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8ATG	Pentameric ligand-gated ion channel GLIC with bound lipids Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Proton-gated ion channel Authors: Bergh, C, Rovsnik, U, Howard, R.J, Lindahl, E. Deposit date: 2022-08-23 Release date: 2023-09-06 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM. Elife, 12, 2024
1JVM	KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM Descriptor: RUBIDIUM ION, TETRABUTYLAMMONIUM ION, Voltage-gated potassium channel Authors: Morais-Cabral, J.H, Zhou, Y, MacKinnon, R. Deposit date: 2001-08-30 Release date: 2001-12-05 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature, 414, 2001
2AEM	Crystal Structures of the MthK RCK Domain Descriptor: Calcium-gated potassium channel mthK Authors: Dong, J, Shi, N, Berke, I, Chen, L, Jiang, Y. Deposit date: 2005-07-22 Release date: 2005-10-25 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structures of the MthK RCK Domain and the Effect of Ca2+ on Gating Ring Stability J.Biol.Chem., 280, 2005
2AEJ	Crystal Structures of the MthK RCK Domain in no Ca2+ bound form Descriptor: Calcium-gated potassium channel mthK Authors: Dong, J, Shi, N, Berke, I, Chen, L, Jiang, Y. Deposit date: 2005-07-22 Release date: 2005-10-25 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structures of the MthK RCK Domain and the Effect of Ca2+ on Gating Ring Stability J.Biol.Chem., 280, 2005
5HCJ	Cationic Ligand-Gated Ion Channel Descriptor: CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel, ... Authors: Shahsavar, A, Sauguet, L, Delarue, M. Deposit date: 2016-01-04 Release date: 2016-04-13 Last modified: 2016-04-20 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel. Structure, 24, 2016
3K6N	Crystal structure of the S225E mutant Kir3.1 cytoplasmic pore domain Descriptor: G protein-activated inward rectifier potassium channel 1, SODIUM ION Authors: Xu, Y, Shin, H.G, Szep, S, Lu, Z. Deposit date: 2009-10-09 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Physical determinants of strong voltage sensitivity of K(+) channel block. Nat.Struct.Mol.Biol., 16, 2009
5HCM	The GLIC pentameric Ligand-Gated Ion Channel 2-21' cross-linked mutant complexed to bromoform Descriptor: DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel, TRIBROMOMETHANE Authors: Shahsavar, A, Sauguet, L, Delarue, M. Deposit date: 2016-01-04 Release date: 2016-04-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel. Structure, 24, 2016
3LDE	High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in 100 mM Na+. Descriptor: Calcium-gated potassium channel mthK, SODIUM ION Authors: Ye, S. Deposit date: 2010-01-12 Release date: 2010-08-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.208 Å) Cite: Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore. Nat.Struct.Mol.Biol., 17, 2010
1QX5	Crystal structure of apoCalmodulin Descriptor: Calmodulin Authors: Schumacher, M.A, Crum, M, Miller, M.C. Deposit date: 2003-09-04 Release date: 2004-08-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. STRUCTURE, 12, 2004
8DGH	NMR Structure of calmodulin bound to C-terminal site in the beta-subunit of cyclic nucleotide-gated channel Descriptor: Calmodulin-1, Cyclic nucleotide-gated cation channel beta-1 Authors: Bej, A, Ames, J.B. Deposit date: 2022-06-23 Release date: 2022-12-14 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Structures of Calmodulin Bound to Two Separate Regulatory Sites in the Retinal Cyclic Nucleotide-Gated Channel. Biochemistry, 61, 2022
8DGK	NMR structure of calmodulin bound to N-terminal site in the beta-subunit of cyclic nucleotide-gated channel Descriptor: Calmodulin-1, Cyclic nucleotide-gated cation channel beta-1 Authors: Bej, A, Ames, J.B. Deposit date: 2022-06-23 Release date: 2022-12-14 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Structures of Calmodulin Bound to Two Separate Regulatory Sites in the Retinal Cyclic Nucleotide-Gated Channel. Biochemistry, 61, 2022
7XNI	human KCNQ1-CaM in apo state Descriptor: Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 1 Authors: Ma, D, Guo, J. Deposit date: 2022-04-28 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
