1IHI

Crystal Structure of Human Type III 3-alpha-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein (AKR1C2) Complexed with NADP+ and Ursodeoxycholate

Summary for 1IHI

Entry DOI	10.2210/pdb1ihi/pdb
Descriptor	3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISO-URSODEOXYCHOLIC ACID (3 entities in total)
Functional Keywords	alpha-beta barrel, ternary complex, protein-nadp-bile acid complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (Potential): P52895
Total number of polymer chains	2
Total formula weight	75844.49
Authors	Jin, Y.,Stayrook, S.E.,Albert, R.H.,Palackal, N.T.,Penning, T.M.,Lewis, M. (deposition date: 2001-04-19, release date: 2001-10-03, Last modification date: 2023-08-16)
Primary citation	Jin, Y.,Stayrook, S.E.,Albert, R.H.,Palackal, N.T.,Penning, T.M.,Lewis, M. Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Biochemistry, 40:10161-10168, 2001 Cited by PubMed: 11513593 DOI: 10.1021/bi010919a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation