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1ON3	Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CADMIUM ION, METHYLMALONIC ACID, ... Authors: Hall, P.R, Wang, Y.-F, Rivera-Hainaj, R.E, Zheng, X, Pustai-Carey, M, Carey, P.R, Yee, V.C. Deposit date: 2003-02-26 Release date: 2003-05-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core Embo J., 22, 2003
1PIX	Crystal structure of the carboxyltransferase subunit of the bacterial ion pump glutaconyl-coenzyme A decarboxylase Descriptor: FORMIC ACID, Glutaconyl-CoA decarboxylase A subunit, SULFATE ION Authors: Wendt, K.S, Schall, I, Huber, R, Buckel, W, Jacob, U. Deposit date: 2003-05-30 Release date: 2003-08-05 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase Embo J., 22, 2003
5CTB	Humanized yeast ACC carboxyltransferase domain bound to 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one Descriptor: 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one, Acetyl-CoA carboxylase, SULFATE ION Authors: Vajdos, F.F. Deposit date: 2015-07-23 Release date: 2015-10-14 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25, 2015
5CTE	Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate Descriptor: 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, Acetyl-CoA carboxylase, SULFATE ION Authors: Vajdos, F.F. Deposit date: 2015-07-23 Release date: 2015-10-14 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25, 2015
5CTC	Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate Descriptor: Acetyl-CoA carboxylase, SULFATE ION, tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate Authors: Vajdos, F.F. Deposit date: 2015-07-23 Release date: 2015-10-14 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. Bioorg.Med.Chem.Lett., 25, 2015
1OD4	Acetyl-CoA Carboxylase Carboxyltransferase Domain Descriptor: ACETYL-COENZYME A CARBOXYLASE, ADENINE Authors: Zhang, H, Yang, Z, Shen, Y, Tong, L. Deposit date: 2003-02-12 Release date: 2003-04-03 Last modified: 2018-06-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science, 299, 2003
1UYR	Acetyl-CoA Carboxylase Carboxyltransferase Domain in complex with inhibitor Diclofop Descriptor: 2-[4-(2,4-DICHLOROPHENOXY)PHENOXY]PROPANOIC ACID, ACETYL-COA CARBOXYLASE Authors: Zhang, H, Tweel, B, Tong, L. Deposit date: 2004-03-02 Release date: 2004-03-29 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop Proc.Natl.Acad.Sci.USA, 101, 2004
1UYS	Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor haloxyfop Descriptor: (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, ACETYL-COA CARBOXYLASE Authors: Zhang, H, Tweel, B, Tong, L. Deposit date: 2004-03-02 Release date: 2004-03-29 Last modified: 2012-06-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop Proc.Natl.Acad.Sci.USA, 101, 2004
1ON9	Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core (with hydrolyzed methylmalonyl-coenzyme a bound) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CADMIUM ION, METHYLMALONYL-COENZYME A, ... Authors: Hall, P.R, Wang, Y.-F, Rivera-Hainaj, R.E, Zheng, X, Pustai-Carey, M, Carey, P.R, Yee, V.C. Deposit date: 2003-02-27 Release date: 2003-05-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core Embo J., 22, 2003
1OD2	Acetyl-CoA Carboxylase Carboxyltransferase Domain Descriptor: ACETYL COENZYME *A, ACETYL-COENZYME A CARBOXYLASE, ADENINE Authors: Zhang, H, Yang, Z, Shen, Y, Tong, L. Deposit date: 2003-02-12 Release date: 2003-04-03 Last modified: 2018-06-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science, 299, 2003
1UYV	Acetyl-CoA carboxylase carboxyltransferase domain L1705I/V1967I mutant Descriptor: ACETYL-COA CARBOXYLASE Authors: Zhang, H, Tweel, B, Tong, L. Deposit date: 2004-03-02 Release date: 2004-03-29 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop Proc.Natl.Acad.Sci.USA, 101, 2004
1UYT	Acetyl-CoA carboxylase carboxyltransferase domain Descriptor: ACETYL-COA CARBOXYLASE Authors: Zhang, H, Tweel, B, Tong, L. Deposit date: 2004-03-02 Release date: 2004-03-29 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop. Proc.Natl.Acad.Sci.USA, 101, 2004
