1R16
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![BU of 1r16 by Molmil](/molmil-images/mine/1r16) | Aplysia ADP ribosyl cyclase with bound pyridylcarbinol and R5P | Descriptor: | 3-PYRIDINYLCARBINOL, ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE | Authors: | Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q. | Deposit date: | 2003-09-23 | Release date: | 2004-03-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure, 12, 2004
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3IVF
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![BU of 3ivf by Molmil](/molmil-images/mine/3ivf) | Crystal structure of the talin head FERM domain | Descriptor: | Talin-1 | Authors: | Elliott, P.R, Goult, B.T, Bate, N, Grossmann, J.G, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | Deposit date: | 2009-09-01 | Release date: | 2010-08-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | The Structure of the talin head reveals a novel extended conformation of the FERM domain Structure, 18, 2010
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1R55
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![BU of 1r55 by Molmil](/molmil-images/mine/1r55) | Crystal structure of the catalytic domain of human ADAM 33 | Descriptor: | (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, ADAM 33, CALCIUM ION, ... | Authors: | Orth, P, Reichert, P, Wang, W, Prosise, W.W, Yarosh-Tomaine, T, Hammond, G, Xiao, L, Mirza, U.A, Zou, J, Strickland, C, Taremi, S.S, Le, H.V, Madison, V. | Deposit date: | 2003-10-09 | Release date: | 2004-10-12 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structre of the catalytic domain of human ADAM33 J.Mol.Biol., 335, 2004
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5IVV
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![BU of 5ivv by Molmil](/molmil-images/mine/5ivv) | |
5IWG
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![BU of 5iwg by Molmil](/molmil-images/mine/5iwg) | HDAC2 WITH LIGAND BRD4884 | Descriptor: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Steinbacher, S. | Deposit date: | 2016-03-22 | Release date: | 2016-08-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
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3IPU
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![BU of 3ipu by Molmil](/molmil-images/mine/3ipu) | X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha | Descriptor: | 4-{[methyl(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)carbamoyl]amino}benzoic acid, Nuclear receptor coactivator 1, Oxysterols receptor LXR-alpha, ... | Authors: | Fradera, X, Vu, D, Nimz, O, Skene, R, Hosfield, D, Wijnands, R, Cooke, A.J, Haunso, A, King, A, Bennet, D.J, McGuire, R, Uitdehaag, J.C.M. | Deposit date: | 2009-08-18 | Release date: | 2010-06-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. J.Mol.Biol., 399, 2010
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5J7T
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1BSE
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![BU of 1bse by Molmil](/molmil-images/mine/1bse) | |
1RBP
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![BU of 1rbp by Molmil](/molmil-images/mine/1rbp) | |
5J0O
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![BU of 5j0o by Molmil](/molmil-images/mine/5j0o) | |
5J0W
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4XOI
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![BU of 4xoi by Molmil](/molmil-images/mine/4xoi) | Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution | Descriptor: | Actin-binding protein anillin, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sun, L, Guan, R, Lee, I.-J, Liu, Y, Chen, M, Wang, J, Wu, J, Chen, Z. | Deposit date: | 2015-01-16 | Release date: | 2015-07-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.092 Å) | Cite: | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
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4XOZ
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![BU of 4xoz by Molmil](/molmil-images/mine/4xoz) | Crystal structure of ERK2 in complex with an inhibitor | Descriptor: | Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION | Authors: | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | Deposit date: | 2015-01-16 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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5ITT
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![BU of 5itt by Molmil](/molmil-images/mine/5itt) | Crystal Structure of Human NEIL1 bound to duplex DNA containing THF | Descriptor: | DNA (26-MER), Endonuclease 8-like 1, GLYCEROL | Authors: | Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, Y, Yi, C. | Deposit date: | 2016-03-17 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA, 113, 2016
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3I85
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1RKH
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![BU of 1rkh by Molmil](/molmil-images/mine/1rkh) | crystal structure of the rat vitamin D receptor ligand binding domain complexed with 2AM20R and a synthetic peptide containing the NR2 box of DRIP 205 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYL-CYCLOHEXANE-1,3-DIOL, Peroxisome proliferator-activated receptor binding protein, Vitamin D3 receptor | Authors: | Vanhooke, J.L, Benning, M.M, Bauer, C.B, Pike, J.W, F DeLuca, H. | Deposit date: | 2003-11-21 | Release date: | 2004-04-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Molecular Structure of the Rat Vitamin D Receptor Ligand Binding Domain Complexed with 2-Carbon-Substituted Vitamin D(3) Hormone Analogues and a LXXLL-Containing Coactivator Peptide Biochemistry, 43, 2004
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5ITU
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![BU of 5itu by Molmil](/molmil-images/mine/5itu) | Crystal Structure of Human NEIL1(242K) bound to duplex DNA containing THF | Descriptor: | DNA (5'-D(*CP*GP*TP*CP*CP*AP*CP*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3'), Endonuclease 8-like 1 | Authors: | Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, Y, Yi, C. | Deposit date: | 2016-03-17 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA, 113, 2016
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1BU8
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![BU of 1bu8 by Molmil](/molmil-images/mine/1bu8) | RAT PANCREATIC LIPASE RELATED PROTEIN 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (PANCREATIC LIPASE RELATED PROTEIN 2) | Authors: | Roussel, A, Cambillau, C. | Deposit date: | 1998-09-14 | Release date: | 1998-12-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and activity of rat pancreatic lipase-related protein 2. J.Biol.Chem., 273, 1998
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4XBF
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![BU of 4xbf by Molmil](/molmil-images/mine/4xbf) | Structure of LSD1:CoREST in complex with ssRNA | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | Authors: | Luka, Z, Loukachevitch, L.V, Martin, W.J, Wagner, C, Reiter, N.J. | Deposit date: | 2014-12-16 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme. RNA, 22, 2016
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5IX0
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![BU of 5ix0 by Molmil](/molmil-images/mine/5ix0) | HDAC2 WITH LIGAND BRD7232 | Descriptor: | (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... | Authors: | Steinbacher, S. | Deposit date: | 2016-03-23 | Release date: | 2016-08-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
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5TO8
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![BU of 5to8 by Molmil](/molmil-images/mine/5to8) | Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency | Descriptor: | 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6H)-one, Protein-tyrosine kinase 2-beta | Authors: | Newby, Z.E. | Deposit date: | 2016-10-17 | Release date: | 2016-12-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.9849 Å) | Cite: | Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency. Bioorg. Med. Chem. Lett., 26, 2016
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3IDO
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3II0
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![BU of 3ii0 by Molmil](/molmil-images/mine/3ii0) | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) | Descriptor: | 1,2-ETHANEDIOL, Aspartate aminotransferase, cytoplasmic, ... | Authors: | Ugochukwu, E, Pilka, E, Cooper, C, Bray, J.E, Yue, W.W, Muniz, J, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2009-07-31 | Release date: | 2009-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) To be Published
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1C3K
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![BU of 1c3k by Molmil](/molmil-images/mine/1c3k) | CRYSTAL STRUCTURE OF HELIANTHUS TUBEROSUS LECTIN | Descriptor: | AGGLUTININ | Authors: | Bourne, Y, Zamboni, V, Barre, A, Peumans, W.J, van Damme, E.J.M, Rouge, P. | Deposit date: | 1999-07-28 | Release date: | 2000-01-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins. Structure Fold.Des., 7, 1999
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4XZP
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![BU of 4xzp by Molmil](/molmil-images/mine/4xzp) | |