5WAA
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![BU of 5waa by Molmil](/molmil-images/mine/5waa) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) C84R mutant | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1 | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2017-06-26 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.098 Å) | Cite: | Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia. J. Mol. Biol., 430, 2018
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6H1B
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![BU of 6h1b by Molmil](/molmil-images/mine/6h1b) | Structure of amide bond synthetase Mcba K483A mutant from Marinactinospora thermotolerans | Descriptor: | 1-ethanoyl-9~{H}-pyrido[3,4-b]indole-3-carboxylic acid, ADENOSINE MONOPHOSPHATE, Fatty acid CoA ligase | Authors: | Rowlinson, B, Petchey, M, Cuetos, A, Frese, A, Dannevald, S, Grogan, G. | Deposit date: | 2018-07-11 | Release date: | 2018-09-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides. Angew. Chem. Int. Ed. Engl., 57, 2018
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2QO7
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![BU of 2qo7 by Molmil](/molmil-images/mine/2qo7) | Human EphA3 kinase and juxtamembrane region, dephosphorylated, AMP-PNP bound | Descriptor: | BETA-MERCAPTOETHANOL, Ephrin receptor, GLYCEROL, ... | Authors: | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-20 | Release date: | 2007-08-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.605 Å) | Cite: | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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1J59
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![BU of 1j59 by Molmil](/molmil-images/mine/1j59) | CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | Descriptor: | 5'-D(*AP*TP*AP*TP*GP*TP*CP*AP*CP*AP*CP*TP*TP*TP*TP*CP*G )-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*GP*TP*GP*TP*GP*AP*C)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | Authors: | Parkinson, G, Wilson, C, Gunasekera, A, Ebright, Y.W, Ebright, R.H, Berman, H.M. | Deposit date: | 2002-03-01 | Release date: | 2002-03-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface. J.Mol.Biol., 260, 1996
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8SF8
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![BU of 8sf8 by Molmil](/molmil-images/mine/8sf8) | Structure of bovine PKA bound to (R)-N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)-2-amino-4-methylpentanamide | Descriptor: | N-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-D-leucinamide, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | Authors: | Coker, J.A, Arya, T, Goins, C.M, Maw, J.J, Macdonald, J.D, Stauffer, S.R. | Deposit date: | 2023-04-10 | Release date: | 2024-02-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase. J.Med.Chem., 67, 2024
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1RUO
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![BU of 1ruo by Molmil](/molmil-images/mine/1ruo) | CATABOLITE GENE ACTIVATOR PROTEIN (CAP) MUTANT/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*TP*CP*G )-3'), DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), ... | Authors: | Parkinson, G.N, Ebright, R.H, Berman, H.M. | Deposit date: | 1996-05-26 | Release date: | 1997-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat.Struct.Biol., 3, 1996
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1RUN
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![BU of 1run by Molmil](/molmil-images/mine/1run) | CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*TP*CP*G )-3'), DNA (5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), ... | Authors: | Parkinson, G.N, Gunasekera, A, Vojtechovsky, J, Zhang, X, Kunkel, T.A, Berman, H.M, Ebright, R.H. | Deposit date: | 1996-05-26 | Release date: | 1997-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat.Struct.Biol., 3, 1996
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2QOC
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![BU of 2qoc by Molmil](/molmil-images/mine/2qoc) | Human EphA3 kinase domain, phosphorylated, AMP-PNP bound structure | Descriptor: | BETA-MERCAPTOETHANOL, Ephrin receptor, MAGNESIUM ION, ... | Authors: | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-20 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QOQ
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![BU of 2qoq by Molmil](/molmil-images/mine/2qoq) | Human EphA3 kinase and juxtamembrane region, base, AMP-PNP bound structure | Descriptor: | Ephrin receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Loppnau, P, Allali-Hassani, A, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-20 | Release date: | 2007-10-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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2QO9
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![BU of 2qo9 by Molmil](/molmil-images/mine/2qo9) | Human EphA3 kinase and juxtamembrane region, phosphorylated, AMP-PNP bound | Descriptor: | Ephrin receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Davis, T, Walker, J.R, Newman, E.M, Mackenzie, F, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-20 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). Structure, 16, 2008
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3GMT
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![BU of 3gmt by Molmil](/molmil-images/mine/3gmt) | Crystal structure of adenylate kinase from burkholderia pseudomallei | Descriptor: | Adenylate kinase, SULFATE ION | Authors: | Abendroth, J, Staker, B.L, Robinson, H, Buchko, G.W, Hewitt, S.N, Napuli, A.J, Van Voorhis, W, Stacy, R, Myler, P.J, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2009-03-15 | Release date: | 2009-06-02 | Last modified: | 2013-10-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. Biochem.Biophys.Res.Commun., 394, 2010
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2QLL
