5IO1

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN Z ALPHA-1-ANTITRYPSIN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha-1-antitrypsin	polymer	398	45010.2	2	UniProt (P01009) Pfam (PF00079)	Homo sapiens (Human)	Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Serpin A1
2	C, D (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
3	E, F (A, B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 5 - 394 (UniProt: P01009)

PDB	External Database	Details
Arg -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
Lys 342	Glu 366	engineered mutation
Cys 345	Thr 369	engineered mutation
Arg 358	Met 382	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90020.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	90462.8

*Water molecules are not included.