8P4U
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![BU of 8p4u by Molmil](/molmil-images/mine/8p4u) | Alpha-1-antitrypsin - Sydney variant (G192C) | Descriptor: | Alpha-1-antitrypsin | Authors: | Kamuda, K, Lomas, D.A, Irving, J.A. | Deposit date: | 2023-05-23 | Release date: | 2024-04-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. Febs J., 291, 2024
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8PI2
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5C98
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![BU of 5c98 by Molmil](/molmil-images/mine/5c98) | 1.45A resolution structure of SRPN18 from Anopheles gambiae | Descriptor: | AGAP007691-PB | Authors: | Lovell, S, Battaile, K.P, Gulley, M, Zhang, X, Meekins, D.A, Gao, F.P, Michel, K. | Deposit date: | 2015-06-26 | Release date: | 2016-09-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | 1.45 angstrom resolution structure of SRPN18 from the malaria vector Anopheles gambiae. Acta Crystallogr F Struct Biol Commun, 72, 2016
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3T1P
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8API
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![BU of 8api by Molmil](/molmil-images/mine/8api) | THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-1 ANTITRYPSIN (CHAIN A), ... | Authors: | Loebermann, H, Tokuoka, R, Deisenhofer, J, Huber, R. | Deposit date: | 1988-09-08 | Release date: | 1990-10-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism. Protein Eng., 2, 1989
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3STO
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![BU of 3sto by Molmil](/molmil-images/mine/3sto) | Serpin from the trematode Schistosoma Haematobium | Descriptor: | Serine protease inhibitor | Authors: | Granzin, J, Weiergraeber, O.H, Lee, X, Blanton, R.E. | Deposit date: | 2011-07-11 | Release date: | 2012-05-30 | Last modified: | 2013-01-23 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain. Acta Crystallogr.,Sect.D, 68, 2012
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5EI0
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![BU of 5ei0 by Molmil](/molmil-images/mine/5ei0) | Structure of RCL-cleaved vaspin (serpinA12) | Descriptor: | Serpin A12 | Authors: | Pippel, J, Kuettner, B.E, Ulbricht, D, Daberger, J, Schultz, S, Heiker, J.T, Strater, N. | Deposit date: | 2015-10-29 | Release date: | 2015-11-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of cleaved vaspin (serpinA12). Biol.Chem., 397, 2016
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7ZBF
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![BU of 7zbf by Molmil](/molmil-images/mine/7zbf) | Crystal structure of native Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | Iripin-4 serpin, NICKEL (II) ION | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-23 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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7ZAS
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![BU of 7zas by Molmil](/molmil-images/mine/7zas) | Crystal structure of cleaved Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | CHLORIDE ION, Iripin-4 serpin | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-22 | Release date: | 2023-03-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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3R4L
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![BU of 3r4l by Molmil](/molmil-images/mine/3r4l) | Human very long half life Plasminogen Activator Inhibitor type-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasminogen activator inhibitor 1, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yang, J, Zheng, H, Han, Q, Skrzypczak-Jankun, E, Jankun, J. | Deposit date: | 2011-03-17 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure. Int.J.Mol.Med., 29, 2012
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5DU3
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![BU of 5du3 by Molmil](/molmil-images/mine/5du3) | Active form of human C1-inhibitor | Descriptor: | Plasma protease C1 inhibitor | Authors: | Pannu, N.S, Dijk, M, Holkers, J, Voskamp, P, Giannetti, B.M, Waterreus, W.J, van Veen, H.A. | Deposit date: | 2015-09-18 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure, 24, 2016
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5HGC
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![BU of 5hgc by Molmil](/molmil-images/mine/5hgc) | A Serpin structure | Descriptor: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, SULFATE ION, ... | Authors: | Das, S, Vashchenko, G.V, Van Petegem, F. | Deposit date: | 2016-01-08 | Release date: | 2016-04-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | A Serpin structure J.Biol.Chem., 2016
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1F0C
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![BU of 1f0c by Molmil](/molmil-images/mine/1f0c) | STRUCTURE OF THE VIRAL SERPIN CRMA | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ICE INHIBITOR | Authors: | Renatus, M, Zhou, Q, Stennicke, H.R, Snipas, S.J, Turk, D, Bankston, L.A, Liddington, R.C, Salvesen, G.S. | Deposit date: | 2000-05-15 | Release date: | 2000-09-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Crystal structure of the apoptotic suppressor CrmA in its cleaved form. Structure Fold.Des., 8, 2000
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7QRN
