8EAE

Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI

Summary for 8EAE

• Entry DOI: 10.2210/pdb8eae/pdb
• Descriptor: Cyclic GMP-AMP synthase, Palindromic DNA18, [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (6 entities in total)
• Functional Keywords: transferase-dna complex, cgas, pppg(2, 5)pi, immune system, transferase/dna
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 109225.09

Authors

Wu, S.,Sohn, J. (deposition date: 2022-08-29, release date: 2023-10-25, Last modification date: 2024-05-29)

• Primary citation: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.; Nat Commun, 15:4012-4012, 2024; PubMed: 38740774; DOI: 10.1038/s41467-024-48365-3

Experimental method

X-RAY DIFFRACTION (2.56 Å)