7OXA
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![BU of 7oxa by Molmil](/molmil-images/mine/7oxa) | Target-bound SpCas9 complex with AAVS1 chimeric RNA-DNA guide | Descriptor: | AAVS1 non-target DNA strand, AAVS1 target DNA strand, CRISPR-associated endonuclease Cas9/Csn1, ... | Authors: | Donohoue, P, Pacesa, M, Lau, E, Vidal, B, Irby, M.J, Nyer, D.B, Rotstein, T, Banh, L, Toh, M.T, Gibson, J, Kohrs, B, Baek, K, Owen, A.L.G, Slorach, E.M, van Overbeek, M, Fuller, C.K, May, A.P, Jinek, M, Cameron, P. | Deposit date: | 2021-06-22 | Release date: | 2021-09-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells. Mol.Cell, 81, 2021
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7OX7
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![BU of 7ox7 by Molmil](/molmil-images/mine/7ox7) | Target-bound SpCas9 complex with TRAC chimeric RNA-DNA guide | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Donohoue, P, Pacesa, M, Lau, E, Vidal, B, Irby, M.J, Nyer, D.B, Rotstein, T, Banh, L, Toh, M.T, Gibson, J, Kohrs, B, Baek, K, Owen, A.L.G, Slorach, E.M, van Overbeek, M, Fuller, C.K, May, A.P, Jinek, M, Cameron, P. | Deposit date: | 2021-06-22 | Release date: | 2021-09-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells. Mol.Cell, 81, 2021
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5H82
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![BU of 5h82 by Molmil](/molmil-images/mine/5h82) | HETEROYOHIMBINE SYNTHASE THAS2 FROM CATHARANTHUS ROSEUS - APO FORM | Descriptor: | ZINC ION, heteroyohimbine synthase THAS2 | Authors: | Stavrinides, A, Tatsis, E.C, Caputi, L, Foureau, E, Stevenson, C.E.M, Lawson, D.M, Courdavault, V, O'Connor, S.E. | Deposit date: | 2015-12-23 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nat Commun, 7, 2016
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8TKN
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![BU of 8tkn by Molmil](/molmil-images/mine/8tkn) | Murine NF-kappaB p50 Rel Homology Region homodimer in complex with 10-mer kappaB DNA from human Neutrophil Gelatinase-associated Lipocalin (NGAL) promoter | Descriptor: | DNA A, DNA B, Nuclear factor NF-kappa-B p50 subunit | Authors: | Zhu, N, Mealka, M, Mitchel, S, Rogers, W.E, Huxford, T. | Deposit date: | 2023-07-25 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray Crystallographic Study of Preferred Spacing by the NF-kappa B p50 Homodimer on kappa B DNA. Biomolecules, 13, 2023
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8EGW
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![BU of 8egw by Molmil](/molmil-images/mine/8egw) | Complex of Fat4(EC1-4) bound to Dchs1(EC1-3) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Medina, E, Luca, V.C. | Deposit date: | 2022-09-13 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the planar cell polarity cadherins Fat4 and Dachsous1. Nat Commun, 14, 2023
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6Z9X
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![BU of 6z9x by Molmil](/molmil-images/mine/6z9x) | Human Class I Major Histocompatibility Complex, A02 allele, presenting LLS (t-butyl)Y FGTPT | Descriptor: | Beta-2-microglobulin, LEU-LEU-SER-TUR-PHE-GLY-THR-PRO-THR, MHC class I antigen, ... | Authors: | Rizkallah, P.J, Man, S, Redman, J.E. | Deposit date: | 2020-06-04 | Release date: | 2021-06-30 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells. J Immunol., 207, 2021
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8G6D
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![BU of 8g6d by Molmil](/molmil-images/mine/8g6d) | |
8EXH
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![BU of 8exh by Molmil](/molmil-images/mine/8exh) | Agrobacterium tumefaciens Tpilus | Descriptor: | (14S,17R)-20-amino-17-hydroxy-11,17-dioxo-12,16,18-trioxa-17lambda~5~-phosphaicosan-14-yl tetradecanoate, Protein virB2 | Authors: | Beltran, L.C, Egelman, E.H. | Deposit date: | 2022-10-25 | Release date: | 2023-03-22 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery Nat Commun, 14, 2023
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6WR1
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![BU of 6wr1 by Molmil](/molmil-images/mine/6wr1) | Human steroidogenic cytochrome P450 17A1 mutant N52Y with inhibitor abiraterone | Descriptor: | Abiraterone, PROTOPORPHYRIN IX CONTAINING FE, Steroid 17-alpha-hydroxylase/17,20 lyase | Authors: | Petrunak, E.M, Bart, A.G, Scott, E.E. | Deposit date: | 2020-04-29 | Release date: | 2021-05-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
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6WR0
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![BU of 6wr0 by Molmil](/molmil-images/mine/6wr0) | Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog | Descriptor: | (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Petrunak, E.M, Bart, A.G, Scott, E.E. | Deposit date: | 2020-04-29 | Release date: | 2021-05-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
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6WW0
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![BU of 6ww0 by Molmil](/molmil-images/mine/6ww0) | Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog | Descriptor: | (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Petrunak, E.M, Bart, A.G, Scott, E.E. | Deposit date: | 2020-05-07 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
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7P5X
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![BU of 7p5x by Molmil](/molmil-images/mine/7p5x) | Mycobacterial RNAP with transcriptional activator PafBC | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | Deposit date: | 2021-07-15 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
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6OF8
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![BU of 6of8 by Molmil](/molmil-images/mine/6of8) | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha, GLYCEROL, POTASSIUM ION | Authors: | McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. | Deposit date: | 2019-03-28 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/calmodulin-dependent protein kinase II. Protein Sci., 28, 2019
