5ZK3

Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB

Summary for 5ZK3

• Entry DOI: 10.2210/pdb5zk3/pdb
• Related: 5XBA 5XBB
• Descriptor: Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate (3 entities in total)
• Functional Keywords: gpcr crystallography, rationally thermostabilized mutant, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 47630.62

Authors

Suno, R.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Iwata, S.,Kobayashi, T. (deposition date: 2018-03-23, release date: 2018-11-21, Last modification date: 2022-03-23)

• Primary citation: Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.; Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor; Nat. Chem. Biol., 14:1150-1158, 2018; PubMed: 30420692; DOI: 10.1038/s41589-018-0152-y

Experimental method

X-RAY DIFFRACTION (2.6 Å)