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7BUX
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BU of 7bux by Molmil
Eucommia ulmoides FPS1
Descriptor: FPS2
Authors:Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y.
Deposit date:2020-04-08
Release date:2021-02-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
7BUW
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BU of 7buw by Molmil
Eucommia ulmoides TPT3 mutant -C94Y/A95F
Descriptor: FPS3
Authors:Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y.
Deposit date:2020-04-08
Release date:2021-02-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
7BUV
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BU of 7buv by Molmil
Eucommia ulmoides TPT3, crystal form 2
Descriptor: FPS3
Authors:Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y.
Deposit date:2020-04-08
Release date:2021-02-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
7BUU
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BU of 7buu by Molmil
Eucommia ulmoides TPT3, crystal form 1
Descriptor: FPS3
Authors:Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y.
Deposit date:2020-04-08
Release date:2021-02-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
4DWB
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BU of 4dwb by Molmil
Crystal structure of Trypanosoma cruzi farnesyl diphosphate synthase in complex with [2-(n-pentylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+
Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, Farnesyl pyrophosphate synthase, ...
Authors:Aripirala, S, Amzel, L.M, Gabelli, S.B.
Deposit date:2012-02-24
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
J.Med.Chem., 55, 2012
4DHD
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BU of 4dhd by Molmil
Crystal structure of isoprenoid synthase A3MSH1 (TARGET EFI-501992) from Pyrobaculum calidifontis
Descriptor: ACETATE ION, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2012-01-27
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
2RAH
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BU of 2rah by Molmil
Human FDPS synthase in complex with novel inhibitor
Descriptor: Farnesyl pyrophosphate synthetase, MAGNESIUM ION, SULFATE ION, ...
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2007-09-15
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human FDPS synthase in complex with novel inhibitor
To be Published
2VF6
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BU of 2vf6 by Molmil
Human FDPS synthase in complex with minodronate
Descriptor: (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), FARNESYL PYROPHOSPHATE SYNTHETASE, MAGNESIUM ION
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2007-10-31
Release date:2007-11-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Fdps Synthase in Complex with Novel Inhibitor
To be Published
2QIS
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BU of 2qis by Molmil
Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate
Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthetase, MAGNESIUM ION
Authors:Kavanagh, K.L, Dunford, J.E, Hozjan, V, Evdokimov, A, Gileadi, O, von Delft, F, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-07-05
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate.
To be Published
2Q80
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BU of 2q80 by Molmil
Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP
Descriptor: GERANYLGERANYL DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION
Authors:Kavanagh, K.L, Dunford, J.E, Bunkoczi, G, Smee, C, von Delft, F, Arrowsmith, C, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-06-08
Release date:2007-06-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding
J.Biol.Chem., 281, 2006
6N7Y
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BU of 6n7y by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-102
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, PHOSPHATE ION, ...
Authors:Park, J, Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
6N83
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BU of 6n83 by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037
Descriptor: CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ...
Authors:Park, J, Schilling, M.A, Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
6N7Z
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BU of 6n7z by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037
Descriptor: CHLORIDE ION, Farnesyl pyrophosphate synthase, GLYCEROL, ...
Authors:Park, J, Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
5HN7
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BU of 5hn7 by Molmil
Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1158
Descriptor: 5-(morpholin-4-ylsulfonyl)-2-{[3-(octyloxy)benzyl]oxy}benzoic acid, Farnesyl pyrophosphate synthase, putative
Authors:Liu, Y.-L, Zhang, Y, Oldfield, E.
Deposit date:2016-01-18
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
Biochemistry, 55, 2016
5HNA
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BU of 5hna by Molmil
Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1251
Descriptor: 4-chloro-2-{[3-(decyloxy)-5-hydroxybenzyl]oxy}-5-sulfamoylbenzoic acid, Farnesyl pyrophosphate synthase, putative
Authors:Liu, Y.-L, Zhang, Y, Oldfield, E.
Deposit date:2016-01-18
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
Biochemistry, 55, 2016
5HN8
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BU of 5hn8 by Molmil
Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1182
Descriptor: 2-{[3-hydroxy-5-(octyloxy)benzyl]sulfanyl}benzoic acid, Farnesyl pyrophosphate synthase, putative, ...
Authors:Liu, Y.-L, Zhang, Y, Oldfield, E.
Deposit date:2016-01-18
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
Biochemistry, 55, 2016
5HN9
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BU of 5hn9 by Molmil
Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1186
Descriptor: 2-{[3-(decyloxy)benzyl]oxy}-5-nitrobenzoic acid, Farnesyl pyrophosphate synthase, putative
Authors:Liu, Y.-L, Zhang, Y, OIdfield, E.
Deposit date:2016-01-18
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
Biochemistry, 55, 2016
6OAH
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BU of 6oah by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-78
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, PHOSPHATE ION, ...
Authors:Park, J, Berghuis, A.M.
Deposit date:2019-03-16
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
3ZMB
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BU of 3zmb by Molmil
Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound fragment SPB02696.
Descriptor: 3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Schmidberger, J.W, Schnell, R, Schneider, G.
Deposit date:2013-02-07
Release date:2014-02-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa
Acta Crystallogr.,Sect.D, 71, 2015
3ZOU
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BU of 3zou by Molmil
Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound fragment SPB02696, and substrate geranyl pyrophosphate.
Descriptor: 3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid, DIMETHYL SULFOXIDE, FARNESYL PYROPHOSPHATE SYNTHASE, ...
Authors:Schmidberger, J.W, Schnell, R, Schneider, G.
Deposit date:2013-02-25
Release date:2014-03-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa
Acta Crystallogr.,Sect.D, 71, 2015
3ZL6
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BU of 3zl6 by Molmil
Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PAO1, with bound fragment KM10833.
Descriptor: 2-(1,2-benzoxazol-3-yl)ethanoic acid, DIMETHYL SULFOXIDE, GERANYLTRANSTRANSFERASE, ...
Authors:Schmidberger, J.W, Schnell, R, Schneider, G.
Deposit date:2013-01-28
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa.
Acta Crystallogr.,Sect.D, 71, 2015
3ZMC
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BU of 3zmc by Molmil
Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound substrate molecule Geranyl pyrophosphate.
Descriptor: DIMETHYL SULFOXIDE, GERANYL DIPHOSPHATE, GERANYLTRANSTRANSFERASE, ...
Authors:Schmidberger, J.W, Schnell, R, Schneider, G.
Deposit date:2013-02-07
Release date:2014-02-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa
Acta Crystallogr.,Sect.D, 71, 2015
6OAG
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BU of 6oag by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-82
Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION, [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid
Authors:Park, J, Berghuis, A.M.
Deposit date:2019-03-16
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
7S0L
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BU of 7s0l by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, S723F
Descriptor: Terpene synthase
Authors:Ronnebaum, T.A, Christianson, D.W.
Deposit date:2021-08-30
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021
7S0H
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BU of 7s0h by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, S723Y
Descriptor: Terpene synthase
Authors:Ronnebaum, T.A, Christianson, D.W.
Deposit date:2021-08-30
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021

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