PDB: 19255 resultsInfo pagesStatus searchChemie searchBIRD

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8EAE	Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI Descriptor: Cyclic GMP-AMP synthase, MAGNESIUM ION, Palindromic DNA18, ... Authors: Wu, S, Sohn, J. Deposit date: 2022-08-29 Release date: 2023-10-25 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.56 Å) Cite: The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS. Nat Commun, 15, 2024
8ECC	Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ... Authors: Wu, S, Sohn, J. Deposit date: 2022-09-01 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA To Be Published
1PME	STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE Descriptor: 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, ERK2, SULFATE ION Authors: Xie, X. Deposit date: 1998-06-08 Release date: 1999-06-08 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2 Å) Cite: A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci., 7, 1998
2WKY	Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP Descriptor: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2009-06-18 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization J.Med.Chem., 52, 2009
1PXU	Crystal structure of chicken NtA from a eukaryotic source at 2.2A resolution Descriptor: agrin Authors: Stetefeld, J. Deposit date: 2003-07-07 Release date: 2004-06-29 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure and laminin-binding specificity of the NtA domain expressed in eukaryotic cells. Matrix Biol., 23, 2005
1PZ8	Modulation of agrin function by alternative splicing and Ca2+ binding Descriptor: Agrin, CALCIUM ION Authors: Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. Deposit date: 2003-07-10 Release date: 2004-04-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Modulation of agrin function by alternative splicing and Ca2+ binding. STRUCTURE, 12, 2004
2RM0	FBP28WW2 domain in complex with a PPPLIPPPP peptide Descriptor: Formin-1, Transcription elongation regulator 1 Authors: Ramirez-Espain, X, Ruiz, L, Martin-Malpartida, P, Oschkinat, H, Macias, M.J. Deposit date: 2007-09-06 Release date: 2007-11-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural Characterization of a New Binding Motif and a Novel Binding Mode in Group 2 WW Domains J.Mol.Biol., 373, 2007
2RLY	FBP28WW2 domain in complex with PTPPPLPP peptide Descriptor: Formin-1, Transcription elongation regulator 1 Authors: Ramirez-Espain, X, Ruiz, L, Martin-Malpartida, P, Oschkinat, H, Macias, M.J. Deposit date: 2007-09-03 Release date: 2007-11-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural Characterization of a New Binding Motif and a Novel Binding Mode in Group 2 WW Domains J.Mol.Biol., 373, 2007
2UW6	Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine Descriptor: (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... Authors: Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A. Deposit date: 2007-03-19 Release date: 2007-05-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery J.Med.Chem., 50, 2007
1Q62	PKA double mutant model of PKB Descriptor: cAMP-dependent protein kinase inhibitor, alpha form, cAMP-dependent protein kinase, ... Authors: Gassel, M, Breitenlechner, C.B, Rueger, P, Jucknischke, U, Schneider, T, Huber, R, Bossemeyer, D, Engh, R.A. Deposit date: 2003-08-12 Release date: 2003-09-30 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT) J.Mol.Biol., 329, 2003
2UVZ	Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine Descriptor: (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... Authors: Davies, T.G, Donald, A, McHardy, T, Rowlands, M.G, Hunter, L.J, Boyle, R.G, Aherne, G.W, Garrett, M.D, Collins, I. Deposit date: 2007-03-15 Release date: 2007-05-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B Through Structure-Based Design J.Med.Chem., 50, 2007
2UW8	Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine Descriptor: (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... Authors: Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A. Deposit date: 2007-03-19 Release date: 2007-05-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery. J.Med.Chem., 50, 2007
1Q1P	E-Cadherin activation Descriptor: CALCIUM ION, Epithelial-cadherin Authors: Haussinger, D, Stetefeld, J. Deposit date: 2003-07-22 Release date: 2004-04-20 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography. Embo J., 23, 2004
