6WQE

Solution Structure of the IWP-051-bound H-NOX from Shewanella woodyi in the Fe(II)CO ligation state

Summary for 6WQE

• Entry DOI: 10.2210/pdb6wqe/pdb
• Related: 6OCV
• NMR Information: BMRB: 27284
• Descriptor: Heme NO binding domain protein, 5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-ol, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• Functional Keywords: hemoprotein, nitric oxide, signaling, signaling protein, sgc stimulator complex
• Biological source: Shewanella woodyi
• Total number of polymer chains: 1
• Total formula weight: 22767.33

Authors

Chen, C.Y.,Lee, W.,Montfort, W.R. (deposition date: 2020-04-28, release date: 2020-07-22, Last modification date: 2021-03-03)

• Primary citation: Chen, C.Y.,Lee, W.,Renhowe, P.A.,Jung, J.,Montfort, W.R.; Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051.; Protein Sci., 30:448-463, 2021; PubMed: 33236796; DOI: 10.1002/pro.4005

Experimental method

SOLUTION NMR