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6WXU

CryoEM structure of mouse DUOX1-DUOXA1 complex in the dimer-of-dimer state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005509molecular_functioncalcium ion binding
A0006979biological_processresponse to oxidative stress
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
B0005515molecular_functionprotein binding
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0008104biological_processprotein localization
B0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0042743biological_processhydrogen peroxide metabolic process
B0045666biological_processpositive regulation of neuron differentiation
B0050727biological_processregulation of inflammatory response
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
B2000609biological_processregulation of thyroid hormone generation
C0004601molecular_functionperoxidase activity
C0005509molecular_functioncalcium ion binding
C0006979biological_processresponse to oxidative stress
C0016491molecular_functionoxidoreductase activity
C0020037molecular_functionheme binding
D0005515molecular_functionprotein binding
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0008104biological_processprotein localization
D0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0042743biological_processhydrogen peroxide metabolic process
D0045666biological_processpositive regulation of neuron differentiation
D0050727biological_processregulation of inflammatory response
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
D2000609biological_processregulation of thyroid hormone generation
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGNGYLSfrEF
ChainResidueDetails
AASP828-PHE840
AASP864-PHE876

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues310
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BMET1-LEU24
BSER73-MET183
BTHR227-PRO249
DMET1-LEU24
DSER73-MET183
DTHR227-PRO249

site_idSWS_FT_FI2
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BALA25-ILE45
DALA250-VAL270
BPHE52-PHE72
BLEU184-VAL204
BGLY206-MET226
BALA250-VAL270
DALA25-ILE45
DPHE52-PHE72
DLEU184-VAL204
DGLY206-MET226

site_idSWS_FT_FI3
Number of Residues152
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BARG46-LEU51
BTYR205
BALA271-LEU341
DARG46-LEU51
DTYR205
DALA271-LEU341

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN84
BASN109
BASN121
DASN84
DASN109
DASN121

223532

PDB entries from 2024-08-07

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