6WXU
CryoEM structure of mouse DUOX1-DUOXA1 complex in the dimer-of-dimer state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Dual oxidase 1 | polymer | 1536 | 175739.8 | 2 | UniProt (A2AQ92) Pfam (PF03098) Pfam (PF00036) Pfam (PF13499) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) In PDB | Mus musculus (Mouse) | |
| 2 | B, D | Dual oxidase maturation factor 1 | polymer | 341 | 37619.7 | 2 | UniProt (Q8VE49) Pfam (PF10204) In PDB | Mus musculus (Mouse) | Dual oxidase activator 1 |
| 3 | E, F | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 2 | In PDB GlyTouCan (G60230HH) | |||
| 4 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 5 | A, C | HEME C | non-polymer | 618.5 | 4 | Chemie (HEC) | |||
| 6 | A, C | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE | non-polymer | 535.7 | 2 | Chemie (PX2) | |||
| 7 | B, D | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 2 | Chemie (PLC) |
Sequence modifications
A, C: 20 - 1551 (UniProt: A2AQ92)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Arg 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 426719.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3767.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 7003.1 | |
| All* | Total formula weight | 437489.5 |
