8F2I
 
 | | P53 monomer structure | | Descriptor: | Cellular tumor antigen p53 | | Authors: | Solares, M, Kelly, D.F. | | Deposit date: | 2022-11-08 | | Release date: | 2022-11-23 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.
Chembiochem, 23, 2022
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8F2H
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6X3T
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol | | Descriptor: | 2,6-BIS(1-METHYLETHYL)PHENOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | | Deposit date: | 2020-05-21 | | Release date: | 2020-09-09 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
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5ZFG
 | | Crystal structure of a diazinon-metabolizing glutathione S-transferase in the silkworm, Bombyx mori | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Glutathione S-transferase | | Authors: | Yamamoto, K, Higashiura, A, Nakagawa, A. | | Deposit date: | 2018-03-06 | | Release date: | 2018-09-12 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Characterisation of a diazinon-metabolising glutathione S-transferase in the silkworm Bombyx mori by X-ray crystallography and genome editing analysis.
Sci Rep, 8, 2018
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1L0L
 | | structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone | | Descriptor: | Cytochrome B, Cytochrome c1, heme protein, ... | | Authors: | Gao, X, Wen, X, Yu, C.A, Esser, L, Tsao, S, Quinn, B, Zhang, L, Yu, L, Xia, D. | | Deposit date: | 2002-02-11 | | Release date: | 2003-04-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Famoxadone: The Role of Aromatic-Aromatic Interaction in Inhibition
Biochemistry, 41, 2003
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6X3W
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ... | | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | | Deposit date: | 2020-05-21 | | Release date: | 2020-09-09 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
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6WQE
 | | Solution Structure of the IWP-051-bound H-NOX from Shewanella woodyi in the Fe(II)CO ligation state | | Descriptor: | 5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-ol, CARBON MONOXIDE, Heme NO binding domain protein, ... | | Authors: | Chen, C.Y, Lee, W, Montfort, W.R. | | Deposit date: | 2020-04-28 | | Release date: | 2020-07-22 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051.
Protein Sci., 30, 2021
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5ZK3
 | | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB | | Descriptor: | (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2 | | Authors: | Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T. | | Deposit date: | 2018-03-23 | | Release date: | 2018-11-21 | | Last modified: | 2022-03-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
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1KE3
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1KE6
 | | CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE | | Descriptor: | Cell division protein kinase 2, N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE | | Authors: | Bramson, H.N, Corona, J, Davis, S.T, Dickerson, S.H, Edelstein, M, Frye, S.V, Gampe, R.T, Hassell, A.H, Shewchuk, L.M, Kuyper, L.F. | | Deposit date: | 2001-11-14 | | Release date: | 2002-05-14 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
J.Med.Chem., 44, 2001
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6CK5
 | | PRPP riboswitch from T. mathranii bound to PRPP | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, BARIUM ION, MAGNESIUM ION, ... | | Authors: | Knappenberger, A.J, Reiss, C.W, Strobel, S.A. | | Deposit date: | 2018-02-27 | | Release date: | 2018-06-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA.
Elife, 7, 2018
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1L0N
 | | native structure of bovine mitochondrial cytochrome bc1 complex | | Descriptor: | Cytochrome B, Cytochrome c1, heme protein, ... | | Authors: | Gao, X, Wen, X, Yu, C.A, Esser, L, Tsao, S, Quinn, B, Zhang, L, Yu, L, Xia, D. | | Deposit date: | 2002-02-11 | | Release date: | 2003-04-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Famoxadone: The Role of Aromatic-Aromatic Interaction in Inhibition
Biochemistry, 41, 2003
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6GV0
 | | Insulin glulisine | | Descriptor: | FORMIC ACID, Insulin, ZINC ION | | Authors: | Chayen, N.E, Helliwell, J.R, Solomon-Gamsu, H.V, Govada, L, Morgan, M, Gillis, R.B, Adams, G. | | Deposit date: | 2018-06-20 | | Release date: | 2019-07-03 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques.
Sci Rep, 11, 2021
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6D3P
 | | Crystal structure of an exoribonuclease-resistant RNA from Sweet clover necrotic mosaic virus (SCNMV) | | Descriptor: | IRIDIUM HEXAMMINE ION, RNA (45-MER) | | Authors: | Steckelberg, A.-L, Akiyama, B.M, Costantino, D.A, Sit, T.L, Nix, J.C, Kieft, J.S. | | Deposit date: | 2018-04-16 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1IHI
 | | Crystal Structure of Human Type III 3-alpha-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein (AKR1C2) Complexed with NADP+ and Ursodeoxycholate | | Descriptor: | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, ISO-URSODEOXYCHOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Jin, Y, Stayrook, S.E, Albert, R.H, Palackal, N.T, Penning, T.M, Lewis, M. | | Deposit date: | 2001-04-19 | | Release date: | 2001-10-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
Biochemistry, 40, 2001
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3PYK
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3Q3U
 | | Trametes cervina lignin peroxidase | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Calvino, F.R, Romero, A, Miki, Y, Martinez, A.T. | | Deposit date: | 2010-12-22 | | Release date: | 2011-03-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystallographic, kinetic, and spectroscopic study of the first ligninolytic peroxidase presenting a catalytic tyrosine.
J.Biol.Chem., 286, 2011
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3I8D
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5AGY
 | | CRYSTAL STRUCTURE OF A TAU CLASS GST MUTANT FROM GLYCINE | | Descriptor: | 4-NITROPHENYL METHANETHIOL, GLUTATHIONE S-TRANSFERASE, PHOSPHATE ION, ... | | Authors: | Axarli, I, Muleta, A.W, Vlachakis, D, Kossida, S, Kotzia, G, Dhavala, P, Papageorgiou, A.C, Labrou, N.E. | | Deposit date: | 2015-02-04 | | Release date: | 2015-12-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Directed Evolution of Tau Class Glutathione Transferases Reveals a Site that Regulates Catalytic Efficiency and Masks Cooperativity.
Biochem.J., 473, 2016
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2LP6
 | | Refined Solution NMR Structure of the 50S ribosomal protein L35Ae from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target (NESG) PfR48 | | Descriptor: | 50S ribosomal protein L35Ae | | Authors: | Snyder, D.A, Aramini, J.M, Yu, B, Huang, Y.J, Xiao, R, Cort, J.R, Shastry, R, Ma, L, Liu, J, Rost, B, Acton, T.B, Kennedy, M.A, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2012-02-02 | | Release date: | 2012-02-15 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of the ribosomal protein RP-L35Ae from Pyrococcus furiosus.
Proteins, 80, 2012
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7PJD
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2MK6
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4OG4
 | | Human menin with bound inhibitor MIV-3S | | Descriptor: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | Deposit date: | 2014-01-15 | | Release date: | 2014-03-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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6R23
 | | The structure of a Ty3 retrotransposon capsid C-terminal domain dimer | | Descriptor: | Transposon Ty3-I Gag-Pol polyprotein | | Authors: | Dodonova, S.O, Prinz, S, Bilanchone, V, Sandmeyer, S, Briggs, J.A.G. | | Deposit date: | 2019-03-15 | | Release date: | 2019-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6R22
 | | The structure of a Ty3 retrotransposon capsid N-terminal domain dimer | | Descriptor: | Transposon Ty3-I Gag-Pol polyprotein | | Authors: | Dodonova, S.O, Prinz, S, Bilanchone, V, Sandmeyer, S, Briggs, J.A.G. | | Deposit date: | 2019-03-15 | | Release date: | 2019-05-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses.
Proc.Natl.Acad.Sci.USA, 116, 2019
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