5ZK3
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2 | polymer | 421 | 47293.2 | 1 | UniProt (P08172) Pfam (PF00001) Pfam (PF07361) UniProt (by SIFTS) (P0ABE7) In PDB | Homo sapiens (Human) | |
2 | A | (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate | non-polymer | 337.4 | 1 | Chemie (QNB) | |||
3 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 10 - 217 (UniProt: P08172)
A: 1001 - 1106 (PDB: 5ZK3)
A: 377 - 466 (UniProt: P08172)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Pro 0 | - | expression tag |
Met 1 | - | expression tag |
Asp 2 | - | expression tag |
Asp 3 | - | expression tag |
Ser 4 | - | expression tag |
Thr 5 | - | expression tag |
Asp 6 | - | expression tag |
Ser 7 | - | expression tag |
Ser 8 | - | expression tag |
Asp 9 | - | expression tag |
Arg 110 | Ser 110 | engineered mutation |
A: 377 - 466 (UniProt: P08172)
PDB | External Database | Details |
---|---|---|
Leu 467 | - | expression tag |
Glu 468 | - | expression tag |
Val 469 | - | expression tag |
Leu 470 | - | expression tag |
Phe 471 | - | expression tag |
Gln 472 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 47293.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 337.4 | |
All* | Total formula weight | 47630.6 |