8SWF

Cryo-EM structure of NLRP3 open octamer

Summary for 8SWF

• Entry DOI: 10.2210/pdb8swf/pdb
• EMDB information: 40811
• Descriptor: NACHT, LRR and PYD domains-containing protein 3 (1 entity in total)
• Functional Keywords: activated nlrp3, cryo-em, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 829405.94

Authors

Yu, X.,Matico, R.E.,Miller, R.,Schoubroeck, B.V.,Grauwen, K.,Suarez, J.,Pietrak, B.,Haloi, N.,Yin, Y.,Tresadern, G.J.,Perez-Benito, L.,Lindahl, E.,Bottelbergs, A.,Oehlrich, D.,Opdenbosch, N.V.,Sharma, S. (deposition date: 2023-05-18, release date: 2024-02-14)

• Primary citation: Yu, X.,Matico, R.E.,Miller, R.,Schoubroeck, B.V.,Grauwen, K.,Suarez, J.,Pietrak, B.,Haloi, N.,Yin, Y.,Tresadern, G.J.,Perez-Benito, L.,Lindahl, E.,Bottelbergs, A.,Oehlrich, D.,Opdenbosch, N.V.,Sharma, S.; Cryo-EM structures of NLRP3 reveal its self-activation mechanism; Nat Commun, 2024

Experimental method

ELECTRON MICROSCOPY (3.39 Å)