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2) | Descriptor: | 9-residue influenza virus hemagglutinin related peptide FVKQNA(MAA)AL, Enterotoxin type C-3, HLA class II histocompatibility antigen, ... | Authors: | Zavala-Ruiz, Z, Sundberg, E.J, Stone, J.D, DeOliveira, D.B, Chan, I.C, Svendsen, J, Mariuzza, R.A, Stern, L.J. | Deposit date: | 2003-07-09 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Exploration of the P6/P7 region of the peptide-binding site of the human class II Major Histocompatability Complex Protein HLA-DR1 J.Biol.Chem., 278, 2003
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1CLO
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![BU of 1clo by Molmil](/molmil-images/mine/1clo) | |
3GSX
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![BU of 3gsx by Molmil](/molmil-images/mine/3gsx) | Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8V peptide variant | Descriptor: | Beta-2-microglobulin, HCMV pp65 fragment 495-503, variant T8V (NLVPMVAVV), ... | Authors: | Reiser, J.-B, Saulquin, X, Gras, S, Debeaupuis, E, Echasserieau, K, Kissenpfennig, A, Legoux, F, Chouquet, A, Le Gorrec, M, Machillot, P, Neveu, B, Thielens, N, Malissen, B, Bonneville, M, Housset, D. | Deposit date: | 2009-03-27 | Release date: | 2009-08-04 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope. J.Immunol., 183, 2009
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3DTX
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![BU of 3dtx by Molmil](/molmil-images/mine/3dtx) | Crystal structure of HLA-B*2705 complexed with the double citrullinated vasoactive intestinal peptide type 1 receptor (VIPR) peptide (residues 400-408) | Descriptor: | Beta-2-microglobulin, Double citrullinated vasoactive intestinal polypeptide receptor, MHC class I antigen (Fragment) | Authors: | Beltrami, A, Gabdulkhakov, A, Rossmann, M, Ziegler, A, Uchanska-Ziegler, B, Saenger, W. | Deposit date: | 2008-07-16 | Release date: | 2009-05-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Citrullination-and mhc polymorphism-dependent conformational changes of a self peptide To be Published
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6BIZ
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![BU of 6biz by Molmil](/molmil-images/mine/6biz) | HLA-DRB1 in complex with citrullinated Histone 2B peptide | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II DR-beta (HLA-DR B), ... | Authors: | Ting, Y.T, Scally, S.W, Rossjohn, J. | Deposit date: | 2017-11-03 | Release date: | 2018-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis. J. Biol. Chem., 293, 2018
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1XGU
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![BU of 1xgu by Molmil](/molmil-images/mine/1xgu) | Structure for antibody HyHEL-63 Y33F mutant complexed with hen egg lysozyme | Descriptor: | Lysozyme C, antibody kappa heavy chain, antibody kappa light chain | Authors: | Li, Y, Huang, Y, Swaminathan, C.P, Smith-Gill, S.J, Mariuzza, R.A. | Deposit date: | 2004-09-17 | Release date: | 2005-09-06 | Last modified: | 2013-10-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces Structure, 13, 2005
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3IXA
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![BU of 3ixa by Molmil](/molmil-images/mine/3ixa) | |
2ZOK
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![BU of 2zok by Molmil](/molmil-images/mine/2zok) | Crystal structure of H-2Db in complex with JHMV epitope S510 | Descriptor: | 9-meric peptide from Spike glycoprotein, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Theodossis, A, Dunstone, M.A, Rossjohn, J. | Deposit date: | 2008-05-22 | Release date: | 2008-06-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol., 180, 2008
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3RWG
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![BU of 3rwg by Molmil](/molmil-images/mine/3rwg) | Rhesus macaque MHC class I molecule Mamu-B*17-MW9 | Descriptor: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wu, Y, Gao, F, Liu, J, Qi, J.X, Price, D.A, Gao, G.F. | Deposit date: | 2011-05-09 | Release date: | 2012-03-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus J.Immunol., 187, 2011
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1SY6
