6Z1C
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![BU of 6z1c by Molmil](/molmil-images/mine/6z1c) | Crystal structure of Arabidopsis thaliana CK2-alpha-1 in complex with TTP-22 | Descriptor: | 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha-1 | Authors: | Demulder, M, Loris, R, De Veylder, L. | Deposit date: | 2020-05-13 | Release date: | 2021-03-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway. Plant Cell, 33, 2021
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6WZG
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![BU of 6wzg by Molmil](/molmil-images/mine/6wzg) | Human secretin receptor Gs complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Piper, S.J, Belousoff, M.J, Danev, R. | Deposit date: | 2020-05-13 | Release date: | 2020-08-12 | Last modified: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
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6Z1E
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![BU of 6z1e by Molmil](/molmil-images/mine/6z1e) | |
6Z1D
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![BU of 6z1d by Molmil](/molmil-images/mine/6z1d) | |
6Z1F
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![BU of 6z1f by Molmil](/molmil-images/mine/6z1f) | CryoEM structure of Rubisco Activase with its substrate Rubisco from Nostoc sp. (strain PCC7120) | Descriptor: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wang, H, Bracher, A, Flecken, M, Popilka, L, Hartl, F.U, Hayer-Hartl, M. | Deposit date: | 2020-05-13 | Release date: | 2020-09-23 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes. Cell, 183, 2020
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7C3F
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![BU of 7c3f by Molmil](/molmil-images/mine/7c3f) | Crystal structure of ferredoxin: thioredoxin reductase and thioredoxin m2 complex | Descriptor: | Ferredoxin-thioredoxin reductase catalytic chain, chloroplastic, Ferredoxin-thioredoxin reductase variable chain, ... | Authors: | Kurisu, G, Juniar, L, Tanaka, H. | Deposit date: | 2020-05-12 | Release date: | 2020-10-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3986 Å) | Cite: | Structural basis for thioredoxin isoform-based fine-tuning of ferredoxin-thioredoxin reductase activity. Protein Sci., 29, 2020
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6WXU
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![BU of 6wxu by Molmil](/molmil-images/mine/6wxu) | CryoEM structure of mouse DUOX1-DUOXA1 complex in the dimer-of-dimer state | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | Authors: | Sun, J. | Deposit date: | 2020-05-12 | Release date: | 2020-09-02 | Last modified: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. Nat.Struct.Mol.Biol., 27, 2020
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7C3G
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![BU of 7c3g by Molmil](/molmil-images/mine/7c3g) | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a bicyclic pyrazole inhibitor RK-73134 | Descriptor: | 1,2-ETHANEDIOL, Activin receptor type-1, SULFATE ION, ... | Authors: | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | Deposit date: | 2020-05-12 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva. Bioorg.Med.Chem.Lett., 38, 2021
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6WXV
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![BU of 6wxv by Molmil](/molmil-images/mine/6wxv) | CryoEM structure of mouse DUOX1-DUOXA1 complex in the presence of NADPH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | Authors: | Sun, J. | Deposit date: | 2020-05-12 | Release date: | 2020-09-02 | Last modified: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. Nat.Struct.Mol.Biol., 27, 2020
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6WYC
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6WXR
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![BU of 6wxr by Molmil](/molmil-images/mine/6wxr) | CryoEM structure of mouse DUOX1-DUOXA1 complex in the absence of NADPH | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dual oxidase 1, Dual oxidase maturation factor 1, ... | Authors: | Sun, J. | Deposit date: | 2020-05-11 | Release date: | 2020-09-02 | Last modified: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation. Nat.Struct.Mol.Biol., 27, 2020
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7C36
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![BU of 7c36 by Molmil](/molmil-images/mine/7c36) | c-Myc DNA binding protein structure | Descriptor: | RNA-binding motif, single-stranded-interacting protein 1 | Authors: | Aggarwal, P, Bhavesh, N.S. | Deposit date: | 2020-05-11 | Release date: | 2021-05-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter. Nucleic Acids Res., 49, 2021
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6Z10
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![BU of 6z10 by Molmil](/molmil-images/mine/6z10) | Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, CHLORIDE ION, ... | Authors: | Haffke, M, Villard, F. | Deposit date: | 2020-05-11 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.269 Å) | Cite: | Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J.Med.Chem., 63, 2020
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6WX5
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![BU of 6wx5 by Molmil](/molmil-images/mine/6wx5) | Adducts formed after 3 weeks in the reaction of chlorido[chlorido(2,2'-((2-([2,2':6',2''-Terpyridin]-4'-yloxy)ethyl)azanediyl)bis(ethan-1-ol))platinum(II)] with HEWL | Descriptor: | ACETATE ION, Lysozyme, PLATINUM (II) ION, ... | Authors: | Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. | Deposit date: | 2020-05-09 | Release date: | 2021-02-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Mustards-Derived Terpyridine-Platinum Complexes as Anticancer Agents: DNA Alkylation vs Coordination. Inorg.Chem., 60, 2021
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6WWV
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![BU of 6wwv by Molmil](/molmil-images/mine/6wwv) | KIF14[391-735] - ANP-PNP in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWJ
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![BU of 6wwj by Molmil](/molmil-images/mine/6wwj) | KIF14[391-755] - ADP in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWF
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![BU of 6wwf by Molmil](/molmil-images/mine/6wwf) | KIF14[391-772] - ADP in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWM
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![BU of 6wwm by Molmil](/molmil-images/mine/6wwm) | KIF14[391-748] - ADP in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWE
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![BU of 6wwe by Molmil](/molmil-images/mine/6wwe) | Apo KIF14[391-772] in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWN
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![BU of 6wwn by Molmil](/molmil-images/mine/6wwn) | KIF14[391-748] - ADP-AlFx in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWI
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![BU of 6wwi by Molmil](/molmil-images/mine/6wwi) | Apo KIF14[391-755] in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWO
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![BU of 6wwo by Molmil](/molmil-images/mine/6wwo) | KIF14[391-748] - AMP-PNP in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWS
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![BU of 6wws by Molmil](/molmil-images/mine/6wws) | Kif14[391-743] - AMP-PNP open state class in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWR
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![BU of 6wwr by Molmil](/molmil-images/mine/6wwr) | Kif14[391-743] - ADP-AlFx open state class in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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6WWP
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![BU of 6wwp by Molmil](/molmil-images/mine/6wwp) | Apo KIF14[391-743] in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF14, ... | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Paydar, M, Dhakal, S, Kwok, B, Sosa, H. | Deposit date: | 2020-05-09 | Release date: | 2021-05-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14. Nat Commun, 12, 2021
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