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6WAX
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BU of 6wax by Molmil
C-terminal SH2 domain of p120RasGAP
Descriptor: 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION
Authors:Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J.
Deposit date:2020-03-26
Release date:2020-06-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
J.Biol.Chem., 295, 2020
3EAC
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BU of 3eac by Molmil
Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form.
Descriptor: Tyrosine-protein kinase CSK
Authors:Liu, D, Seidel, R.D, Cowburn, D.
Deposit date:2008-08-25
Release date:2009-11-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase.
Biophys Rep, 2, 2016
6E8M
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BU of 6e8m by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide
Descriptor: DnaJ-A1 pTyr381 peptide, LeSH (Llo2327)
Authors:Kaneko, T, Li, S.S.C.
Deposit date:2018-07-30
Release date:2018-11-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
6E8I
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BU of 6e8i by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to phosphotyrosine
Descriptor: LeSH (Llo2327), O-PHOSPHOTYROSINE
Authors:Kaneko, T, Li, S.S.C.
Deposit date:2018-07-29
Release date:2018-11-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
6E8H
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BU of 6e8h by Molmil
Legionella Longbeachae LeSH (Llo2327)
Descriptor: CHLORIDE ION, LeSH (Llo2327)
Authors:Kaneko, T, Li, S.S.C.
Deposit date:2018-07-29
Release date:2018-11-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
6E8K
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BU of 6e8k by Molmil
Legionella Longbeachae LeSH (Llo2327) bound to the human interleukin-2 receptor beta pTyr387 peptide
Descriptor: LeSH (Llo2327), interleukin-2 receptor beta pTyr387 peptide
Authors:Kaneko, T, Li, S.S.C.
Deposit date:2018-07-30
Release date:2018-11-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Identification and characterization of a large family of superbinding bacterial SH2 domains.
Nat Commun, 9, 2018
5MTN
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BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
Descriptor: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTJ
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BU of 5mtj by Molmil
Yes1-SH2 in complex with monobody Mb(Yes_1)
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
Authors:Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-09
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
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BU of 5mtm by Molmil
Monobody Mb(Lck_3) bound to Lck-SH2 domain
Descriptor: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
7WFY
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BU of 7wfy by Molmil
Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide
Descriptor: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2
Authors:Zhang, Y.J, Liu, Y.R, Wu, B.
Deposit date:2021-12-27
Release date:2022-12-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.449 Å)
Cite:Vav2 is a novel APP-interacting protein that regulates APP protein level.
Sci Rep, 12, 2022
2YSX
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BU of 2ysx by Molmil
Solution structure of the human SHIP SH2 domain
Descriptor: Signaling inositol polyphosphate phosphatase SHIP II
Authors:Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-04
Release date:2008-04-08
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the human SHIP SH2 domain
To be Published
5JN0
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BU of 5jn0 by Molmil
CRK-II SH2 domain
Descriptor: CHLORIDE ION, CRK-II SH2 domain
Authors:Cho, J.-H.
Deposit date:2016-04-29
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.677 Å)
Cite:CRK-II SH2 domain
To Be Published
2YU7
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BU of 2yu7 by Molmil
Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Descriptor: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A
Authors:Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-05
Release date:2008-04-15
Last modified:2024-11-13
Method:SOLUTION NMR
Cite:Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
To be Published
5KAZ
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BU of 5kaz by Molmil
Human SH2D1B structure
Descriptor: SH2 domain-containing protein 1B, SULFATE ION
Authors:Taha, M, Nezerwa, E, Nam, H.-J.
Deposit date:2016-06-02
Release date:2017-04-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
3C7I
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BU of 3c7i by Molmil
X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.
Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide
Authors:Benfield, A.P, Martin, S.F.
Deposit date:2008-02-07
Release date:2008-08-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 118, 2006
4P9Z
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BU of 4p9z by Molmil
Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Clements, J.H, Martin, S.F.
Deposit date:2014-04-06
Release date:2014-06-18
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction.
Bioorg.Med.Chem.Lett., 24, 2014
5X94
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BU of 5x94 by Molmil
Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex
Descriptor: Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11
Authors:Senda, M, Senda, T.
Deposit date:2017-03-05
Release date:2017-09-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Cell Rep, 20, 2017
7MP3
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BU of 7mp3 by Molmil
Grb7-SH2 domain in complex with bicyclic peptide B8
Descriptor: Growth factor receptor-bound protein 7, bicyclic peptide B8
Authors:Colson, R, Wilce, M.C.J, Wilce, J.A.
Deposit date:2021-05-04
Release date:2022-02-02
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability.
Biomedicines, 10, 2022
4QSY
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BU of 4qsy by Molmil
SHP2 SH2 domain in complex with GAB1 peptide
Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11
Authors:Gogl, G, Remenyi, A.
Deposit date:2014-07-06
Release date:2015-07-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling
To be Published
6ICH
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BU of 6ich by Molmil
Grb2 SH2 domain in domain swapped dimer form
Descriptor: Growth factor receptor-bound protein 2
Authors:Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2018-09-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Biophys Physicobio., 16, 2019
5W3R
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BU of 5w3r by Molmil
SH2B1 SH2 Domain
Descriptor: PHENOL, PHOSPHATE ION, SH2B adapter protein 1
Authors:McKercher, M.A, Wuttke, D.S.
Deposit date:2017-06-08
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.386 Å)
Cite:Diversity in peptide recognition by the SH2 domain of SH2B1.
Proteins, 86, 2018
6ICG
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BU of 6icg by Molmil
Grb2 SH2 domain in phosphopeptide free form
Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION
Authors:Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2018-09-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Biophys Physicobio., 16, 2019
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
Descriptor: Tyrosine-protein kinase BTK, rF10 repebody
Authors:Duarte, D.P, Pojer, F, Hantschel, O.
Deposit date:2018-10-04
Release date:2020-05-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
4P9V
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BU of 4p9v by Molmil
Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2
Authors:Clements, J.H, Martin, S.F.
Deposit date:2014-04-06
Release date:2014-06-18
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction.
Bioorg.Med.Chem.Lett., 24, 2014
7MPH
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BU of 7mph by Molmil
GRB2 SH2 Domain with Compound 7
Descriptor: (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ...
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-05-04
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain.
Bioorg.Med.Chem.Lett., 51, 2021

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