2UW3	Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole Descriptor: 3-METHYL-4-PHENYL-1H-PYRAZOLE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... Authors: Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A. Deposit date: 2007-03-19 Release date: 2007-05-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery J.Med.Chem., 50, 2007
2UVY	Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine Descriptor: CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, ... Authors: Davies, T.G, Donald, A, McHardy, T, Rowlands, M.G, Hunter, L.J, Boyle, R.G, Aherne, G.W, Garrett, M.D, Collins, I. Deposit date: 2007-03-15 Release date: 2007-05-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B Through Structure-Based Design J.Med.Chem., 50, 2007
2WP8	yeast rrp44 nuclease Descriptor: CHLORIDE ION, EXOSOME COMPLEX COMPONENT RRP45, EXOSOME COMPLEX COMPONENT SKI6, ... Authors: Basquin, J, Bonneau, F, Ebert, J, Lorentzen, E, Conti, E. Deposit date: 2009-08-03 Release date: 2009-11-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation. Cell(Cambridge,Mass.), 139, 2009
1NLV	Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, CALCIUM ION, ... Authors: Vorobiev, S.M, Welti, S, Condeelis, J, Almo, S.C. Deposit date: 2003-01-07 Release date: 2003-01-21 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Structure of Non-Vertebrate Actin: Implications For The ATP Hydrolytic Mechanism Proc.Natl.Acad.Sci.USA, 100, 2003
2WJX	Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution Descriptor: GLUTAMATE RECEPTOR 2 Authors: Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. Deposit date: 2009-06-01 Release date: 2009-08-18 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (4.1 Å) Cite: Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
2WJV	Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 Descriptor: REGULATOR OF NONSENSE TRANSCRIPTS 1, REGULATOR OF NONSENSE TRANSCRIPTS 2, SULFATE ION, ... Authors: Clerici, M, Mourao, A, Gutsche, I, Gehring, N.H, Hentze, M.W, Kulozik, A, Kadlec, J, Sattler, M, Cusack, S. Deposit date: 2009-06-01 Release date: 2009-07-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2. Embo J., 28, 2009
1QAG	Actin binding region of the dystrophin homologue utrophin Descriptor: UTROPHIN ACTIN BINDING REGION Authors: Keep, N.H, Winder, S.J, Moores, C.A, Walke, S, Norwood, F.L.M, Kendrick-Jones, J. Deposit date: 1999-03-05 Release date: 2000-01-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer Structure Fold.Des., 7, 1999
2WY1	Crystal structure of rat angiotensinogen in P321 space group Descriptor: ANGIOTENSINOGEN Authors: Zhou, A, Wei, Z, Carrell, R.W, Read, R.J. Deposit date: 2009-11-11 Release date: 2010-10-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.15 Å) Cite: A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature, 468, 2010
2WXW	Crystal structure of human angiotensinogen Descriptor: ANGIOTENSINOGEN Authors: Zhou, A, Wei, Z, Carrell, R.W, Read, R.J. Deposit date: 2009-11-11 Release date: 2010-10-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3.3 Å) Cite: A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature, 468, 2010
1Q96	Crystal structure of a mutant of the sarcin/ricin domain from rat 28S rRNA Descriptor: SULFATE ION, sarcin/ricin 28S rRNA Authors: Correll, C.C, Beneken, J, Plantinga, M.J, Lubbers, M, Chan, Y.L. Deposit date: 2003-08-22 Release date: 2003-11-25 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The common and distinctive features of the bulged-G motif based on a 1.04 A resolution RNA structure Nucleic Acids Res., 31, 2003
1QD7	PARTIAL MODEL FOR 30S RIBOSOMAL SUBUNIT Descriptor: CENTRAL FRAGMENT OF 16 S RNA, END FRAGMENT OF 16 S RNA, S15 RIBOSOMAL PROTEIN, ... Authors: Clemons Jr, W.M, May, J.L.C, Wimberly, B.T, McCutcheon, J.P, Capel, M.S, Ramakrishnan, V. Deposit date: 1999-07-09 Release date: 1999-08-31 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (5.5 Å) Cite: Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution. Nature, 400, 1999
2WWY	Structure of human RECQ-like helicase in complex with a DNA substrate Descriptor: 1,2-ETHANEDIOL, 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3', ATP-DEPENDENT DNA HELICASE Q1, ... Authors: Pike, A.C.W, Zhang, Y, Schnecke, C, Chaikuad, A, Krojer, T, Cooper, C.D.O, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2009-10-30 Release date: 2009-12-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures Proc.Natl.Acad.Sci.USA, 112, 2015

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