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7P6M
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![BU of 7p6m by Molmil](/molmil-images/mine/7p6m) | Hydrogenated refolded hen egg-white lysozyme | Descriptor: | ACETATE ION, Lysozyme C, NITRATE ION | Authors: | Ramos, J, Laux, V, Haertlein, M, Forsyth, V.T, Mossou, E, Larsen, S, Langkilde, A.E. | Deposit date: | 2021-07-16 | Release date: | 2021-12-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (0.89 Å) | Cite: | The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme. Acta Crystallogr D Struct Biol, 77, 2021
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8EUJ
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![BU of 8euj by Molmil](/molmil-images/mine/8euj) | Class2 of the INO80-Nucleosome complex | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Wu, H, Munoz, E, Gourdet, M, Narlikar, G, Cheng, Y.F. | Deposit date: | 2022-10-18 | Release date: | 2023-07-12 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
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8CII
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![BU of 8cii by Molmil](/molmil-images/mine/8cii) | Delta-RBD complex with BA.2-07 fab, SARS1-34 fab and C1 nanobody | Descriptor: | BA.2-07 fab Heavy Chain, BA.2-07 fab Light Chain, C1 nanobody, ... | Authors: | Duyvesteyn, H.M.E, Ren, J, Stuart, D.I, Fry, E.E. | Deposit date: | 2023-02-09 | Release date: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Potent cross-reactive mAbs from BA.4/5 breakthrough infection To Be Published
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8ETT
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![BU of 8ett by Molmil](/molmil-images/mine/8ett) | Class1 of the INO80-Hexasome complex | Descriptor: | DNA (110-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. | Deposit date: | 2022-10-17 | Release date: | 2023-07-12 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (6.68 Å) | Cite: | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
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8ETV
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![BU of 8etv by Molmil](/molmil-images/mine/8etv) | Class2 of the INO80-Hexasome complex | Descriptor: | DNA (110-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. | Deposit date: | 2022-10-17 | Release date: | 2023-07-12 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
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8EU2
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![BU of 8eu2 by Molmil](/molmil-images/mine/8eu2) | Class3 of the INO80-Hexasome complex | Descriptor: | DNA (110-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. | Deposit date: | 2022-10-18 | Release date: | 2023-07-12 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
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8SWF
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![BU of 8swf by Molmil](/molmil-images/mine/8swf) | Cryo-EM structure of NLRP3 open octamer | Descriptor: | NACHT, LRR and PYD domains-containing protein 3 | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-18 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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8EUE
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![BU of 8eue by Molmil](/molmil-images/mine/8eue) | Class1 of the INO80-Nucleosome complex | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Wu, H, Munoz, E, Gourdet, M, Narlikar, G, Cheng, Y.F. | Deposit date: | 2022-10-18 | Release date: | 2023-07-12 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
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8F28
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![BU of 8f28 by Molmil](/molmil-images/mine/8f28) | Lysozyme Structures from Single-Entity Crystallization Method NanoAC | Descriptor: | ACETATE ION, CHLORIDE ION, Lysozyme C, ... | Authors: | Yang, R, Sankaran, B, Ogbonna, E, Wang, G. | Deposit date: | 2022-11-07 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | A Single-Entity Method for Actively Controlled Nucleation and High-Quality Protein Crystal Synthesis. Anal.Chem., 95, 2023
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4X8A
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![BU of 4x8a by Molmil](/molmil-images/mine/4x8a) | NavMS pore and C-terminal domain grown from protein purified in LiCl | Descriptor: | HEGA-10, Ion transport protein, NONAETHYLENE GLYCOL, ... | Authors: | Naylor, C.E, Bagneris, C, Wallace, B.A. | Deposit date: | 2014-12-10 | Release date: | 2016-03-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Molecular basis of ion permeability in a voltage-gated sodium channel. Embo J., 35, 2016
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8EOH
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![BU of 8eoh by Molmil](/molmil-images/mine/8eoh) | crystal structure of human Cytochrome P450 8B1 in complex with a C12-Pyridine Containing Steroid | Descriptor: | 12-(pyridin-3-yl)-8alpha,10alpha,13alpha,14beta-androsta-4,11-diene-3,17-dione, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Liu, J, Scott, E.E. | Deposit date: | 2022-10-03 | Release date: | 2023-08-02 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281. J.Biol.Chem., 299, 2023
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6XT7
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![BU of 6xt7 by Molmil](/molmil-images/mine/6xt7) | Tel25 Hybrid Four-quartet G-quadruplex with K+ | Descriptor: | DNA (25-MER), MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Yatsunyk, L.A, McCarthy, S.E. | Deposit date: | 2020-07-17 | Release date: | 2020-12-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | The first crystal structures of hybrid and parallel four-tetrad intramolecular G-quadruplexes. Nucleic Acids Res., 50, 2022
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