PDB: 255 件ウェブページステータス検索Chemie searchBIRD

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6GWN	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) 分子名称: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64 著者 Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2018-06-25 公開日 2020-01-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
6GWQ	Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42) 分子名称: Plasminogen Activator Inhibitor-1, VHH-2g-42 著者 Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2018-06-25 公開日 2020-01-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
5ZLZ	Structure of tPA and PAI-1 分子名称: GLYCEROL, Plasminogen activator inhibitor 1, Tissue-type plasminogen activator 著者 Min, L, Huang, M. 登録日 2018-03-31 公開日 2019-04-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.581 Å) 主引用文献 Development of a PAI-1 trapping agent (PAItrap2) based on inactivated tPA-SPD and the crystal structure of PAItrap2 in complex with PAI-1 To Be Published
6CJ7	Crystal structure of Manduca sexta Serine protease inhibitor (Serpin)-12 分子名称: Serpin-12 著者 Gulati, M, Hu, Y, Peng, S, Pathak, P.K, Wang, Y, Deng, J, Jiang, H. 登録日 2018-02-26 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Manduca sexta serpin-12 controls the prophenoloxidase activation system in larval hemolymph. Insect Biochem. Mol. Biol., 99, 2018
6FTP	Crystal form 1 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated drug-binding serpin for doxorubicin 分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, DOXORUBICIN 著者 Schmidt, K, Muller, Y.A. 登録日 2018-02-22 公開日 2018-05-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6F4V	Crystal structure of cleaved Kallistatin complexed with heparin at 1.8 Angstrom resolution 分子名称: 1,2-ETHANEDIOL, 3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, CHLORIDE ION, ... 著者 Zhou, A, Wei, Z. 登録日 2017-11-30 公開日 2018-12-12 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of human Kallistatin To Be Published
6F4U	Crystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolution 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... 著者 Zhou, A, Wei, Z, Lin, F. 登録日 2017-11-30 公開日 2018-12-12 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of human Kallistatin To Be Published
6F02	Crystal structure of human glycosylated kallistatin at 3.0 Angstrom resolution 分子名称: Kallistatin, SULFATE ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhou, A, Ma, L. 登録日 2017-11-17 公開日 2018-12-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of human Kallistatin To Be Published
6BJ5	Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1) 分子名称: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Mahon, B.P, Lomelino, C.L, McKenna, R. 登録日 2017-11-05 公開日 2018-11-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1) To Be Published
5OM5	Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo1: an allosterically triggered drug-binding serpin for doxycycline 分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CHLORIDE ION 著者 Schmidt, K, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (1.595 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM3	Crystal structure of Alpha1-antichymotrypsin variant DBS-I5: a MMP14-cleavable drug-binding serpin for doxycycline 分子名称: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, Alpha-1-antichymotrypsin, DI(HYDROXYETHYL)ETHER 著者 Schmidt, K, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM8	Crystal form 2 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated drug-binding serpin for doxorubicin 分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CHLORIDE ION, ... 著者 Schmidt, K, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM2	Crystal structure of Alpha1-antichymotrypsin variant DBS-I1: a drug-binding serpin for doxycycline 分子名称: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin 著者 Schmidt, K, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM7	Crystal structure of Alpha1-antichymotrypsin variant DBS-II: a drug-binding serpin for doxorubicin 分子名称: Alpha-1-antichymotrypsin, DOXORUBICIN 著者 Schmidt, K, Kern, A, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (1.727 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM6	Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo2: a MMP9-cleavable drug-binding serpin for doxycycline 分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CHLORIDE ION, ... 著者 Schmidt, K, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NCS	Structure of the native serpin-type proteinase inhibitor, miropin. 分子名称: Serpin 著者 Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. 登録日 2017-03-06 公開日 2017-05-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5NCU	Structure of the subtilisin induced serpin-type proteinase inhibitor, miropin. 分子名称: CHLORIDE ION, GLYCEROL, IODIDE ION, ... 著者 Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. 登録日 2017-03-06 公開日 2017-05-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5NCT	Structure of the trypsin induced serpin-type proteinase inhibitor, miropin. 分子名称: ASPARTIC ACID, GLYCEROL, SERINE, ... 著者 Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. 登録日 2017-03-06 公開日 2017-05-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5NCW	Structure of the trypsin induced serpin-type proteinase inhibitor, miropin (V367K/K368A mutant). 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... 著者 Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X. 登録日 2017-03-06 公開日 2017-05-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. J. Biol. Chem., 292, 2017
5NBU	Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations 分子名称: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID 著者 Huntington, J.A, Pomowski, A, Johnson, D.J.D. 登録日 2017-03-02 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION To Be Published
5NBV	Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations 分子名称: Alpha-1-antitrypsin, GLYCEROL 著者 Huntington, J.A, Pomowski, A, Johnson, D.J.D. 登録日 2017-03-02 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION To Be Published
5M3Y	Crystal structure of human glycosylated angiotensinogen 分子名称: Angiotensinogen, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Yan, Y, Read, R.J. 登録日 2016-10-17 公開日 2017-12-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
5M3X	Crystal structure of human angiotensin I-deleted angiotensinogen 分子名称: Angiotensinogen 著者 Yan, Y, Read, R.J. 登録日 2016-10-17 公開日 2017-12-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structural basis for the specificity of renin-mediated angiotensinogen cleavage. J. Biol. Chem., 294, 2019
5INW	Structure of reaction loop cleaved lamprey angiotensinogen 分子名称: C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION 著者 Wei, H, Zhou, A. 登録日 2016-03-08 公開日 2016-10-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism J.Biol.Chem., 291, 2016
5IO1	CRYSTAL STRUCTURE OF RECOMBINANT HUMAN Z ALPHA-1-ANTITRYPSIN 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-1-antitrypsin 著者 Zhou, A. 登録日 2016-03-08 公開日 2016-06-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Molecular Mechanism of Z alpha 1-Antitrypsin Deficiency J. Biol. Chem., 291, 2016

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