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![BU of 7qrn by Molmil](/molmil-images/mine/7qrn) | Crystal structure of Ovalbumin-related protein X (OVAX) complexed with fondaparinux | Descriptor: | 1,2-ETHANEDIOL, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, Ovalbumin-related protein X, ... | Authors: | Coste, F, Bruneau, G, Rehault-Godbert, S. | Deposit date: | 2022-01-11 | Release date: | 2022-11-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Antimicrobial Proteins and Peptides in Avian Eggshell: Structural Diversity and Potential Roles in Biomineralization. Front Immunol, 13, 2022
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7QR2
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7QTZ
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![BU of 7qtz by Molmil](/molmil-images/mine/7qtz) | Crystal structure of Iripin-1 serpin from tick Ixodes ricinus | Descriptor: | MAGNESIUM ION, Putative salivary serpin | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-01-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules. Front Immunol, 14, 2023
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7RBW
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![BU of 7rbw by Molmil](/molmil-images/mine/7rbw) | Structure of Biliverdin-binding Serpin of Boana punctata (polka-dot tree frog) | Descriptor: | BILIVERDINE IX ALPHA, Biliverdin bindin serpin | Authors: | Fedorov, E, Manoilov, K.Y, Verkhusha, V, Almo, S.C, Ghosh, A. | Deposit date: | 2021-07-06 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural and Functional Characterization of a Biliverdin-Binding Near-Infrared Fluorescent Protein From the Serpin Superfamily. J.Mol.Biol., 434, 2021
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1HP7
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![BU of 1hp7 by Molmil](/molmil-images/mine/1hp7) | A 2.1 ANGSTROM STRUCTURE OF AN UNCLEAVED ALPHA-1-ANTITRYPSIN SHOWS VARIABILITY OF THE REACTIVE CENTER AND OTHER LOOPS | Descriptor: | ALPHA-1-ANTITRYPSIN, BETA-MERCAPTOETHANOL, ZINC ION | Authors: | Kim, S.-J, Woo, J.-R, Seo, E.J, Yu, M.-H, Ryu, S.-E. | Deposit date: | 2000-12-12 | Release date: | 2001-03-14 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops. J.Mol.Biol., 306, 2001
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1HLE
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![BU of 1hle by Molmil](/molmil-images/mine/1hle) | CRYSTAL STRUCTURE OF CLEAVED EQUINE LEUCOCYTE ELASTASE INHIBITOR DETERMINED AT 1.95 ANGSTROMS RESOLUTION | Descriptor: | CALCIUM ION, HORSE LEUKOCYTE ELASTASE INHIBITOR | Authors: | Baumann, U, Bode, W, Huber, R, Travis, J, Potempa, J. | Deposit date: | 1992-04-13 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution. J.Mol.Biol., 226, 1992
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2ARR
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![BU of 2arr by Molmil](/molmil-images/mine/2arr) | Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagmggvmtgr-oh | Descriptor: | 14-mer from Plasminogen activator inhibitor-2, Plasminogen activator inhibitor-2 | Authors: | Di Giusto, D.A, Sutherland, A.P, Jankova, L, Harrop, S.J, Curmi, P.M, King, G.C. | Deposit date: | 2005-08-21 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities J.Mol.Biol., 353, 2005
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4G8O
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![BU of 4g8o by Molmil](/molmil-images/mine/4g8o) | Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | Descriptor: | (2S)-3-({[3-(trifluoromethyl)phenoxy]carbonyl}amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate), 1,2-ETHANEDIOL, Plasminogen activator inhibitor 1, ... | Authors: | Stuckey, J.A, Lawrence, D.A, Li, S.-H. | Deposit date: | 2012-07-23 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc.Natl.Acad.Sci.USA, 110, 2013
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4GA7
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![BU of 4ga7 by Molmil](/molmil-images/mine/4ga7) | Crystal structure of human serpinB1 mutant | Descriptor: | Leukocyte elastase inhibitor | Authors: | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2012-07-25 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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2B4X
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2ANT
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![BU of 2ant by Molmil](/molmil-images/mine/2ant) | THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE | Descriptor: | 2-acetamido-2-deoxy-beta-D-allopyranose, ANTITHROMBIN | Authors: | Skinner, R, Abrahams, J.-P, Whisstock, J.C, Lesk, A.M, Carrell, R.W, Wardell, M.R. | Deposit date: | 1997-01-28 | Release date: | 1997-06-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J.Mol.Biol., 266, 1997
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2ARQ
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![BU of 2arq by Molmil](/molmil-images/mine/2arq) | Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh | Descriptor: | 14-mer from Plasminogen activator inhibitor-2, Plasminogen activator inhibitor-2 | Authors: | Di Giusto, D.A, Sutherland, A.P, Jankova, L, Harrop, S.J, Curmi, P.M, King, G.C. | Deposit date: | 2005-08-21 | Release date: | 2006-07-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Plasminogen activator inhibitor-2 is highly tolerant to P8 residue substitution--implications for serpin mechanistic model and prediction of nsSNP activities J.Mol.Biol., 353, 2005
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