5IO1

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN Z ALPHA-1-ANTITRYPSIN

Summary for 5IO1

Entry DOI	10.2210/pdb5io1/pdb
Descriptor	Alpha-1-antitrypsin, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	serpins, acute phase, alternative splicing, blood coagulation, disease mutation, glycoprotein, hydrolase, polymorphism, protease, protease inhibitor, secreted, serine protease inhibitor, hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	90462.75
Authors	Zhou, A. (deposition date: 2016-03-08, release date: 2016-06-08, Last modification date: 2023-11-08)
Primary citation	Huang, X.,Zheng, Y.,Zhang, F.,Wei, Z.,Wang, Y.,Carrell, R.W.,Read, R.J.,Chen, G.Q.,Zhou, A. Molecular Mechanism of Z alpha 1-Antitrypsin Deficiency J. Biol. Chem., 291:15674-15686, 2016 Cited by PubMed: 27246852 DOI: 10.1074/jbc.M116.727826 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.34 Å)

Structure validation