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![BU of 1sy6 by Molmil](/molmil-images/mine/1sy6) | Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment | Descriptor: | OKT3 Fab heavy chain, OKT3 Fab light chain, T-cell surface glycoprotein CD3 gamma/epsilon chain | Authors: | Kjer-Nielsen, L, Dunstone, M.A, Kostenko, L, Ely, L.K, Beddoe, T, Misfud, N.A, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J. | Deposit date: | 2004-03-31 | Release date: | 2004-05-25 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the human T cell receptor CD3(epsilon)(gamma) heterodimer complexed to the therapeutic mAb OKT3. Proc.Natl.Acad.Sci.USA, 101, 2004
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1JGE
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![BU of 1jge by Molmil](/molmil-images/mine/1jge) | HLA-B*2705 bound to nona-peptide m9 | Descriptor: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-27 B*2705 ALPHA CHAIN, ... | Authors: | Hulsmeyer, M, Hillig, R.C, Volz, A, Ruhl, M, Schroder, W, Saenger, W, Ziegler, A, Uchanska-Ziegler, B. | Deposit date: | 2001-06-25 | Release date: | 2002-10-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | HLA-B27 subtypes differentially associated with disease exhibit subtle structural
alterations J.Biol.Chem., 277, 2002
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1YEK
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![BU of 1yek by Molmil](/molmil-images/mine/1yek) | CATALYTIC ANTIBODY D2.3 COMPLEX | Descriptor: | P-NITROPHENOL, PROTEIN (IG ANTIBODY D2.3 (HEAVY CHAIN)), PROTEIN (IG ANTIBODY D2.3 (LIGHT CHAIN)), ... | Authors: | Gigant, B, Knossow, M. | Deposit date: | 1998-08-13 | Release date: | 1999-01-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crossreactivity, efficiency and catalytic specificity of an esterase-like antibody. J.Mol.Biol., 284, 1998
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3E6H
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![BU of 3e6h by Molmil](/molmil-images/mine/3e6h) | MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PI10, from the human immunodeficiency virus (BaL) envelope glycoprotein 120 | Descriptor: | Envelope glycoprotein 10-residue peptide, H-2 class I histocompatibility antigen, D-D alpha chain, ... | Authors: | Wang, R, Natarajan, K, Robinson, H, Margulies, D.H. | Deposit date: | 2008-08-15 | Release date: | 2009-08-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity J.Immunol., 183, 2009
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1T80
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![BU of 1t80 by Molmil](/molmil-images/mine/1t80) | Zn-alpha-2-glycoprotein; CHO-ZAG PEG 200 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Zinc-alpha-2-glycoprotein | Authors: | Delker, S.L, West Jr, A.P, McDermott, L, Kennedy, M.W, Bjorkman, P.J. | Deposit date: | 2004-05-11 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein. J.Struct.Biol., 148, 2004
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4HS3
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![BU of 4hs3 by Molmil](/molmil-images/mine/4hs3) | Crystal structure of H-2Kb with a disulfide stabilized F pocket in complex with the LCMV derived peptide GP34 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-2-microglobulin, Envelope glycoprotein, ... | Authors: | Uchtenhagen, H, Boulanger, B, Hein, Z, Abualrous, E.T, Zacharias, M, Werner, J, Elliott, T, Springer, S, Achour, A. | Deposit date: | 2012-10-29 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Peptide-independent stabilization of MHC class I molecules breaches cellular quality control. J.Cell.Sci., 127, 2014
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4NO5
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![BU of 4no5 by Molmil](/molmil-images/mine/4no5) | Crystal structure of non-phosphorylated form of AMPD2 phosphopeptide bound to HLA-A2 | Descriptor: | 1,2-ETHANEDIOL, AMP deaminase 2, Beta-2-microglobulin, ... | Authors: | Mohammed, F, Stones, D.H, Willcox, B.E. | Deposit date: | 2013-11-19 | Release date: | 2014-12-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status. Oncotarget, 8, 2017
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4NNX
