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6WW0

Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog

Summary for 6WW0
Entry DOI10.2210/pdb6ww0/pdb
DescriptorSteroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one, ... (5 entities in total)
Functional Keywordscytochrome p450, p450, 17a1, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight226895.45
Authors
Petrunak, E.M.,Bart, A.G.,Scott, E.E. (deposition date: 2020-05-07, release date: 2021-05-26, Last modification date: 2023-10-18)
Primary citationPetrunak, E.M.,Bart, A.G.,Peng, H.M.,Auchus, R.J.,Scott, E.E.
Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
J.Biol.Chem., 299:102999-102999, 2023
Cited by
PubMed: 36773804
DOI: 10.1016/j.jbc.2023.102999
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.01 Å)
Structure validation

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