6WXU

CryoEM structure of mouse DUOX1-DUOXA1 complex in the dimer-of-dimer state

Summary for 6WXU

• Entry DOI: 10.2210/pdb6wxu/pdb
• EMDB information: 21963
• Descriptor: Dual oxidase 1, Dual oxidase maturation factor 1, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: membrane protein, protein complex, nadph oxidase, ros production
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 437489.54

Authors

Sun, J. (deposition date: 2020-05-12, release date: 2020-09-02, Last modification date: 2021-03-17)

• Primary citation: Sun, J.; Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.; Nat.Struct.Mol.Biol., 27:1086-1093, 2020; PubMed: 32929281; DOI: 10.1038/s41594-020-0501-x

Experimental method

ELECTRON MICROSCOPY (2.7 Å)