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6WM1	Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl Descriptor: ACE-PTR-02K-ASN-PRA, CALCIUM ION, CHLORIDE ION, ... Authors: Martin, S.F, Clements, J.H. Deposit date: 2020-04-20 Release date: 2020-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
6VK2	NMR solution structure of Grb2-SH2 domain at pH 7 Descriptor: Growth factor receptor-bound protein 2 Authors: Sanches, K, Caruso, I.P, Melo, F.A, Almeida, F.C.L. Deposit date: 2020-01-18 Release date: 2020-07-29 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions. Sci Rep, 10, 2020
6WO2	Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl Descriptor: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ... Authors: Martin, S.F, Clements, J.H. Deposit date: 2020-04-24 Release date: 2020-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
6WAX	C-terminal SH2 domain of p120RasGAP Descriptor: 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION Authors: Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. Deposit date: 2020-03-26 Release date: 2020-06-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020
6ICH	Grb2 SH2 domain in domain swapped dimer form Descriptor: Growth factor receptor-bound protein 2 Authors: Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. Deposit date: 2018-09-06 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
6ICG	Grb2 SH2 domain in phosphopeptide free form Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION Authors: Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. Deposit date: 2018-09-06 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
4QSY	SHP2 SH2 domain in complex with GAB1 peptide Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Gogl, G, Remenyi, A. Deposit date: 2014-07-06 Release date: 2015-07-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
6PXC	N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide Descriptor: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP Authors: Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. Deposit date: 2019-07-25 Release date: 2019-12-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide Descriptor: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase Authors: Lubman, O.Y, Waksman, G. Deposit date: 2001-11-07 Release date: 2002-04-17 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1KA7	SAP/SH2D1A bound to peptide n-Y-c Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-pY Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2021-10-27 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
4ROJ	Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide Descriptor: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION Authors: Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2014-10-28 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
6R5G	C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1 Descriptor: ITSM, Tyrosine-protein phosphatase non-receptor type 11 Authors: Marasco, M. Deposit date: 2019-03-25 Release date: 2020-02-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
7MP3	Grb7-SH2 domain in complex with bicyclic peptide B8 Descriptor: Growth factor receptor-bound protein 7, bicyclic peptide B8 Authors: Colson, R, Wilce, M.C.J, Wilce, J.A. Deposit date: 2021-05-04 Release date: 2022-02-02 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability. Biomedicines, 10, 2022
4U1P	Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide Descriptor: Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-16 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide To Be Published
4U17	Swapped dimer of the human Fyn-SH2 domain Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-15 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Swapped dimer of the human Fyn-SH2 domain To Be Published
4TZI	Structure of unliganded Lyn SH2 domain Descriptor: Tyrosine-protein kinase Lyn Authors: Wybenga-Groot, L.E. Deposit date: 2014-07-10 Release date: 2015-01-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
6PXB	N-Terminal SH2 domain of the p120RasGAP Descriptor: Ras GTPase-activating protein 1 Authors: Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J. Deposit date: 2019-07-25 Release date: 2019-12-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.747 Å) Cite: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Plos One, 14, 2019
6ROY	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) Authors: Krausze, J, Sikorska, J, Carlomagno, T. Deposit date: 2019-05-13 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
6ROZ	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM) Authors: Krausze, J, Sikorska, J, Carlomagno, T. Deposit date: 2019-05-13 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
7NXE	Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide Descriptor: Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15 Authors: Ssebyatika, G, Krey, T. Deposit date: 2021-03-18 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation. Plos Pathog., 17, 2021
7MPH	GRB2 SH2 Domain with Compound 7 Descriptor: (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... Authors: Sun, L, Schonbrunn, E. Deposit date: 2021-05-04 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
6SM5	MbC/SHP1-C-SH2 complex Descriptor: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6 Authors: Mann, G, Hantschel, O. Deposit date: 2019-08-21 Release date: 2021-01-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: MbC/SHP1-C-SH2 complex To Be Published

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