1VRG	Crystal structure of propionyl-CoA carboxylase, beta subunit (TM0716) from THERMOTOGA MARITIMA at 2.30 A resolution Descriptor: BICARBONATE ION, MAGNESIUM ION, propionyl-CoA carboxylase, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2005-02-22 Release date: 2005-03-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of propionyl-CoA carboxylase, beta subunit (TM0716) from THERMOTOGA MARITIMA at 2.30 A resolution To be published
1X0U	Crystal Structure of the carboxyl transferase subunit of putative PCC of Sulfolobus tokodaii Descriptor: hypothetical methylmalonyl-CoA decarboxylase alpha subunit Authors: Kakuta, Y, Sueda, S, Kondo, H. Deposit date: 2005-03-29 Release date: 2006-07-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the carboxyl transferase subunit of putative PCC of Sulfolobus tokodaii To be Published
1XNY	Biotin and propionyl-CoA bound to Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB) Descriptor: BIOTIN, propionyl Coenzyme A, propionyl-CoA carboxylase complex B subunit Authors: Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. Deposit date: 2004-10-05 Release date: 2004-11-09 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
1XO6	Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #3 Descriptor: propionyl-CoA carboxylase complex B subunit Authors: Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. Deposit date: 2004-10-05 Release date: 2004-11-09 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
1XNV	Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1 Descriptor: propionyl-CoA carboxylase complex B subunit Authors: Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. Deposit date: 2004-10-05 Release date: 2004-11-09 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
1XNW	Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #2, mutant D422I Descriptor: propionyl-CoA carboxylase complex B subunit Authors: Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. Deposit date: 2004-10-05 Release date: 2004-11-09 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
2A7S	Crystal Structure of the Acyl-CoA Carboxylase, AccD5, from Mycobacterium tuberculosis Descriptor: Probable propionyl-CoA carboxylase beta chain 5 Authors: Lin, T, Melgar, M, Purdon, J, Tseng, T, Tsai, S.C. Deposit date: 2005-07-06 Release date: 2006-02-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.Usa, 103, 2006
3FF6	Human ACC2 CT domain with CP-640186 Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, Acetyl-CoA carboxylase 2 Authors: Williams, S.P, Madauss, K.P, Burkhart, W.A. Deposit date: 2008-12-02 Release date: 2009-05-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.19 Å) Cite: The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. Acta Crystallogr.,Sect.D, 65, 2009
3TV5	Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 1 Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, Acetyl-CoA carboxylase Authors: Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F. Deposit date: 2011-09-19 Release date: 2011-10-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion. J.Biol.Chem., 286, 2011
3GF7	Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein Descriptor: Glutaconyl-CoA decarboxylase subunit A, SULFATE ION Authors: Kress, D, Brugel, D, Buckel, W, Essen, L.-O. Deposit date: 2009-02-26 Release date: 2009-07-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases J.Biol.Chem., 284, 2009
3U9R	Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC), beta subunit Descriptor: Methylcrotonyl-CoA carboxylase, beta-subunit, PENTAETHYLENE GLYCOL, ... Authors: Huang, C.S, Tong, L. Deposit date: 2011-10-19 Release date: 2011-12-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature, 481, 2012
3GF3	Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum co-crystallized with glutaconyl-coA Descriptor: CHLORIDE ION, CROTONYL COENZYME A, Glutaconyl-CoA decarboxylase subunit A Authors: Kress, D, Brugel, D, Buckel, W, Essen, L.-O. Deposit date: 2009-02-26 Release date: 2009-07-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases J.Biol.Chem., 284, 2009
3TVW	Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 4 Descriptor: Acetyl-CoA carboxylase, [4-(2H-chromen-3-ylmethyl)piperazin-1-yl]-[3-(1H-pyrazol-5-yl)phenyl]methanone Authors: Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F. Deposit date: 2011-09-20 Release date: 2011-10-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion. J.Biol.Chem., 286, 2011

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