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![BU of 2qll by Molmil](/molmil-images/mine/2qll) | Human liver glycogen phosphorylase- GL complex | Descriptor: | Glycogen phosphorylase, liver form, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Pautsch, A, Streicher, R, Wissdorf, O, Stadler, N. | Deposit date: | 2007-07-13 | Release date: | 2008-02-19 | Last modified: | 2013-03-13 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylase. J.Biol.Chem., 283, 2008
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4YAF
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![BU of 4yaf by Molmil](/molmil-images/mine/4yaf) | rat CYPOR with 2'-AMP | Descriptor: | ADENOSINE-2'-MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Xia, C, Kim, J.J.P. | Deposit date: | 2015-02-17 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J.Biol.Chem., 291, 2016
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4YIY
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![BU of 4yiy by Molmil](/molmil-images/mine/4yiy) | Structure of MRB1590 bound to AMP-PNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, kRNA Editing A6 Specific Protein | Authors: | Shaw, P.L.R, Schumacher, M.A. | Deposit date: | 2015-03-02 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.016 Å) | Cite: | Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. Nucleic Acids Res., 43, 2015
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4YAL
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![BU of 4yal by Molmil](/molmil-images/mine/4yal) | Reduced CYPOR with 2'-AMP | Descriptor: | ADENOSINE-2'-MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Xia, C, Kim, J.J.P. | Deposit date: | 2015-02-17 | Release date: | 2016-03-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J.Biol.Chem., 291, 2016
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1ZWJ
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![BU of 1zwj by Molmil](/molmil-images/mine/1zwj) | X-ray structure of galt-like protein from arabidopsis thaliana AT5G18200 | Descriptor: | ZINC ION, putative galactose-1-phosphate uridyl transferase | Authors: | Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, McCoy, J.G, Johnson, K.A, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2005-06-03 | Release date: | 2005-06-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Mechanism of an ADP-Glucose Phosphorylase from
Arabidopsis thaliana Biochemistry, 45, 2006
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2J2I
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![BU of 2j2i by Molmil](/molmil-images/mine/2j2i) | Crystal Structure of the humab PIM1 in complex with LY333531 | Descriptor: | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION | Authors: | Debreczeni, J.E, Bullock, A.N, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S. | Deposit date: | 2006-08-16 | Release date: | 2007-02-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc. Natl. Acad. Sci. U.S.A., 104, 2007
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3FIU
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![BU of 3fiu by Molmil](/molmil-images/mine/3fiu) | Structure of NMN synthetase from Francisella tularensis | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase, ... | Authors: | Sorci, L, Martynowski, D, Eyobo, Y, Osterman, A.L, Zhang, H. | Deposit date: | 2008-12-12 | Release date: | 2009-03-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis Proc.Natl.Acad.Sci.USA, 106, 2009
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2HIX
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![BU of 2hix by Molmil](/molmil-images/mine/2hix) | |
3TUX
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![BU of 3tux by Molmil](/molmil-images/mine/3tux) | Crystal structure of RtcA.ATP.Mn ternary complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Chakravarty, A.K, Smith, P, Shuman, S. | Deposit date: | 2011-09-19 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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2HIV
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![BU of 2hiv by Molmil](/molmil-images/mine/2hiv) | ATP-dependent DNA ligase from S. solfataricus | Descriptor: | Thermostable DNA ligase | Authors: | Pascal, J.M, Ellenberger, T. | Deposit date: | 2006-06-29 | Release date: | 2006-11-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA. Mol.Cell, 24, 2006
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3TW3
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![BU of 3tw3 by Molmil](/molmil-images/mine/3tw3) | Crystal structure of RtcA.ATP.Co ternary complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, COBALT (II) ION, RNA 3'-terminal phosphate cyclase, ... | Authors: | Chakravarty, A.K, Smith, P, Shuman, S. | Deposit date: | 2011-09-21 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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2LXT
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![BU of 2lxt by Molmil](/molmil-images/mine/2lxt) | Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core | Descriptor: | CREB-binding protein, Cyclic AMP-responsive element-binding protein 1, Histone-lysine N-methyltransferase MLL | Authors: | Bruschweiler, S, Schanda, P, Konrat, R, Tollinger, M. | Deposit date: | 2012-08-31 | Release date: | 2013-06-12 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core. Acs Chem.Biol., 8, 2013
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3TUT
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![BU of 3tut by Molmil](/molmil-images/mine/3tut) | Crystal structure of RtcA.ATP binary complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Chakravarty, A.K, Smith, P, Shuman, S. | Deposit date: | 2011-09-18 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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5E7I
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![BU of 5e7i by Molmil](/molmil-images/mine/5e7i) | |