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![BU of 4nnx by Molmil](/molmil-images/mine/4nnx) | Crystal structure of PKD2 phosphopeptide bound to HLA-A2 | Descriptor: | Beta-2-microglobulin, CADMIUM ION, GLYCEROL, ... | Authors: | Mohammed, F, Stones, D.H, Willcox, B.E. | Deposit date: | 2013-11-19 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status. Oncotarget, 8, 2017
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8W84
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![BU of 8w84 by Molmil](/molmil-images/mine/8w84) | HLA-DQ2.5-alpha2 gliadin peptide in complex with DQN0344AE02 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DQN0344AE02 Fab heavy chain, DQN0344AE02 Fab light chain, ... | Authors: | Irie, M, Tsushima, T, Teranishi-Ikawa, Y, Takahashi, N, Ishii, S, Okura, Y, Fukami, T.A, Torizawa, T. | Deposit date: | 2023-08-31 | Release date: | 2023-11-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease. Nat Commun, 14, 2023
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6SSA
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![BU of 6ssa by Molmil](/molmil-images/mine/6ssa) | Human Leukocyte Antigen Class I A02 Carrying LLWNGPMQV | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CALCIUM ION, ... | Authors: | Rizkallah, P.J, Bovay, A. | Deposit date: | 2019-09-06 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222by combinatorial peptide library screening. Mol.Immunol., 125, 2020
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7MXH
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![BU of 7mxh by Molmil](/molmil-images/mine/7mxh) | CD1c with antigen analogue 3 | Descriptor: | (2S)-2,3-dihydroxypropyl hexadecanoate, 2,6-anhydro-1-deoxy-1,1-difluoro-1-[(R)-hydroxy{[(4S,8S,12S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-D-glycero-D-galacto-heptitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Cao, T.P, Shahine, A, Rossjohn, J. | Deposit date: | 2021-05-19 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. J.Biol.Chem., 297, 2021
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4JFO
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![BU of 4jfo by Molmil](/molmil-images/mine/4jfo) | A2 HLA complex with E1A heteroclitic variant of Melanoma peptide | Descriptor: | Beta-2-microglobulin, E1A heteroclitic Melanoma peptide, GLYCEROL, ... | Authors: | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M. | Deposit date: | 2013-02-28 | Release date: | 2013-05-29 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288, 2013
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8EK5
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![BU of 8ek5 by Molmil](/molmil-images/mine/8ek5) | Engineered scFv 10LH bound to PHOX2B/HLA-A24:02 | Descriptor: | 10LH single chain fragment variable (scFv), Beta-2-microglobulin, GLYCEROL, ... | Authors: | Garfinkle, S.E, Florio, T.J, Sgourakis, N.G. | Deposit date: | 2022-09-20 | Release date: | 2023-12-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
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1W0W
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![BU of 1w0w by Molmil](/molmil-images/mine/1w0w) | Crystal Structure Of HLA-B*2709 Complexed With the self-Peptide TIS from EGF-response factor 1 | Descriptor: | BETA-2-MICROGLOBULIN, BUTYRATE RESPONSE FACTOR 2, GLYCEROL, ... | Authors: | Hulsmeyer, M, Fiorillo, M.T, Bettosini, F, Sorrentino, R, Saenger, W, Ziegler, A, Uchanska-Ziegler, B. | Deposit date: | 2004-06-14 | Release date: | 2005-03-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Thermodynamic and Structural Equivalence of Two Hla-B27 Subtypes Complexed with a Self-Peptide J.Mol.Biol., 346, 2005
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7EJN
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![BU of 7ejn by Molmil](/molmil-images/mine/7ejn) | |
5C07
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![BU of 5c07 by Molmil](/molmil-images/mine/5c07) | 1E6 TCR in complex with HLA-A02 carrying YQFGPDFPIA | Descriptor: | 1,2-ETHANEDIOL, 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, ... | Authors: | Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K. | Deposit date: | 2015-06-12 | Release date: | 2016-05-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. J.Clin.Invest., 126, 2016
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