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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8SWF

Cryo-EM structure of NLRP3 open octamer

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:35254907, ECO:0000305\|PubMed:36142182, ECO:0000305\|PubMed:36442502, ECO:0007744\|PDB:7VTP, ECO:0007744\|PDB:7ZGU, ECO:0007744\|PDB:8EJ4

Chain	Residue	Details
A	THR169
B	THR169
C	THR169
D	THR169
E	THR169
F	THR169
G	THR169
H	THR169

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00136, ECO:0000269\|PubMed:17483456, ECO:0000305\|PubMed:34687713, ECO:0000305\|PubMed:35114687, ECO:0000305\|PubMed:35254907, ECO:0000305\|PubMed:36142182, ECO:0000305\|PubMed:36442502, ECO:0007744\|PDB:7ALV, ECO:0007744\|PDB:7PZC, ECO:0007744\|PDB:7VTP, ECO:0007744\|PDB:7ZGU, ECO:0007744\|PDB:8EJ4

Chain	Residue	Details
A	GLY226
B	GLY226
C	GLY226
D	GLY226
E	GLY226
F	GLY226
G	GLY226
H	GLY226

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305\|PubMed:34687713, ECO:0000305\|PubMed:35114687, ECO:0000305\|PubMed:35254907, ECO:0000305\|PubMed:36142182, ECO:0007744\|PDB:7ALV, ECO:0007744\|PDB:7PZC, ECO:0007744\|PDB:7VTP, ECO:0007744\|PDB:7ZGU

Chain	Residue	Details
A	HIS522
B	HIS522
C	HIS522
D	HIS522
E	HIS522
F	HIS522
G	HIS522
H	HIS522

site_id	SWS_FT_FI4
Number of Residues	32
Details	MOD_RES: Phosphotyrosine; by BTK => ECO:0000269\|PubMed:34554188

Chain	Residue	Details
A	TYR136
C	TYR140
C	TYR143
C	TYR168
D	TYR136
D	TYR140
D	TYR143
D	TYR168
E	TYR136
E	TYR140
E	TYR143
A	TYR140
E	TYR168
F	TYR136
F	TYR140
F	TYR143
F	TYR168
G	TYR136
G	TYR140
G	TYR143
G	TYR168
H	TYR136
A	TYR143
H	TYR140
H	TYR143
H	TYR168
A	TYR168
B	TYR136
B	TYR140
B	TYR143
B	TYR168
C	TYR136

site_id	SWS_FT_FI5
Number of Residues	16
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q8R4B8

Chain	Residue	Details
A	SER161
E	SER295
F	SER161
F	SER295
G	SER161
G	SER295
H	SER161
H	SER295
A	SER295
B	SER161
B	SER295
C	SER161
C	SER295
D	SER161
D	SER295
E	SER161

site_id	SWS_FT_FI6
Number of Residues	32
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:28943315

Chain	Residue	Details
A	SER163
C	SER334
C	SER728
C	SER975
D	SER163
D	SER334
D	SER728
D	SER975
E	SER163
E	SER334
E	SER728
A	SER334
E	SER975
F	SER163
F	SER334
F	SER728
F	SER975
G	SER163
G	SER334
G	SER728
G	SER975
H	SER163
A	SER728
H	SER334
H	SER728
H	SER975
A	SER975
B	SER163
B	SER334
B	SER728
B	SER975
C	SER163

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:35114687

Chain	Residue	Details
A	SER198
B	SER198
C	SER198
D	SER198
E	SER198
F	SER198
G	SER198
H	SER198

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:35114687

Chain	Residue	Details
A	SER201
B	SER201
C	SER201
D	SER201
E	SER201
F	SER201
G	SER201
H	SER201

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: Phosphoserine; by LATS1 and LATS2 => ECO:0000269\|PubMed:39173637

Chain	Residue	Details
A	SER265
B	SER265
C	SER265
D	SER265
E	SER265
F	SER265
G	SER265
H	SER265

site_id	SWS_FT_FI10
Number of Residues	24
Details	MOD_RES: Phosphoserine; by CSNK1A1 => ECO:0000269\|PubMed:34615873

Chain	Residue	Details
A	SER735
D	SER735
D	SER806
D	SER1035
E	SER735
E	SER806
E	SER1035
F	SER735
F	SER806
F	SER1035
G	SER735
A	SER806
G	SER806
G	SER1035
H	SER735
H	SER806
H	SER1035
A	SER1035
B	SER735
B	SER806
B	SER1035
C	SER735
C	SER806
C	SER1035

site_id	SWS_FT_FI11
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:27043286

Chain	Residue	Details
A	TYR861
B	TYR861
C	TYR861
D	TYR861
E	TYR861
F	TYR861
G	TYR861
H	TYR861

site_id	SWS_FT_FI12
Number of Residues	16
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:39173637

Chain	Residue	Details
A	CYS130
E	CYS958
F	CYS130
F	CYS958
G	CYS130
G	CYS958
H	CYS130
H	CYS958
A	CYS958
B	CYS130
B	CYS958
C	CYS130
C	CYS958
D	CYS130
D	CYS958
E	CYS130

site_id	SWS_FT_FI13
Number of Residues	24
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:36586411

Chain	Residue	Details
A	CYS837
D	CYS837
D	CYS838
D	CYS844
E	CYS837
E	CYS838
E	CYS844
F	CYS837
F	CYS838
F	CYS844
G	CYS837
A	CYS838
G	CYS838
G	CYS844
H	CYS837
H	CYS838
H	CYS844
A	CYS844
B	CYS837
B	CYS838
B	CYS844
C	CYS837
C	CYS838
C	CYS844

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:26037928

Chain	Residue	Details
A	LYS689
B	LYS689
C	LYS689
D	LYS689
E	LYS689
F	LYS689
G	LYS689
H	LYS689

site_id	SWS_FT_FI15
Number of Residues	32
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:34615873

Chain	Residue	Details
C	LYS878
C	LYS927
C	LYS973
D	LYS878
D	LYS927
D	LYS973
E	LYS878
E	LYS927
A	LYS878
E	LYS973
F	LYS878
F	LYS927
F	LYS973
G	LYS878
G	LYS927
G	LYS973
A	LYS927
H	LYS878
H	LYS927
H	LYS973
A	LYS973
B	LYS878
B	LYS927
B	LYS973

237423

PDB entries from 2025-06-11

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