4LMK	GLIC Liganded-closed-channel Conformation, Mutant Y27'A Descriptor: CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel, ... Authors: Grosman, C, Gonzalez-Gutierrez, G. Deposit date: 2013-07-10 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proc.Natl.Acad.Sci.USA, 110, 2013
4LMJ	GLIC Liganded-closed-channel Conformation, Mutant T25'A Descriptor: CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Proton-gated ion channel, ... Authors: Grosman, C, Gonzalez-Gutierrez, G. Deposit date: 2013-07-10 Release date: 2013-10-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.44 Å) Cite: Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proc.Natl.Acad.Sci.USA, 110, 2013
3U6N	Open Structure of the BK channel Gating Ring Descriptor: CALCIUM ION, High-Conductance Ca2+-Activated K+ Channel protein Authors: Yuan, P, MacKinnon, R. Deposit date: 2011-10-12 Release date: 2011-12-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.61 Å) Cite: Open structure of the Ca(2+) gating ring in the high-conductance Ca(2+)-activated K(+) channel. Nature, 481, 2011
1QRQ	STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (KV BETA2 PROTEIN) Authors: Gulbis, J.M, Mann, S, MacKinnon, R. Deposit date: 1999-06-15 Release date: 1999-10-27 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of a voltage-dependent K+ channel beta subunit. Cell(Cambridge,Mass.), 97, 1999
1WXN	Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels Descriptor: Toxin APETx2 Authors: Chagot, B, Escoubas, P, Diochot, S, Bernard, C, Lazdunski, M, Darbon, H. Deposit date: 2005-01-27 Release date: 2005-08-16 Last modified: 2024-10-30 Method: SOLUTION NMR Cite: Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels Protein Sci., 14, 2005
8TEO	Shaker in low K+ (4mM K+) Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker Authors: Tan, X, Swartz, K.J. Deposit date: 2023-07-06 Release date: 2023-12-20 Method: ELECTRON MICROSCOPY (2.39 Å) Cite: Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse. Sci Adv, 9, 2023
3S3X	Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, neuronal, ... Authors: Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A. Deposit date: 2011-05-18 Release date: 2012-05-23 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1. Nat Commun, 3, 2012
6CQ8	K2P2.1(TREK-1):ML335 complex Descriptor: CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... Authors: Lolicato, M, Minor, D.L. Deposit date: 2018-03-14 Release date: 2018-03-28 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3 Å) Cite: K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature, 547, 2017
6CQ9	K2P2.1(TREK-1):ML402 complex Descriptor: CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... Authors: Lolicato, M, Minor, D.L. Deposit date: 2018-03-14 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature, 547, 2017
6CQ6	K2P2.1(TREK-1) apo structure Descriptor: CADMIUM ION, DECANE, POTASSIUM ION, ... Authors: Lolicato, M, Minor, D.L. Deposit date: 2018-03-14 Release date: 2018-03-28 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature, 547, 2017
4HFB	The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo) Descriptor: ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... Authors: Sauguet, L, Howard, R.J, Malherbe, L, Lee, U.S, Corringer, P.J, Harris, R.A, Delarue, M. Deposit date: 2012-10-05 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun, 4, 2013
4HFH	The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform Descriptor: ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... Authors: Sauguet, L, Howard, R.J, Malherbe, L, Lee, U.S, Corringer, P.J, Harris, R.A, Delarue, M. Deposit date: 2012-10-05 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun, 4, 2013
4QE7	Open MthK pore structure soaked in 10 mM Ba2+/100 mM Na+ Descriptor: BARIUM ION, Calcium-gated potassium channel MthK Authors: Guo, R, Zeng, W, Cui, H, Chen, L, Ye, S. Deposit date: 2014-05-15 Release date: 2014-07-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ionic interactions of Ba2+ blockades in the MthK K+ channel J.Gen.Physiol., 144, 2014

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